(data stored in SCRATCH zone)

SWISSPROT: D1YUX0_METPS

ID   D1YUX0_METPS            Unreviewed;       280 AA.
AC   D1YUX0;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   11-DEC-2019, entry version 57.
DE   RecName: Full=Shikimate kinase {ECO:0000256|HAMAP-Rule:MF_00370};
DE            Short=SK {ECO:0000256|HAMAP-Rule:MF_00370};
DE            EC=2.7.1.71 {ECO:0000256|HAMAP-Rule:MF_00370};
GN   Name=aroK {ECO:0000256|HAMAP-Rule:MF_00370,
GN   ECO:0000313|EMBL:BAI60242.1};
GN   OrderedLocusNames=MCP_0170 {ECO:0000313|EMBL:BAI60242.1};
OS   Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS   SANAE).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI60242.1, ECO:0000313|Proteomes:UP000001882};
RN   [1] {ECO:0000313|Proteomes:UP000001882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC   {ECO:0000313|Proteomes:UP000001882};
RX   PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA   Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA   Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA   Mori K., Fujita N., Imachi H., Takai K.;
RT   "Genome sequence of a mesophilic hydrogenotrophic methanogen Methanocella
RT   paludicola, the first cultivated representative of the order
RT   Methanocellales.";
RL   PLoS ONE 6:E22898-E22898(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + shikimate = 3-phosphoshikimate + ADP + H(+);
CC         Xref=Rhea:RHEA:13121, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:36208, ChEBI:CHEBI:145989, ChEBI:CHEBI:456216;
CC         EC=2.7.1.71; Evidence={ECO:0000256|HAMAP-Rule:MF_00370};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       5/7. {ECO:0000256|HAMAP-Rule:MF_00370}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00370}.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Archaeal shikimate
CC       kinase subfamily. {ECO:0000256|HAMAP-Rule:MF_00370}.
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DR   EMBL; AP011532; BAI60242.1; -; Genomic_DNA.
DR   STRING; 304371.MCP_0170; -.
DR   EnsemblBacteria; BAI60242; BAI60242; MCP_0170.
DR   KEGG; mpd:MCP_0170; -.
DR   PATRIC; fig|304371.9.peg.176; -.
DR   eggNOG; arCOG01025; Archaea.
DR   eggNOG; COG1685; LUCA.
DR   HOGENOM; HOG000105526; -.
DR   KO; K00891; -.
DR   OMA; DATASYY; -.
DR   UniPathway; UPA00053; UER00088.
DR   Proteomes; UP000001882; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004765; F:shikimate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.230.10; -; 1.
DR   HAMAP; MF_00370; Shik_kinase_arch; 1.
DR   InterPro; IPR036554; GHMP_kinase_C_sf.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   InterPro; IPR010189; SK_arc.
DR   PANTHER; PTHR20861:SF3; PTHR20861:SF3; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF005758; Shikimt_kin_arch; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55060; SSF55060; 1.
DR   TIGRFAMs; TIGR01920; Shik_kin_archae; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1YUX0.
DR   SWISS-2DPAGE; D1YUX0.
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00370};
KW   Aromatic amino acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00370};
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00370};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00370};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00370, ECO:0000313|EMBL:BAI60242.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00370};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001882};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00370}.
FT   DOMAIN          73..142
FT                   /note="GHMP_kinases_N"
FT                   /evidence="ECO:0000259|Pfam:PF00288"
FT   NP_BIND         81..91
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00370"
SQ   SEQUENCE   280 AA;  29585 MW;  FB404A2C443C767A CRC64;
     MRGHGIAFGA GTVINAIATY KGSAFGITLK TEAEVTLRGD LVEGEIEGGG DTRLIERACE
     LVLEEFDVDS GAKIRTKSQV PQASGLKSSS AAANATVLAT LRAIGRDMEP LDMVRLGVRA
     ALDTGVSITG AFDDACASML GGIVVTDNRN NELLKREPVE SDVIIYAPDK KAFSSQTNVA
     RSRAIGPWVD AAFDMAMRGE YRRAMTLNGF LYTAALGYSP EPMMAALELG VDAVSLSGTG
     PSYVALASGE KLEELRAAWS SYPGKVMITR TNNTGAHTLR
//

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