(data stored in SCRATCH zone)

SWISSPROT: D3UYK6_XENBS

ID   D3UYK6_XENBS            Unreviewed;       702 AA.
AC   D3UYK6;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   08-MAY-2019, entry version 62.
DE   SubName: Full=Bifunctional: (P)ppGpp synthetase II guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase {ECO:0000313|EMBL:CBJ79384.1};
DE            EC=2.7.6.5 {ECO:0000313|EMBL:CBJ79384.1};
DE            EC=3.1.7.2 {ECO:0000313|EMBL:CBJ79384.1};
GN   Name=spoT {ECO:0000313|EMBL:CBJ79384.1};
GN   OrderedLocusNames=XBJ1_0233 {ECO:0000313|EMBL:CBJ79384.1};
OS   Xenorhabdus bovienii (strain SS-2004).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406818 {ECO:0000313|EMBL:CBJ79384.1, ECO:0000313|Proteomes:UP000002045};
RN   [1] {ECO:0000313|Proteomes:UP000002045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS-2004 {ECO:0000313|Proteomes:UP000002045};
RA   Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S.,
RA   Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P.,
RA   Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S.,
RA   Suen G.;
RT   "Complete genome sequence of Xenorhabdus nematophila (strain ATCC
RT   19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6).";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBJ79384.1, ECO:0000313|Proteomes:UP000002045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS-2004 {ECO:0000313|EMBL:CBJ79384.1,
RC   ECO:0000313|Proteomes:UP000002045};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5-'
CC       diphosphate) is a mediator of the stringent response that
CC       coordinates a variety of cellular activities in response to
CC       changes in nutritional abundance. {ECO:0000256|RuleBase:RU003847}.
CC   -!- SIMILARITY: Belongs to the relA/spoT family.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; FN667741; CBJ79384.1; -; Genomic_DNA.
DR   RefSeq; WP_012986847.1; NC_013892.1.
DR   STRING; 406818.XBJ1_0233; -.
DR   EnsemblBacteria; CBJ79384; CBJ79384; XBJ1_0233.
DR   GeneID; 8829856; -.
DR   KEGG; xbo:XBJ1_0233; -.
DR   PATRIC; fig|406818.4.peg.214; -.
DR   eggNOG; ENOG4105CWR; Bacteria.
DR   eggNOG; COG0317; LUCA.
DR   HOGENOM; HOG000018299; -.
DR   KO; K01139; -.
DR   OMA; HYYSIYQ; -.
DR   BioCyc; XBOV406818:XBJ1_RS01010-MONOMER; -.
DR   Proteomes; UP000002045; Chromosome.
DR   GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008893; F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   CDD; cd01668; TGS_RelA_SpoT; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR004811; RelA/Spo_fam.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR033655; TGS_RelA.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF81271; SSF81271; 1.
DR   TIGRFAMs; TIGR00691; spoT_relA; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
DR   PRODOM; D3UYK6.
DR   SWISS-2DPAGE; D3UYK6.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002045};
KW   Hydrolase {ECO:0000313|EMBL:CBJ79384.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002045};
KW   Transferase {ECO:0000313|EMBL:CBJ79384.1}.
FT   DOMAIN       45    144       HD. {ECO:0000259|PROSITE:PS51831}.
FT   DOMAIN      628    702       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   COILED      640    660       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   702 AA;  79040 MW;  C75237330BCD3DD1 CRC64;
     MYLFESLNQL VLKYLPEDQI VLLKQAYVVA RDAHEGQTRS SGEPYITHPV AVSCILAEMR
     LDHETLMAAL LHDVIEDTPA TFQDIEQLFG TAVAGLVEGV SKLDKLNFRN KKEAQAENFR
     KMIMAMVQDI RVILIKLADR THNMRTLGSL RPDKRRRIAR ETLEIYSPLA HRLGIHHLKT
     ELEELGFEAL HPNRYRVIKE VVKAARGNRK EMIQKILSEI EGRLTDAGIQ CTVSGREKHL
     YSIYRKMHLK EQRFHSIMDI YAFRVIVNNL DTCYRVLGQM HSLYKPRPGR VKDYIAIPKA
     NGYQSLHTSL IGPHGVPVEV QIRTEDMDQM AEMGVAAHWA YKEQGESGTT AQIRAQRWMQ
     SLLELQQSAG SSFEFIESVK SDLFPDEIYV FTPEGRIVEL PAGASPVDFA YAVHTDIGHA
     CVGARVDRQP YPLSQTLSSG QTVEIITAPG ARPNAAWLNF VVSSKARAKI RQLLKNLKRD
     DSVGLGRRLL NHALGNGKKI TDIPQESITK ELVRMKLATL DDLLAEIGLG NAMSVVVARN
     LLGATEKIPN NNNSTRKLPI KGADGILITF AKCCRPIPGD PIISHISPGK GLVIHHESCR
     NIRGYQKEPE KFMPVEWDKD VNSDFIAEIK VDMFNHQGAL ANLTAAINDA NSSIQSMNTE
     EKDGRVYCAF IRLTTQDRIQ LANIMRKIRV MPDVMRVSRN RN
//

If you have problems or comments...

PBIL Back to PBIL home page