(data stored in SCRATCH zone)

SWISSPROT: D1YVJ5_METPS

ID   D1YVJ5_METPS            Unreviewed;       526 AA.
AC   D1YVJ5;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   11-DEC-2019, entry version 63.
DE   RecName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000256|RuleBase:RU363003};
DE            EC=1.1.1.95 {ECO:0000256|RuleBase:RU363003};
GN   Name=serA {ECO:0000313|EMBL:BAI60467.1};
GN   OrderedLocusNames=MCP_0395 {ECO:0000313|EMBL:BAI60467.1};
OS   Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS   SANAE).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI60467.1, ECO:0000313|Proteomes:UP000001882};
RN   [1] {ECO:0000313|Proteomes:UP000001882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC   {ECO:0000313|Proteomes:UP000001882};
RX   PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA   Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA   Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA   Mori K., Fujita N., Imachi H., Takai K.;
RT   "Genome sequence of a mesophilic hydrogenotrophic methanogen Methanocella
RT   paludicola, the first cultivated representative of the order
RT   Methanocellales.";
RL   PLoS ONE 6:E22898-E22898(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+)
CC         + NADH; Xref=Rhea:RHEA:12641, ChEBI:CHEBI:15378, ChEBI:CHEBI:18110,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58272; EC=1.1.1.95;
CC         Evidence={ECO:0000256|RuleBase:RU363003};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from
CC       3-phospho-D-glycerate: step 1/3. {ECO:0000256|RuleBase:RU363003}.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU363003}.
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DR   EMBL; AP011532; BAI60467.1; -; Genomic_DNA.
DR   STRING; 304371.MCP_0395; -.
DR   EnsemblBacteria; BAI60467; BAI60467; MCP_0395.
DR   KEGG; mpd:MCP_0395; -.
DR   PATRIC; fig|304371.9.peg.405; -.
DR   eggNOG; arCOG01754; Archaea.
DR   eggNOG; COG0111; LUCA.
DR   HOGENOM; HOG000136693; -.
DR   KO; K00058; -.
DR   OMA; NIAGMQV; -.
DR   UniPathway; UPA00135; UER00196.
DR   Proteomes; UP000001882; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004617; F:phosphoglycerate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006564; P:L-serine biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1330.90; -; 1.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR029009; ASB_dom_sf.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006236; PGDH.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   Pfam; PF01842; ACT; 1.
DR   SUPFAM; SSF143548; SSF143548; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01327; PGDH; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1YVJ5.
DR   SWISS-2DPAGE; D1YVJ5.
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU363003};
KW   Coiled coil {ECO:0000256|SAM:Coils}; NAD {ECO:0000256|RuleBase:RU363003};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU363003};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001882};
KW   Serine biosynthesis {ECO:0000256|RuleBase:RU363003}.
FT   DOMAIN          454..526
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
FT   COILED          33..53
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   526 AA;  56838 MW;  351149E24960263B CRC64;
     MKVLITDPIS DEGIKILKAE PGVQVDVETK LTKEQLLEKI KGYEALIIRS ETQVTKEVIE
     AADSLKIIGR AGVGIDNVDV PAATAKGIIV ANAPEGNTIA ACEHTIAMMF AMSRNIPQAN
     SSLKGGKWER SKFMGVEVLG KTLGIIGMGR IGGEVTKRAR CMGMEVLAQD PFTTPERARD
     LGAKLTTREE IYQKADYITV HTPLIPETRH MISTPQFDMM KKGVRVINCA RGGIIDEAAL
     LEALKSGKVA GAALDVFEKE PPVGSPLLEQ PNVIVTPHLG ASTKEAQISV AVIIAEQVLN
     AFKGLPVTTA LNIPIMKPET MEKIKPFLPL AENLGKFTAQ MVDGRIQEVD ITYSGDITQK
     DVSLITIAAI KGILDFKKGE LVNYVNAKAI AKDYGIKVVE SKSGEVGDYT NLITVTIKTD
     SMQRKVQGTI FGNKDARIVG IDNYRIEANP AGYMIVTMHK DRPGVIGNVG TILGKNDINI
     AGMVVGREAV RGEAIMILNV DDAVPQPVLK EMIEKAGLYD ARYVKL
//

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