(data stored in SCRATCH zone)

SWISSPROT: D1CDK2_THET1

ID   D1CDK2_THET1            Unreviewed;       192 AA.
AC   D1CDK2;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   16-JAN-2019, entry version 60.
DE   RecName: Full=Holliday junction ATP-dependent DNA helicase RuvA {ECO:0000256|HAMAP-Rule:MF_00031, ECO:0000256|SAAS:SAAS01087591};
DE            EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_00031, ECO:0000256|SAAS:SAAS01087580};
GN   Name=ruvA {ECO:0000256|HAMAP-Rule:MF_00031};
GN   OrderedLocusNames=Tter_0086 {ECO:0000313|EMBL:ACZ41008.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41008.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41008.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- FUNCTION: The RuvA-RuvB complex in the presence of ATP renatures
CC       cruciform structure in supercoiled DNA with palindromic sequence,
CC       indicating that it may promote strand exchange reactions in
CC       homologous recombination. RuvAB is a helicase that mediates the
CC       Holliday junction migration by localized denaturation and
CC       reannealing. RuvA stimulates, in the presence of DNA, the weak
CC       ATPase activity of RuvB. {ECO:0000256|HAMAP-Rule:MF_00031,
CC       ECO:0000256|SAAS:SAAS01087604}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00031,
CC         ECO:0000256|SAAS:SAAS01122358};
CC   -!- SUBUNIT: Forms a complex with RuvB. {ECO:0000256|HAMAP-
CC       Rule:MF_00031, ECO:0000256|SAAS:SAAS00698583}.
CC   -!- SIMILARITY: Belongs to the RuvA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00031, ECO:0000256|SAAS:SAAS01087593}.
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DR   EMBL; CP001825; ACZ41008.1; -; Genomic_DNA.
DR   RefSeq; WP_012874043.1; NC_013525.1.
DR   STRING; 525904.Tter_0086; -.
DR   EnsemblBacteria; ACZ41008; ACZ41008; Tter_0086.
DR   KEGG; ttr:Tter_0086; -.
DR   eggNOG; ENOG4105KA4; Bacteria.
DR   eggNOG; COG0632; LUCA.
DR   HOGENOM; HOG000057116; -.
DR   KO; K03550; -.
DR   OMA; DCHGVGY; -.
DR   OrthoDB; 1370858at2; -.
DR   BioCyc; TTER525904:G1GGS-86-MONOMER; -.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0009379; C:Holliday junction helicase complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009378; F:four-way junction helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   CDD; cd14332; UBA_RuvA_C; 1.
DR   HAMAP; MF_00031; DNA_helic_RuvA; 1.
DR   InterPro; IPR013849; DNA_helicase_Holl-junc_RuvA_I.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR000085; RuvA.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR011114; RuvA_C.
DR   InterPro; IPR036267; RuvA_C_sf.
DR   PANTHER; PTHR33796; PTHR33796; 1.
DR   Pfam; PF07499; RuvA_C; 1.
DR   Pfam; PF01330; RuvA_N; 1.
DR   SUPFAM; SSF46929; SSF46929; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00084; ruvA; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1CDK2.
DR   SWISS-2DPAGE; D1CDK2.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00031,
KW   ECO:0000256|SAAS:SAAS01087601};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_00031,
KW   ECO:0000256|SAAS:SAAS00881019};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_00031,
KW   ECO:0000256|SAAS:SAAS01087577};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_00031,
KW   ECO:0000256|SAAS:SAAS00881020};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00031,
KW   ECO:0000256|SAAS:SAAS01087589};
KW   Helicase {ECO:0000256|HAMAP-Rule:MF_00031,
KW   ECO:0000256|SAAS:SAAS01087596, ECO:0000313|EMBL:ACZ41008.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00031,
KW   ECO:0000256|SAAS:SAAS01087608};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00031,
KW   ECO:0000256|SAAS:SAAS01087598};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW   SOS response {ECO:0000256|HAMAP-Rule:MF_00031,
KW   ECO:0000256|SAAS:SAAS00880989}.
FT   DOMAIN        1     62       RuvA_N. {ECO:0000259|Pfam:PF01330}.
FT   DOMAIN      147    188       RuvA_C. {ECO:0000259|Pfam:PF07499}.
SQ   SEQUENCE   192 AA;  21011 MW;  3DFBA8E9147AB246 CRC64;
     MIASIKGHIE YKLNDGLIVQ VGGVGLRVFT PSSMVREIGE IGDEVYLHTH LMVREDALTL
     YGFSTREQLR LFELLISVTG VGPNHALNIL SSASVEEIQT AIAQENAQFF SLIPRIGKKL
     AARIILELKG KVEPSGEAVQ IISHKDEELV SALLALGYTL GEAQAAVRSL PTDKELPMEE
     KLRLALSYFS TP
//

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