(data stored in SCRATCH zone)

SWISSPROT: D3UWH4_XENBS

ID   D3UWH4_XENBS            Unreviewed;      1144 AA.
AC   D3UWH4;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   08-MAY-2019, entry version 56.
DE   RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|SAAS:SAAS01159143};
DE            EC=2.7.7.7 {ECO:0000256|SAAS:SAAS01144005};
GN   Name=dnaE {ECO:0000313|EMBL:CBJ79748.1};
GN   OrderedLocusNames=XBJ1_0604 {ECO:0000313|EMBL:CBJ79748.1};
OS   Xenorhabdus bovienii (strain SS-2004).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406818 {ECO:0000313|EMBL:CBJ79748.1, ECO:0000313|Proteomes:UP000002045};
RN   [1] {ECO:0000313|EMBL:CBJ79748.1, ECO:0000313|Proteomes:UP000002045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS-2004 {ECO:0000313|EMBL:CBJ79748.1,
RC   ECO:0000313|Proteomes:UP000002045};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|SAAS:SAAS01143971};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS01143988}.
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DR   EMBL; FN667741; CBJ79748.1; -; Genomic_DNA.
DR   STRING; 406818.XBJ1_0604; -.
DR   EnsemblBacteria; CBJ79748; CBJ79748; XBJ1_0604.
DR   KEGG; xbo:XBJ1_0604; -.
DR   eggNOG; ENOG4105C0B; Bacteria.
DR   eggNOG; COG0587; LUCA.
DR   HOGENOM; HOG000021784; -.
DR   KO; K02337; -.
DR   OMA; DFCMDGR; -.
DR   Proteomes; UP000002045; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.1600; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   4: Predicted;
DR   PRODOM; D3UWH4.
DR   SWISS-2DPAGE; D3UWH4.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002045};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS01144001};
KW   DNA replication {ECO:0000256|SAAS:SAAS01143938};
KW   DNA-directed DNA polymerase {ECO:0000256|SAAS:SAAS01144000};
KW   Nucleotidyltransferase {ECO:0000256|SAAS:SAAS01143921,
KW   ECO:0000313|EMBL:CBJ79748.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002045};
KW   Transferase {ECO:0000256|SAAS:SAAS01143903,
KW   ECO:0000313|EMBL:CBJ79748.1}.
FT   DOMAIN        1     58       POLIIIAc. {ECO:0000259|SMART:SM00481}.
SQ   SEQUENCE   1144 AA;  128634 MW;  D6E26C2E306AB549 CRC64;
     MIDGLAKTGS LIKKVAKLDM PAFAITDFTN LCGLVKFYGS AHSAGIKPII GADFYVESDL
     LGDEYAHLTI LARNNEGYQN LTFLISEAYQ KGYGAIGPTI KQEWLIKYKA GLILLSGGRM
     GDVGKFLLRG NRAMADQCLD FYQEHFPDSY YLELIRTGRQ DEENYLHAAV EVAAEKNLPV
     VATNDVCFLE SDDFEAHEIR VAIHDGYTMA DPKRPKNYSP QQYLRSEQEM CELFSDIPEA
     LQNSVEIAKR CNVTIRLGEY FLPQFPTGDM STEDYLVEKS KQGLEDRLNF LYPDPQIRAE
     KRSEYDERLD IELEVINQMG FPGYFLIVME FIQWSKDNGV PVGPGRGSGA GSLVAYALKI
     TDIDPLAFDL LFERFLNPER ISMPDFDVDF CMEKRDQVID HVADMYGRDA VSQIITFGTM
     AAKAVIRDVG RVLGHPYGFV DRISKLVPPD PGMTLEKAFA AEPQLPEIYE ADEEVRVLID
     MARKLEGVTR NAGKHAGGVV IAPTKITDFS PIYCDPEGLN PVTQFDKNDV EYAGLVKFDF
     LGLRTLTIIN WALDMVNARR THKNLEPIDI TAIPLDDQIS FDMLQRSETT AVFQLESRGM
     KDLIKRLRPD CFEDMIALVA LFRPGPLQSG MVDNFIDRKH GREELSYPDV EWQHESLKPV
     LEPTYGIILY QEQVMQIAQV LAGYTLGGAD MLRRAMGKKQ PEEMAKQRSV FEEGAISQGI
     NGELAIKIFD LVEKFAGYGF NKSHSAAYAL VSYQTLWLKA HYPAEFMAAV MTADMDNTEK
     VVGLVDECWR MGLKVLPPDI NSGLYHFHVN DESEIVYGIG AIKGVGEGPI EAILEARQKE
     GHFKELFDLC ARVDTKKLNR RVMEKLIMSG AFDRLGPHRA ALMSSLEDAL KAADQHAKAE
     AIGQTDMFGV LAEKPEQVEL SYASTPKWPE QVVLDGERET LGLYLTGHPI TSYLKEIERY
     TNGLRLKDVS PTPRGQVTTV VGLVLASKIL TTKRGNRIGI CTLDDRSGRL EIMLFSDALE
     RYQHLLEQDK ILIATGQVSF DDFSGGLKMT VRELMDISEA REKFARGIAI SLSDRQINKQ
     LFNRLRGVLE PHRSGTIPVH LYYQRVDARA RLRFGATWRV TPTDTLLTDL RTLLGNEQVE
     LEFD
//

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