(data stored in SCRATCH zone)

SWISSPROT: D1CEH9_THET1

ID   D1CEH9_THET1            Unreviewed;       514 AA.
AC   D1CEH9;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   16-JAN-2019, entry version 64.
DE   RecName: Full=Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|HAMAP-Rule:MF_00966};
DE            Short=G6PD {ECO:0000256|HAMAP-Rule:MF_00966};
DE            EC=1.1.1.49 {ECO:0000256|HAMAP-Rule:MF_00966};
GN   Name=zwf {ECO:0000256|HAMAP-Rule:MF_00966};
GN   OrderedLocusNames=Tter_0413 {ECO:0000313|EMBL:ACZ41335.1};
OS   Thermobaculum terrenum (strain ATCC BAA-798 / YNP1).
OC   Bacteria; Thermobaculum.
OX   NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ41335.1, ECO:0000313|Proteomes:UP000000323};
RN   [1] {ECO:0000313|EMBL:ACZ41335.1, ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   PubMed=21304745;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Del Rio T.G., Nolan M.,
RA   Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Lu M., Brettin T.,
RA   Detter J.C., Goker M., Tindall B.J., Beck B., McDermott T.R.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Cheng J.F.;
RT   "Complete genome sequence of 'Thermobaculum terrenum' type strain
RT   (YNP1).";
RL   Stand. Genomic Sci. 3:153-162(2010).
RN   [2] {ECO:0000313|Proteomes:UP000000323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX   DOI=10.4056/sigs.1153107;
RA   Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T.,
RA   Nolan M., Tice H., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Lu M.,
RA   Brettin T., Detter J., Goker M., Tindall B., Beck B., McDermott T.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P.,
RA   Kyrpides N., Klenk H., Cheng J.;
RT   "Complete genome sequence of Thermobaculum terrenum type strain
RT   (YNP1T).";
RL   Stand. Genomic Sci. 3:153-162(2010).
CC   -!- FUNCTION: Catalyzes the oxidation of glucose 6-phosphate to 6-
CC       phosphogluconolactone. {ECO:0000256|HAMAP-Rule:MF_00966}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-
CC         1,5-lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57955,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:61548; EC=1.1.1.49;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00966};
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 1/3. {ECO:0000256|HAMAP-Rule:MF_00966}.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase
CC       family. {ECO:0000256|HAMAP-Rule:MF_00966}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_00966}.
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DR   EMBL; CP001825; ACZ41335.1; -; Genomic_DNA.
DR   RefSeq; WP_012874370.1; NC_013525.1.
DR   STRING; 525904.Tter_0413; -.
DR   EnsemblBacteria; ACZ41335; ACZ41335; Tter_0413.
DR   KEGG; ttr:Tter_0413; -.
DR   eggNOG; ENOG4105D8W; Bacteria.
DR   eggNOG; COG0364; LUCA.
DR   HOGENOM; HOG000046192; -.
DR   KO; K00036; -.
DR   OMA; VEICVYE; -.
DR   OrthoDB; 1153269at2; -.
DR   BioCyc; TTER525904:G1GGS-416-MONOMER; -.
DR   UniPathway; UPA00115; UER00408.
DR   Proteomes; UP000000323; Chromosome 1.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0050661; F:NADP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00966; G6PD; 1.
DR   InterPro; IPR001282; G6P_DH.
DR   InterPro; IPR019796; G6P_DH_AS.
DR   InterPro; IPR022675; G6P_DH_C.
DR   InterPro; IPR022674; G6P_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23429; PTHR23429; 1.
DR   Pfam; PF02781; G6PD_C; 1.
DR   Pfam; PF00479; G6PD_N; 1.
DR   PIRSF; PIRSF000110; G6PD; 1.
DR   PRINTS; PR00079; G6PDHDRGNASE.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00871; zwf; 1.
DR   PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1CEH9.
DR   SWISS-2DPAGE; D1CEH9.
KW   Carbohydrate metabolism {ECO:0000256|HAMAP-Rule:MF_00966};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000323};
KW   Glucose metabolism {ECO:0000256|HAMAP-Rule:MF_00966};
KW   NADP {ECO:0000256|HAMAP-Rule:MF_00966};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00966,
KW   ECO:0000313|EMBL:ACZ41335.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000323}.
FT   DOMAIN       25    211       G6PD_N. {ECO:0000259|Pfam:PF00479}.
FT   DOMAIN      213    512       G6PD_C. {ECO:0000259|Pfam:PF02781}.
FT   NP_BIND     104    105       NADP. {ECO:0000256|HAMAP-Rule:MF_00966}.
FT   ACT_SITE    264    264       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_00966}.
FT   BINDING      62     62       NADP. {ECO:0000256|HAMAP-Rule:MF_00966}.
FT   BINDING     172    172       NADP. {ECO:0000256|HAMAP-Rule:MF_00966}.
FT   BINDING     202    202       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00966}.
FT   BINDING     206    206       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00966, ECO:0000256|PROSITE-ProRule:
FT                                PRU10005}.
FT   BINDING     240    240       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00966}.
FT   BINDING     259    259       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00966}.
FT   BINDING     364    364       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00966}.
SQ   SEQUENCE   514 AA;  59018 MW;  1C6D887939319B65 CRC64;
     MTTVIENPLR ASTHIERTPQ PCAIVVFGAT GDLTHRKLVP ALYNLAVDKL LPPNFAIIGF
     ARRPWSDDYF REEMLKGVQE FSRRKPDPKI WESFAQNLYY VQSEFDNVEG YQKLKDFLDK
     LDSEKGLGGN RLYYLSASPS YYETIVERLG DVGLSGRSRR AEQGYTRIII EKPFGHDLQS
     ARELNDLLHQ FFSEDQIFRI DHYLGKETVQ NILVFRFANS IFEPIWNRNY IDHVQITAAE
     SIGIEGRGKY YEESGALRDM MQSHLLQLLN LVAMEPPVAF DANSVRDEKV KVLRAIRPIR
     GNAVADQVVR GQYGPGLIDG KEVPGYRQEP NVDPNSVTET YVAIKLFIDN WRWQGVPIYM
     RTGKRLKKRV TEIAIQFKQP PLLLFGQQTD GIIEPNVLAL RIQPDEGISL TVSVKTPGTR
     LNIRPVKMEF LYGTGFGIEP PEAYERLLLD AMIGDSTLFT RHDEVEASWA FITDILDAWK
     QLPPPQFPNY ESGSWGPRDA DRLLYRDGRE WRWL
//

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