(data stored in SCRATCH zone)

SWISSPROT: D1CDP9_THET1

ID   D1CDP9_THET1            Unreviewed;       455 AA.
AC   D1CDP9;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   16-JAN-2019, entry version 65.
DE   RecName: Full=Probable glycine dehydrogenase (decarboxylating) subunit 1 {ECO:0000256|HAMAP-Rule:MF_00712, ECO:0000256|SAAS:SAAS01034009};
DE            EC=1.4.4.2 {ECO:0000256|HAMAP-Rule:MF_00712, ECO:0000256|SAAS:SAAS01082692};
DE   AltName: Full=Glycine cleavage system P-protein subunit 1 {ECO:0000256|HAMAP-Rule:MF_00712};
DE   AltName: Full=Glycine decarboxylase subunit 1 {ECO:0000256|HAMAP-Rule:MF_00712};
DE   AltName: Full=Glycine dehydrogenase (aminomethyl-transferring) subunit 1 {ECO:0000256|HAMAP-Rule:MF_00712};
GN   Name=gcvPA {ECO:0000256|HAMAP-Rule:MF_00712};
GN   OrderedLocusNames=Tter_0133 {ECO:0000313|EMBL:ACZ41055.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41055.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41055.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC       glycine. The P protein binds the alpha-amino group of glycine
CC       through its pyridoxal phosphate cofactor; CO(2) is released and
CC       the remaining methylamine moiety is then transferred to the
CC       lipoamide cofactor of the H protein. {ECO:0000256|HAMAP-
CC       Rule:MF_00712, ECO:0000256|SAAS:SAAS01034013}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycine + H(+) + N(6)-lipoyl-L-lysyl-[glycine-cleavage
CC         complex H protein] = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-
CC         lysyl-[glycine-cleavage complex H protein] + CO2;
CC         Xref=Rhea:RHEA:24304, Rhea:RHEA-COMP:10494, Rhea:RHEA-
CC         COMP:10495, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57305, ChEBI:CHEBI:83099, ChEBI:CHEBI:83143;
CC         EC=1.4.4.2; Evidence={ECO:0000256|HAMAP-Rule:MF_00712,
CC         ECO:0000256|SAAS:SAAS01118902};
CC   -!- SUBUNIT: The glycine cleavage system is composed of four proteins:
CC       P, T, L and H. In this organism, the P 'protein' is a heterodimer
CC       of two subunits. {ECO:0000256|HAMAP-Rule:MF_00712,
CC       ECO:0000256|SAAS:SAAS00731725}.
CC   -!- SIMILARITY: Belongs to the GcvP family. N-terminal subunit
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_00712,
CC       ECO:0000256|SAAS:SAAS01034010}.
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DR   EMBL; CP001825; ACZ41055.1; -; Genomic_DNA.
DR   RefSeq; WP_012874090.1; NC_013525.1.
DR   STRING; 525904.Tter_0133; -.
DR   EnsemblBacteria; ACZ41055; ACZ41055; Tter_0133.
DR   KEGG; ttr:Tter_0133; -.
DR   eggNOG; ENOG4107QK8; Bacteria.
DR   eggNOG; COG0403; LUCA.
DR   HOGENOM; HOG000132025; -.
DR   KO; K00282; -.
DR   OMA; MYDGASA; -.
DR   OrthoDB; 870147at2; -.
DR   BioCyc; TTER525904:G1GGS-135-MONOMER; -.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:UniProtKB-UniRule.
DR   GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR   CDD; cd00613; GDC-P; 1.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   HAMAP; MF_00712; GcvPA; 1.
DR   InterPro; IPR023010; GcvPA.
DR   InterPro; IPR020581; GDC_P.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_dom1.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   PANTHER; PTHR42806; PTHR42806; 1.
DR   Pfam; PF02347; GDC-P; 1.
DR   PIRSF; PIRSF006815; GcvPA; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1CDP9.
DR   SWISS-2DPAGE; D1CDP9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00712,
KW   ECO:0000256|SAAS:SAAS01082684, ECO:0000313|EMBL:ACZ41055.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323}.
SQ   SEQUENCE   455 AA;  49636 MW;  B3789EC97E2EFF59 CRC64;
     MPYIPHTDKE RQEMLSRIGV NSIDELLTAI PERYKYPQLR IGPGLSEAEV AKKVNALSER
     NLDVDHVACF AGGGAYNHFI PAAVKSVTSR NEFYTSYTPY QAEVSQGTLQ SIYEFQTMIA
     ALMGMDVANA SMYDGATAAA EGALMAVHYT RRPKIVIVPT FHPEWVEVIR TFTSGVELEI
     VVAGELPDNF KSTPRDIATY VDERTACVLV QYPNFFGSIE DIKGYADLAH SVGALLVVAA
     YPIALGLLKP PGELGADIAV GEGQSLGNEL NFGGPYLGLF ATRKDFIRYM PGRLVGATKD
     VDGKRGYVLT LQTREQHIRR EKATSNICTN EALNALASTV YLSLMGKQGL AKVAQLCVNN
     AHYLAGVLSA VPGWEVVSAE PFFNEFVLKC PVPASQVVSA LIDEGILAGI DLGRFDSKLS
     EYLLVCATEM NTKEEMDRYA SLISNVKAVK ELERV
//

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