(data stored in SCRATCH zone)

SWISSPROT: D1CE91_THET1

ID   D1CE91_THET1            Unreviewed;       376 AA.
AC   D1CE91;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   08-MAY-2019, entry version 66.
DE   RecName: Full=Dihydroorotate dehydrogenase (quinone) {ECO:0000256|SAAS:SAAS00767036};
DE            EC=1.3.5.2 {ECO:0000256|SAAS:SAAS00767036};
GN   OrderedLocusNames=Tter_0325 {ECO:0000313|EMBL:ACZ41247.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41247.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41247.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- FUNCTION: Catalyzes the conversion of dihydroorotate to orotate
CC       with quinone as electron acceptor.
CC       {ECO:0000256|SAAS:SAAS00767022}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-dihydroorotate + a quinone = a quinol + orotate;
CC         Xref=Rhea:RHEA:30187, ChEBI:CHEBI:24646, ChEBI:CHEBI:30839,
CC         ChEBI:CHEBI:30864, ChEBI:CHEBI:132124; EC=1.3.5.2;
CC         Evidence={ECO:0000256|SAAS:SAAS01124321};
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|SAAS:SAAS00611625};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; orotate from (S)-dihydroorotate (quinone route): step
CC       1/1. {ECO:0000256|SAAS:SAAS00767035}.
CC   -!- SIMILARITY: Belongs to the dihydroorotate dehydrogenase family.
CC       Type 2 subfamily. {ECO:0000256|SAAS:SAAS00767034}.
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DR   EMBL; CP001825; ACZ41247.1; -; Genomic_DNA.
DR   RefSeq; WP_012874282.1; NC_013525.1.
DR   STRING; 525904.Tter_0325; -.
DR   EnsemblBacteria; ACZ41247; ACZ41247; Tter_0325.
DR   KEGG; ttr:Tter_0325; -.
DR   eggNOG; ENOG41080KZ; Bacteria.
DR   eggNOG; COG0167; LUCA.
DR   HOGENOM; HOG000225103; -.
DR   KO; K00254; -.
DR   OMA; ALNRMGF; -.
DR   OrthoDB; 1109542at2; -.
DR   BioCyc; TTER525904:G1GGS-329-MONOMER; -.
DR   UniPathway; UPA00070; UER00946.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004152; F:dihydroorotate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04738; DHOD_2_like; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005720; Dihydroorotate_DH.
DR   InterPro; IPR005719; Dihydroorotate_DH_2.
DR   InterPro; IPR001295; Dihydroorotate_DH_CS.
DR   Pfam; PF01180; DHO_dh; 1.
DR   TIGRFAMs; TIGR01036; pyrD_sub2; 1.
DR   PROSITE; PS00911; DHODEHASE_1; 1.
DR   PROSITE; PS00912; DHODEHASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1CE91.
DR   SWISS-2DPAGE; D1CE91.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Flavoprotein {ECO:0000256|SAAS:SAAS00243575};
KW   FMN {ECO:0000256|SAAS:SAAS00459616};
KW   Membrane {ECO:0000256|SAAS:SAAS00767044};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00243616,
KW   ECO:0000313|EMBL:ACZ41247.1};
KW   Pyrimidine biosynthesis {ECO:0000256|SAAS:SAAS00767026};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323}.
FT   DOMAIN       58    350       DHO_dh. {ECO:0000259|Pfam:PF01180}.
SQ   SEQUENCE   376 AA;  40630 MW;  A69FE5EE73A9754F CRC64;
     MATGIYKHLV LPLLDRLDSE TWHERVRHGL HTVEQVPLGP EFLEILAWKG RRVVDPRLKV
     SLAGVQLENP LIVGAGWDKS GISIRALYAL GFASVEVGTV TPRPQPGNPR PRQFVLSSGV
     VINRLGFNNP GADAVAANLE SYKSDNIPVG ISIGKNKDDP EDRAPLAYAE VARKLYPYGS
     YFVINVSSPN TPGLRSLQRK EALLSIAQSV LDVMDSYGAR KPLFIKIAPE LSYQEVDEIL
     DVVLQLGLAG VVATNTVALG DVKARYGEGW RLQPGGLSGD DEVFRHMSTS KVAYIYSQTK
     GSIDIIGVGG VKDAHTALEK ILAGATAVQV VTAIRSEGLA VAARTNLGLL EWLDKNGVKS
     ISNVVGARYE DFLDTK
//

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