(data stored in SCRATCH zone)

SWISSPROT: D3UWG6_XENBS

ID   D3UWG6_XENBS            Unreviewed;       450 AA.
AC   D3UWG6;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   08-MAY-2019, entry version 65.
DE   RecName: Full=Zinc metalloprotease {ECO:0000256|RuleBase:RU362031};
DE            EC=3.4.24.- {ECO:0000256|RuleBase:RU362031};
GN   Name=ecfE {ECO:0000313|EMBL:CBJ79740.1};
GN   OrderedLocusNames=XBJ1_0596 {ECO:0000313|EMBL:CBJ79740.1};
OS   Xenorhabdus bovienii (strain SS-2004).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406818 {ECO:0000313|EMBL:CBJ79740.1, ECO:0000313|Proteomes:UP000002045};
RN   [1] {ECO:0000313|EMBL:CBJ79740.1, ECO:0000313|Proteomes:UP000002045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS-2004 {ECO:0000313|EMBL:CBJ79740.1,
RC   ECO:0000313|Proteomes:UP000002045};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU362031,
CC         ECO:0000256|SAAS:SAAS00913187};
CC   -!- SIMILARITY: Belongs to the peptidase M50B family.
CC       {ECO:0000256|RuleBase:RU362031, ECO:0000256|SAAS:SAAS00563376}.
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DR   EMBL; FN667741; CBJ79740.1; -; Genomic_DNA.
DR   RefSeq; WP_012987194.1; NC_013892.1.
DR   STRING; 406818.XBJ1_0596; -.
DR   MEROPS; M50.004; -.
DR   EnsemblBacteria; CBJ79740; CBJ79740; XBJ1_0596.
DR   GeneID; 8830218; -.
DR   KEGG; xbo:XBJ1_0596; -.
DR   PATRIC; fig|406818.4.peg.549; -.
DR   eggNOG; ENOG4105DZP; Bacteria.
DR   eggNOG; COG0750; LUCA.
DR   HOGENOM; HOG000006281; -.
DR   KO; K11749; -.
DR   OMA; MFLGLFN; -.
DR   BioCyc; XBOV406818:XBJ1_RS02590-MONOMER; -.
DR   Proteomes; UP000002045; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; SSF50156; 2.
DR   TIGRFAMs; TIGR00054; TIGR00054; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
DR   PRODOM; D3UWG6.
DR   SWISS-2DPAGE; D3UWG6.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00462286};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002045};
KW   Hydrolase {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069908, ECO:0000313|EMBL:CBJ79740.1};
KW   Membrane {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069850};
KW   Metal-binding {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00913207};
KW   Metalloprotease {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069945};
KW   Protease {ECO:0000256|SAAS:SAAS00069928, ECO:0000313|EMBL:CBJ79740.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002045};
KW   Transmembrane {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069900};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069864};
KW   Zinc {ECO:0000256|RuleBase:RU362031, ECO:0000256|SAAS:SAAS00090197}.
FT   TRANSMEM      7     28       Helical. {ECO:0000256|RuleBase:RU362031}.
FT   TRANSMEM    105    126       Helical. {ECO:0000256|RuleBase:RU362031}.
FT   TRANSMEM    376    396       Helical. {ECO:0000256|RuleBase:RU362031}.
FT   TRANSMEM    426    444       Helical. {ECO:0000256|RuleBase:RU362031}.
FT   DOMAIN      225    279       PDZ. {ECO:0000259|PROSITE:PS50106}.
SQ   SEQUENCE   450 AA;  49524 MW;  F0E80894954C1BD1 CRC64;
     MDILWNLAAF IVALGILITV HEFGHFWVAR RCGIYVERFS IGFGKALWRR TDKQGTEYVI
     ALIPLGGYVK MLDERVESVS PERRHMAFNN KTIGQRAAVV SAGPIANFIL AVIAYWLVFV
     IGVPSVRPVV LDVKPDSIAA QANILPGMEL KTVDGIETFD WNSVRLALVS KVGESFVSMD
     VMPMDAAASM QKTLDLRDWA FDPSKQDVLL SLGIMPVVPR ISSQVENVYP DSPAEKAGLQ
     RGDRIVKVNG QNVDVWHTFV SFIRKNPNVP LKLDVARANS IIPLSLTPEV RRLSNGREEG
     FAGAELHVIP LADEYKVIQQ YGAFSAIYQA GDKTWQLMKL TVNMIGKLIV GDVKLNNLSG
     PISIAKGAGV SADSGLVYYL MFLALISVNL GIINLFPLPV LDGGHLLFLA IEKIKGGPVS
     ERVQDFSYRI GTILLVLLMG LALFNDFSRF
//

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