(data stored in SCRATCH zone)

SWISSPROT: D1YWF0_METPS

ID   D1YWF0_METPS            Unreviewed;       228 AA.
AC   D1YWF0;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   11-DEC-2019, entry version 52.
DE   RecName: Full=7-cyano-7-deazaguanine synthase {ECO:0000256|HAMAP-Rule:MF_01633};
DE            EC=6.3.4.20 {ECO:0000256|HAMAP-Rule:MF_01633};
DE   AltName: Full=7-cyano-7-carbaguanine synthase {ECO:0000256|HAMAP-Rule:MF_01633};
DE   AltName: Full=Archaeosine biosynthesis protein QueC {ECO:0000256|HAMAP-Rule:MF_01633};
DE   AltName: Full=PreQ(0) synthase {ECO:0000256|HAMAP-Rule:MF_01633};
GN   Name=queC {ECO:0000256|HAMAP-Rule:MF_01633,
GN   ECO:0000313|EMBL:BAI60772.1};
GN   OrderedLocusNames=MCP_0700 {ECO:0000313|EMBL:BAI60772.1};
OS   Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS   SANAE).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI60772.1, ECO:0000313|Proteomes:UP000001882};
RN   [1] {ECO:0000313|Proteomes:UP000001882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC   {ECO:0000313|Proteomes:UP000001882};
RX   PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA   Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA   Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA   Mori K., Fujita N., Imachi H., Takai K.;
RT   "Genome sequence of a mesophilic hydrogenotrophic methanogen Methanocella
RT   paludicola, the first cultivated representative of the order
RT   Methanocellales.";
RL   PLoS ONE 6:E22898-E22898(2011).
CC   -!- FUNCTION: Catalyzes the ATP-dependent conversion of 7-carboxy-7-
CC       deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
CC       {ECO:0000256|HAMAP-Rule:MF_01633}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-
CC         deazaguanine + ADP + H(+) + H2O + phosphate; Xref=Rhea:RHEA:27982,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:45075,
CC         ChEBI:CHEBI:61036, ChEBI:CHEBI:456216; EC=6.3.4.20;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01633};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01633};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-Rule:MF_01633};
CC   -!- PATHWAY: Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_01633}.
CC   -!- SIMILARITY: Belongs to the QueC family. {ECO:0000256|HAMAP-
CC       Rule:MF_01633}.
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DR   EMBL; AP011532; BAI60772.1; -; Genomic_DNA.
DR   STRING; 304371.MCP_0700; -.
DR   EnsemblBacteria; BAI60772; BAI60772; MCP_0700.
DR   KEGG; mpd:MCP_0700; -.
DR   PATRIC; fig|304371.9.peg.724; -.
DR   eggNOG; arCOG00039; Archaea.
DR   eggNOG; COG0603; LUCA.
DR   HOGENOM; HOG000110564; -.
DR   KO; K06920; -.
DR   OMA; VWVPARN; -.
DR   UniPathway; UPA00391; -.
DR   Proteomes; UP000001882; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016879; F:ligase activity, forming carbon-nitrogen bonds; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   CDD; cd01995; ExsB; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_01633; QueC; 1.
DR   InterPro; IPR018317; QueC.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR42914; PTHR42914; 1.
DR   Pfam; PF06508; QueC; 1.
DR   PIRSF; PIRSF006293; ExsB; 1.
DR   TIGRFAMs; TIGR00364; TIGR00364; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1YWF0.
DR   SWISS-2DPAGE; D1YWF0.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_01633};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_01633};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_01633};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01633};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001882};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_01633}.
FT   NP_BIND         8..18
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01633"
FT   METAL           194
FT                   /note="Zinc"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01633"
FT   METAL           202
FT                   /note="Zinc"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01633"
FT   METAL           205
FT                   /note="Zinc"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01633"
FT   METAL           208
FT                   /note="Zinc"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01633"
SQ   SEQUENCE   228 AA;  24748 MW;  D920BFAC2062B67D CRC64;
     MMGSIVLLSS GLDSAVAFKM ALDAFGVDLA LTFDYGQRAA DMEIESAKMI CERFGVRHEV
     IEAPWLEDVT LTALVNRGES VPTPSETELD EIKGKARETA HAVWVPNRNG AFINIAACFA
     DALKVDHIVC GFNAEEGATF PDNTPAFVEA INKSLYYSTE NHAKVIAPVI DMDKVEIIKK
     GMSIDAPLDL SWSCYVSGEK PCGKCESCVR RARAFKRAGV ADPSLVVK
//

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