(data stored in SCRATCH zone)

SWISSPROT: D1YVI8_METPS

ID   D1YVI8_METPS            Unreviewed;       114 AA.
AC   D1YVI8;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   11-DEC-2019, entry version 51.
DE   RecName: Full=Dihydroneopterin aldolase {ECO:0000256|HAMAP-Rule:MF_02130};
DE            Short=DHNA {ECO:0000256|HAMAP-Rule:MF_02130};
DE            EC=4.1.2.25 {ECO:0000256|HAMAP-Rule:MF_02130};
DE   AltName: Full=7,8-dihydroneopterin aldolase {ECO:0000256|HAMAP-Rule:MF_02130};
GN   Name=mptD {ECO:0000256|HAMAP-Rule:MF_02130};
GN   OrderedLocusNames=MCP_0388 {ECO:0000313|EMBL:BAI60460.1};
OS   Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS   SANAE).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI60460.1, ECO:0000313|Proteomes:UP000001882};
RN   [1] {ECO:0000313|Proteomes:UP000001882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC   {ECO:0000313|Proteomes:UP000001882};
RX   PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA   Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA   Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA   Mori K., Fujita N., Imachi H., Takai K.;
RT   "Genome sequence of a mesophilic hydrogenotrophic methanogen Methanocella
RT   paludicola, the first cultivated representative of the order
RT   Methanocellales.";
RL   PLoS ONE 6:E22898-E22898(2011).
CC   -!- FUNCTION: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to
CC       6-hydroxymethyl-7,8-dihydropterin (6-HMD). {ECO:0000256|HAMAP-
CC       Rule:MF_02130}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin +
CC         glycolaldehyde; Xref=Rhea:RHEA:10540, ChEBI:CHEBI:17001,
CC         ChEBI:CHEBI:17071, ChEBI:CHEBI:44841; EC=4.1.2.25;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_02130};
CC   -!- PATHWAY: Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin
CC       biosynthesis. {ECO:0000256|HAMAP-Rule:MF_02130}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_02130}.
CC   -!- SIMILARITY: Belongs to the archaeal dihydroneopterin aldolase family.
CC       {ECO:0000256|HAMAP-Rule:MF_02130}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP011532; BAI60460.1; -; Genomic_DNA.
DR   STRING; 304371.MCP_0388; -.
DR   EnsemblBacteria; BAI60460; BAI60460; MCP_0388.
DR   KEGG; mpd:MCP_0388; -.
DR   PATRIC; fig|304371.9.peg.398; -.
DR   eggNOG; arCOG04705; Archaea.
DR   eggNOG; COG2098; LUCA.
DR   HOGENOM; HOG000229383; -.
DR   KO; K09739; -.
DR   OMA; FHQFVGT; -.
DR   UniPathway; UPA00065; -.
DR   Proteomes; UP000001882; Chromosome.
DR   GO; GO:0004150; F:dihydroneopterin aldolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2001118; P:tetrahydromethanopterin biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1300.20; -; 1.
DR   HAMAP; MF_02130; DHNA_arch; 1.
DR   InterPro; IPR027508; DHN_aldolase_MptD.
DR   InterPro; IPR036839; MptD_sf.
DR   InterPro; IPR007181; MtpD_C.
DR   Pfam; PF04038; DHNA; 1.
DR   SUPFAM; SSF143560; SSF143560; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1YVI8.
DR   SWISS-2DPAGE; D1YVI8.
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_02130};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001882}.
FT   DOMAIN          4..108
FT                   /note="DHNA"
FT                   /evidence="ECO:0000259|Pfam:PF04038"
FT   BINDING         12
FT                   /note="Substrate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02130"
FT   BINDING         106
FT                   /note="Substrate; via amide nitrogen and carbonyl oxygen"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02130"
SQ   SEQUENCE   114 AA;  12607 MW;  D776443775F69042 CRC64;
     MSVTPRDKAV FEAGIKLGAL YHQFVGSPIS LKTVDSLEKA IAQSISVQPF VRSITVQIDR
     EMVKQNLSAF GYTELKGPML TVDAVIKYEN YEVSVGMALK DGYPLMHVKD VKEV
//

If you have problems or comments...

PBIL Back to PBIL home page