(data stored in ACNUC4482 zone)

SWISSPROT: D2HHD2_AILME

ID   D2HHD2_AILME            Unreviewed;      1096 AA.
AC   D2HHD2;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   11-DEC-2019, entry version 46.
DE   RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
DE   Flags: Fragment;
GN   ORFNames=PANDA_010506 {ECO:0000313|EMBL:EFB14602.1};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB14602.1};
RN   [1] {ECO:0000313|EMBL:EFB14602.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA   Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA   Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA   Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA   Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA   Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA   Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA   Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA   Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA   Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA   Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA   Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA   Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA   Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA   Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC       {ECO:0000256|SAAS:SAAS01130601}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003762}; Single-
CC       pass type I membrane protein {ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|RuleBase:RU003762, ECO:0000256|SAAS:SAAS00554416}.
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DR   EMBL; GL192839; EFB14602.1; -; Genomic_DNA.
DR   eggNOG; ENOG410IPB9; Eukaryota.
DR   eggNOG; ENOG4110534; LUCA.
DR   HOGENOM; HOG000059610; -.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.130; -; 1.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR013649; Integrin_alpha-2.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF08441; Integrin_alpha2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   SMART; SM00191; Int_alpha; 5.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   SUPFAM; SSF69179; SSF69179; 3.
DR   PROSITE; PS51470; FG_GAP; 7.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
DR   PRODOM; D2HHD2.
DR   SWISS-2DPAGE; D2HHD2.
KW   Cell adhesion {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00440260};
KW   Integrin {ECO:0000256|RuleBase:RU003762, ECO:0000256|SAAS:SAAS00414648};
KW   Membrane {ECO:0000256|SAAS:SAAS00414656};
KW   Receptor {ECO:0000256|RuleBase:RU003762, ECO:0000256|SAAS:SAAS00440269};
KW   Repeat {ECO:0000256|SAAS:SAAS00048613};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00494686};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00414628}.
FT   REPEAT          13..71
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          80..140
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   DOMAIN          153..340
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REPEAT          345..399
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          402..454
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          456..518
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          519..577
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          581..643
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EFB14602.1"
FT   NON_TER         1096
FT                   /evidence="ECO:0000313|EMBL:EFB14602.1"
SQ   SEQUENCE   1096 AA;  120092 MW;  E387BE6B81736714 CRC64;
     GILNCCLAYN VGLLEAKIFS GPSSEQFGYA VQQFINPKGN WLLVGSPWSG FPENRMGDVY
     KCPVDLSTAT CEKLNLETAT SIPNVTEMKT NMSLGLTLTR NMGTGGFLTC GPLWAKQCGS
     QYYTTGVCSD VSADFQLLTS FAPAAQACPS LIDVVVVCDE SNSIYPWEAV KNFLEKFVQS
     LDIGPKKTQV GLIQYANKPR VIFNLNTFKT KAEMIEATSQ TYQYGGDLTN TFKAIQYAKD
     FAYAAGAGGR LGAAKVMVVV TDGESHDGSM LKAVIDQCDN DNILRFGIAV LGYLNRNALD
     TKNLIKEIKA IASIPTETFF FNVSDEAALL EKAGTLGEQI FSIEGTTQGG DNFLTEMSQV
     GFSADYSPQN DILMLGAVGA YDWSGTVVQQ TSHGHLIFPN QAFDQILQDK NHSSYLGYSV
     AAISTGTDIH FVAGAPRANY TGQIVLYSVN ENGNITVIQA HRGDQIGSYF GSVLCSVDVN
     KDTITDVLLV GAPTYMNDLK KEEGRVYLFT ITRGVLNWHQ FLEGPEGVEN ARFGSAIAAL
     SDINMDGFND VIVGSPLENQ NSGAVYIYNG HEGTIRKRYS QKILGSDGAF RSQLQYFGRS
     LDGYGDLNGD SITDVSVGAF GQVVQLWSQS IADVSVDASF TPEKITLFNK NADIKLNLCF
     SAKFRPTKQN DQVAILYNIT IDADLYSSRV TSRGLFKENN ERCLQRNMLV SQAQSCAEYS
     IHIQKLSDIV SSLDLCVNIS LENPGTSPAL EAYSEKAKVF SIPFYQDCGD DGVCISDLVL
     DVQQLSAAQD QAFIVSNQNR RLTFSITLKN KKESAFNTEI VVGFSENLFF ASWSMPVDGT
     EVTCQIASSQ RTITCDVGYP ALKREQQVTF TINFDFNLQS LQNQASVSFQ ASSESHEENE
     ADNSVSFKIP LRYDADIHIT RSTNINFYEV SSDDNVPSIV HSFEDIGPKF TFSIKVTTGS
     VPVSMASVII HIPQYTKEKN PLMYLTGVHT DQAGDISCNA EINPLKIGHT SPSVSFKNEN
     FRHIKELNCR TASCGNVTCW LKDLQVKGEY FLNVSTRIWN GTFAASTFQT VQLTAAAEIN
     TYNPQIYVIE ENTVTV
//

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