(data stored in ACNUC9543 zone)

SWISSPROT: A0A143ZZY8_PLAF7

ID   A0A143ZZY8_PLAF7        Unreviewed;      2269 AA.
AC   A0A143ZZY8;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   11-DEC-2019, entry version 21.
DE   SubName: Full=Erythrocyte membrane protein 1, PfEMP1 {ECO:0000313|EMBL:CZT62778.1};
GN   ORFNames=PF3D7_0833500 {ECO:0000313|EMBL:CZT62778.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT62778.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CZT62778.1; -; Genomic_DNA.
DR   RefSeq; XP_002808728.1; XM_002808682.1.
DR   EnsemblProtists; CZT62778; CZT62778; PF3D7_0833500.
DR   GeneID; 9221932; -.
DR   KEGG; pfa:PF3D7_0833500; -.
DR   KO; K13850; -.
DR   OMA; KEAHIFK; -.
DR   PhylomeDB; A0A143ZZY8; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR   GO; GO:0009405; P:pathogenesis; IEA:InterPro.
DR   Gene3D; 1.20.1310.20; -; 2.
DR   InterPro; IPR041480; CIDR1_gamma.
DR   InterPro; IPR004258; DBL.
DR   InterPro; IPR042202; Duffy-ag-bd_sf.
DR   InterPro; IPR008602; Duffy-antigen-binding.
DR   InterPro; IPR029211; PfEMP1_ATS.
DR   InterPro; IPR029210; PfEMP1_NTS.
DR   Pfam; PF15445; ATS; 1.
DR   Pfam; PF18562; CIDR1_gamma; 1.
DR   Pfam; PF05424; Duffy_binding; 2.
DR   Pfam; PF15447; NTS; 1.
DR   Pfam; PF03011; PFEMP; 2.
PE   4: Predicted;
DR   PRODOM; A0A143ZZY8.
DR   SWISS-2DPAGE; A0A143ZZY8.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          17..53
FT                   /note="NTS"
FT                   /evidence="ECO:0000259|Pfam:PF15447"
FT   DOMAIN          663..824
FT                   /note="PFEMP"
FT                   /evidence="ECO:0000259|Pfam:PF03011"
FT   DOMAIN          1464..1512
FT                   /note="CIDR1_gamma"
FT                   /evidence="ECO:0000259|Pfam:PF18562"
FT   DOMAIN          1532..1677
FT                   /note="PFEMP"
FT                   /evidence="ECO:0000259|Pfam:PF03011"
FT   DOMAIN          1797..2269
FT                   /note="ATS"
FT                   /evidence="ECO:0000259|Pfam:PF15445"
FT   REGION          470..496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          824..891
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          928..976
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          993..1029
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1082..1109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1164..1186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1212..1268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1672..1785
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1914..1965
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          203..230
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          381..405
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        475..496
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        824..844
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        847..866
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        999..1018
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1235..1268
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1672..1690
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1717..1741
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1742..1762
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2269 AA;  255775 MW;  1A5BA86A5DCA7EA3 CRC64;
     MAQGGRGGQV GGDDYSDAKH LLDSIGKKVH DEIVKKDAKT YIGELAGLLS QASIFGGETV
     AFSEPCGLIK NESQKLAALG DPCGSASEKR FSKERVDEYD KKKIKCSNSE GACAPYRRLH
     VCDKNMVKMD TNNDSKAKHD LLLDVCLAAK YEGESLKTYR AQYDEQYPSS VSTFTMCTML
     ARSFADIGDI VRGRDLYRGN RKKNETKTER EKLDDKLKEI FENIRKENNS KLKSLTDDQI
     REYWWTANRN DVWKAITCSA DKGNTYFRAT CIDLNESPSM ARDKCRCKDK SFTKETDQVP
     TYFDYVPQFL RWFEEWAEDF CRKKKKYVDI VKTYCRNETK GKYCSLNGYD CTKTKPAIGR
     LRMGNQCTKC FFACYPYEKW IDKKKEEFLK QKQKYEKEME KYTNEASGST GGRAKRSVST
     TNYDGYESKF YKILKDKYKD EGLNKFLEKL SNEDVCTKVD DEGGKIRFEK VNSGGTARSG
     GTSGTSSTSG DSGTNDINNK TFYRSKYCQP CPLCGMKRTK NGGNKWEEKS GGNCKSGKLY
     RPKGGKDVTP IRILKSGENH DDIEEKLNAF CQAQNGTGGV ANGSGSGTSD SQKLYQEWKC
     YQLEELTKVV QDGVEDEDDE DDEVYDKEVE GAGGLCILKK KKEKSEGKSQ NDPDEIQKTF
     HNFFYYWVAH MLKDSIHWRT KKLDKCLQNG KKKCGKKICN GDCDCFKRWV EQKRKEWDPI
     KKQFSKQKGI PFGCYFTTLE GVLQLEFLNE NTDEDAENNV SAEEAKEIQH LRQMLKQAGV
     AIGLDALGGC GTGGDSDNEK ETLMDKFLEE EEQFAEKCIK KCQETQKQPT GDGVADTSPD
     PSRDTNVDPE QEEEEEEDDS EEQDATVNGP EDGGGEATQQ PQGPSEKKEE VKVCETVKTA
     LGGNLDEACN QKYGLPQRHW GWKCIPSGSG STATREGEGS SDGGAKDGVG VNGGVLQRAR
     RGTPGEKTAT SSDSGAICVP PRRRRLYVTP LTRLAGGDKD TQASVSPQVV GETPQVSTPA
     LTSPPPSDPR ADVDLVKAFV ESAAVETFFL WDRYKKEWEH RNKKPQDGLL LFGESTASDH
     MAALSHTGGP QQQPGSVSDD PQSKLQKSGE IPTDFLRQMF YTLGDYRDIC IGGDRDIVGD
     TIVSNTEGGT PTKISEKIEQ ILSKQSGTHP PTPPGPPQTS VEKTTRESWW NAHAPSIWKG
     MICALTYKDG EEGKSPQVDT TVQKELLDKD GKPLNPQYQY TNAKLEEKNS GAKQNRNPTA
     PSDNKPTTLV DFISRPPYFR YLEEWGENFC KERKKRLKQI KVECKVDQDN DKNGKKCSGY
     GEDCHDNVFN NNYTTFPDFY CPDCGKYCSS YRKWIERKGK EFIKQKNAYK EQKTNFQTQS
     ETAKEFLQKL GSCKNNNRNE NAEDNNKIFE DNGDTFEPAK DCKPCSQFRV KSEKCNCRSS
     GKGNTCNDKN SIDVNDIGDG GNSTVLEMRV SDDSKSGSGF DGLGECKEAH IFKGIRKDVW
     TCEKVCGYNV CKPIKVDGKE NGENQIIIIR ALFKRWLEYF LEDYNKIRKK LKPCKKNGEG
     SPCIKDCDKI CECVTKWIEK KRTEWTNIKK HYLEKKHEKG DDGMTSLVKN FLEDLQDRPE
     FQNAIKPCND LNAFEKSCGL HGAEISQKKE GEDYDLVLCL LKKLEEKAKK CKEDHSSGEQ
     TEKECQEYPP LPDEEYENED ENEKTNIQPK FCPKQQTPPK QEDEDGCVPA EAPKEVVPEK
     KVPSDPPPAP APAAPPSTPA APKHPRGGEE KKAKPSLPNP PTVFDNPHVK TALVTSTLAW
     SVGIGFAAFT YFYLKKKTKS PVDLLRVLDI HKGDYDIPTK LSPNRYIPYT SGKYRGKTYI
     YLEGDSGTDS GYTDHYSDIT SSSESEYEEL DINDIYVPGS PKYKTLIEVV LEPSGNNTTA
     SGKNTTASGK TQSGNNTTAS GKNTPSDTQN DIQNDGIPSN KFSDNEWNTL KDDFISNMLQ
     NEPNTEQNML GYNVDNNTHP TMSRDNMEEK PFITSIHDRD LYTGEEYNYN VNMSTNNVDI
     PMSDKNGNYT GIDLINDTLS GNHNVDIYDE LLKRKENELF GTNNPKRTST YSVAKNTNSD
     PILNQINLFH TWLDRHRDMC EQWDTNNKKE ELLDKLKEEW ENETHSGNTH PSDSNKTLNT
     DVSIQIHMDD PKTTNEFTYV DSNPNQVDDT YVDTYPNNSS MDTILEDLEK YKEPYYDVQD
     DIYYDVNDDH DTSTVDSNNM DVPSKVQIEM DVNTKLVKEK YPIADVWDI
//

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