(data stored in ACNUC9543 zone)

SWISSPROT: K7NTP5_PLAF7

ID   K7NTP5_PLAF7            Unreviewed;       679 AA.
AC   K7NTP5;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   08-MAY-2019, entry version 24.
DE   SubName: Full=Heat shock protein 70 {ECO:0000313|EMBL:CZT62759.1};
DE   SubName: Full=Hsp70-x {ECO:0000313|EMBL:AEX60710.1};
GN   ORFNames=PF3D7_0831700 {ECO:0000313|EMBL:CZT62759.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:AEX60710.1};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0000313|EMBL:CZT62759.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=3D7 {ECO:0000313|EMBL:CZT62759.1};
RA   Mao Y., Xie Y., Dai J.;
RL   Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:CZT62759.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=3D7 {ECO:0000313|EMBL:CZT62759.1};
RA   Keerthi T., Ganesan G., Rao M.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:AEX60710.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=3D7 {ECO:0000313|EMBL:AEX60710.1};
RA   Konishi E., Yamanaka A.;
RT   "Chikungunya in Indonesia.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:AEX60710.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=3D7 {ECO:0000313|EMBL:AEX60710.1};
RX   PubMed=22925632; DOI=10.1111/j.1462-5822.2012.01840.x;
RA   Kulzer S., Charnaud S., Dagan T., Riedel J., Mandal P., Pesce E.R.,
RA   Blatch G.L., Crabb B.S., Gilson P.R., Przyborski J.M.;
RT   "Plasmodium falciparum-encoded exported hsp70/hsp40 chaperone/co-
RT   chaperone complexes within the host erythrocyte.";
RL   Cell. Microbiol. 14:1784-1795(2012).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000256|RuleBase:RU003322}.
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DR   EMBL; JN900252; AEX60710.1; -; mRNA.
DR   EMBL; AL844507; CZT62759.1; -; Genomic_DNA.
DR   SMR; K7NTP5; -.
DR   EnsemblProtists; CZT62759; CZT62759; PF3D7_0831700.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0016887; F:ATPase activity; IBA:GO_Central.
DR   GO; GO:0042623; F:ATPase activity, coupled; IBA:GO_Central.
DR   GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR   GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0034605; P:cellular response to heat; IBA:GO_Central.
DR   GO; GO:0034620; P:cellular response to unfolded protein; IBA:GO_Central.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   GO; GO:0006986; P:response to unfolded protein; IBA:GO_Central.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   PRINTS; PR00301; HEATSHOCK70.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; K7NTP5.
DR   SWISS-2DPAGE; K7NTP5.
KW   ATP-binding {ECO:0000256|RuleBase:RU003322};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU003322};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Stress response {ECO:0000313|EMBL:CZT62759.1}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    679       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5011944390.
FT   COILED      546    570       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   679 AA;  75053 MW;  52746B3F9FFEDBA4 CRC64;
     MKTKICSYIH YIVLFLIATT TVHTASNNAE ESEVAIGIDL GTTYSCVGIC RNGVVDIIAN
     DQGNRTTPSY VAFTDTERLI GDAAKNQASR NPENTVFDAK RLIGRKFSET TVQSDMKHWP
     FTVKGGSDGK PMIEVSYQGE KKTFHPEEIS SMVLKKMKEV AETYLGKPVK NAVITVPAYF
     NDSQRQATKD AGAIAGLNVL RIINEPTAAA IAYGLDKKGK GEQNILIFDL GGGTFDVSLL
     TLEDGIFEVK ATSGDTHLGG EDFDNKLVNF CVQDFKKKNG GKDVSKNSKS LRRLRTQCEK
     AKRVLSSSAQ ATIEVDSLFD GIDYNVNITR AKFEELCMDQ FRNTLIPVEK VLKDAKMDKS
     QVHEIVLVGG STRIPKIQQL IKDFFNGKEP CKAINPDEAV AYGAAVQAAI LSGDQSSAVK
     DLLLLDVCPL SLGLETAGGV MTKLIERNTT IPTKKNQIFT TYADNQPGVL IQVYEGERAM
     TKDNNLLGKF QLEGIPPAPR SVPQIEVTFD IDANGILNVT ALDKGTGKQN QITITNDKGR
     LSKDDIDRMV NDAEKYKEED EQNKNRIEAR NNLENYCYNV KNTLQDENLK TKIPKDDSEK
     CMKTVKSVLD WLEKNQTAET EEYNEKEKDI SSVYNPIMTK IYQGASAQEP QKAEATNLRG
     RNSENKEAQN NGPTVEEVN
//

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