(data stored in SCRATCH zone)

SWISSPROT: D1CE25_THET1

ID   D1CE25_THET1            Unreviewed;       374 AA.
AC   D1CE25;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   08-MAY-2019, entry version 50.
DE   RecName: Full=Zinc metalloprotease {ECO:0000256|PIRNR:PIRNR006404};
GN   OrderedLocusNames=Tter_0259 {ECO:0000313|EMBL:ACZ41181.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41181.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41181.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRNR:PIRNR006404,
CC         ECO:0000256|PIRSR:PIRSR006404-2};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRNR:PIRNR006404,
CC       ECO:0000256|PIRSR:PIRSR006404-2};
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|PIRNR:PIRNR006404}; Multi-pass membrane protein
CC       {ECO:0000256|PIRNR:PIRNR006404}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family.
CC       {ECO:0000256|PIRNR:PIRNR006404}.
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DR   EMBL; CP001825; ACZ41181.1; -; Genomic_DNA.
DR   STRING; 525904.Tter_0259; -.
DR   MEROPS; M50.006; -.
DR   EnsemblBacteria; ACZ41181; ACZ41181; Tter_0259.
DR   KEGG; ttr:Tter_0259; -.
DR   eggNOG; ENOG4106KZE; Bacteria.
DR   eggNOG; COG1994; LUCA.
DR   HOGENOM; HOG000224506; -.
DR   OMA; FYVNPSW; -.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR008915; Peptidase_M50.
DR   InterPro; IPR016483; UCP006404_Pept_M50_CBS.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   PIRSF; PIRSF006404; UCP006404_Pept_M50_CBS; 1.
DR   SMART; SM00116; CBS; 2.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
DR   PRODOM; D1CE25.
DR   SWISS-2DPAGE; D1CE25.
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Cell membrane {ECO:0000256|PIRNR:PIRNR006404};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR006404};
KW   Membrane {ECO:0000256|PIRNR:PIRNR006404};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR006404,
KW   ECO:0000256|PIRSR:PIRSR006404-2};
KW   Metalloprotease {ECO:0000256|PIRNR:PIRNR006404};
KW   Protease {ECO:0000256|PIRNR:PIRNR006404};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW   Transmembrane {ECO:0000256|PIRNR:PIRNR006404};
KW   Transmembrane helix {ECO:0000256|PIRNR:PIRNR006404};
KW   Zinc {ECO:0000256|PIRNR:PIRNR006404, ECO:0000256|PIRSR:PIRSR006404-2}.
FT   TRANSMEM     12     36       Helical. {ECO:0000256|PIRNR:PIRNR006404}.
FT   TRANSMEM     51     70       Helical. {ECO:0000256|PIRNR:PIRNR006404}.
FT   TRANSMEM    111    129       Helical. {ECO:0000256|PIRNR:PIRNR006404}.
FT   TRANSMEM    141    162       Helical. {ECO:0000256|PIRNR:PIRNR006404}.
FT   TRANSMEM    190    212       Helical. {ECO:0000256|PIRNR:PIRNR006404}.
FT   TRANSMEM    218    236       Helical. {ECO:0000256|PIRNR:PIRNR006404}.
FT   DOMAIN      251    312       CBS. {ECO:0000259|PROSITE:PS51371}.
FT   DOMAIN      316    373       CBS. {ECO:0000259|PROSITE:PS51371}.
FT   ACT_SITE     72     72       {ECO:0000256|PIRSR:PIRSR006404-1}.
FT   METAL        71     71       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR006404-2}.
FT   METAL        75     75       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR006404-2}.
FT   METAL       168    168       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR006404-2}.
SQ   SEQUENCE   374 AA;  41723 MW;  E271A06012376F97 CRC64;
     MSMNPLSGFR LCKIFGIPIY VNPTWFLVFA LIVYSLASDR LPEFIPGSSN LFYWLAAIVG
     TLLFFLSLTA HELGHSLVSK SFGIPVRSIT LHMFGGIAQL GSEVRRAREE FWIAIAGPIV
     SFALFLTFWG LSDIITSSMP AIGSFLSLLA LLNIGVALFN LFPGFPLDGG RILRSIVWGI
     SGNYIRATRI SALGGQLFGY LLIAAGVLFA ILDRYLGYLW MVLLGAFIII LARQSYRQSL
     TYHKLSNIKL ADVYIPLVHV EEDTLVSDLF TDYIRSSGRQ FFIVDFHGEP VGLLTPYEIL
     RLPQPFWHIT PVRSIMINLA SVGRLPADLS LFDAMNLFER TGHNLFLVID DDRIEGIVTR
     DTVVHVLGRT TSRV
//

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