(data stored in SCRATCH zone)

SWISSPROT: D1CDC6_THET1

ID   D1CDC6_THET1            Unreviewed;       159 AA.
AC   D1CDC6;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   16-JAN-2019, entry version 67.
DE   RecName: Full=Transcription elongation factor GreA {ECO:0000256|HAMAP-Rule:MF_00105, ECO:0000256|RuleBase:RU000556};
DE   AltName: Full=Transcript cleavage factor GreA {ECO:0000256|HAMAP-Rule:MF_00105};
GN   Name=greA {ECO:0000256|HAMAP-Rule:MF_00105};
GN   OrderedLocusNames=Tter_0008 {ECO:0000313|EMBL:ACZ40932.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ40932.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ40932.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC       elongation past template-encoded arresting sites. The arresting
CC       sites in DNA have the property of trapping a certain fraction of
CC       elongating RNA polymerases that pass through, resulting in locked
CC       ternary complexes. Cleavage of the nascent transcript by cleavage
CC       factors such as GreA or GreB allows the resumption of elongation
CC       from the new 3'terminus. GreA releases sequences of 2 to 3
CC       nucleotides. {ECO:0000256|HAMAP-Rule:MF_00105,
CC       ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS01033799}.
CC   -!- SIMILARITY: Belongs to the GreA/GreB family. {ECO:0000256|HAMAP-
CC       Rule:MF_00105, ECO:0000256|RuleBase:RU000556,
CC       ECO:0000256|SAAS:SAAS01033218}.
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DR   EMBL; CP001825; ACZ40932.1; -; Genomic_DNA.
DR   RefSeq; WP_012873967.1; NC_013525.1.
DR   STRING; 525904.Tter_0008; -.
DR   EnsemblBacteria; ACZ40932; ACZ40932; Tter_0008.
DR   KEGG; ttr:Tter_0008; -.
DR   eggNOG; ENOG4108UKH; Bacteria.
DR   eggNOG; COG0782; LUCA.
DR   HOGENOM; HOG000241145; -.
DR   KO; K03624; -.
DR   OMA; TWLTQEA; -.
DR   OrthoDB; 1536415at2; -.
DR   BioCyc; TTER525904:G1GGS-8-MONOMER; -.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.180; -; 1.
DR   Gene3D; 3.10.50.30; -; 1.
DR   HAMAP; MF_00105; GreA_GreB; 1.
DR   InterPro; IPR036953; GreA/GreB_C_sf.
DR   InterPro; IPR006359; Tscrpt_elong_fac_GreA.
DR   InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR   InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR   InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR   InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR   InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR   PANTHER; PTHR30437; PTHR30437; 1.
DR   Pfam; PF01272; GreA_GreB; 1.
DR   Pfam; PF03449; GreA_GreB_N; 1.
DR   PIRSF; PIRSF006092; GreA_GreB; 1.
DR   SUPFAM; SSF46557; SSF46557; 1.
DR   TIGRFAMs; TIGR01462; greA; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1CDC6.
DR   SWISS-2DPAGE; D1CDC6.
KW   Coiled coil {ECO:0000256|HAMAP-Rule:MF_00105};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00105,
KW   ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS01033224};
KW   Elongation factor {ECO:0000313|EMBL:ACZ40932.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:ACZ40932.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00105,
KW   ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS01033216};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00105,
KW   ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS01033223}.
FT   DOMAIN        8     77       GreA_GreB_N. {ECO:0000259|Pfam:PF03449}.
FT   DOMAIN       84    159       GreA_GreB. {ECO:0000259|Pfam:PF01272}.
FT   COILED        4     34       {ECO:0000256|HAMAP-Rule:MF_00105}.
FT   COILED       51     78       {ECO:0000256|HAMAP-Rule:MF_00105}.
SQ   SEQUENCE   159 AA;  17316 MW;  E2633E83A0B16B4C CRC64;
     MSTNERVRLT EQGLKELREE LERLRTVERA KISARIREAK EGGDISESGE YEDAKHSQAF
     LEGRIKELEK LLANAEVIDR SAQPAGTVGL GSKVTVEENG RTYTYTIVDG AEAGRGRDGE
     VRISSKSAVG SALLGRRVGD SVEVEVPAGK LTFKILSVE
//

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