(data stored in SCRATCH zone)

SWISSPROT: D3VGA8_XENNA

ID   D3VGA8_XENNA            Unreviewed;       460 AA.
AC   D3VGA8;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   08-MAY-2019, entry version 61.
DE   SubName: Full=Sensory histidine kinase in two-component regulatory system with CpxR, regulates genes involved in folding/degrading periplasmic proteins, senses changes in the cell envelope {ECO:0000313|EMBL:CBJ88198.1};
DE            EC=2.7.1.- {ECO:0000313|EMBL:CBJ88198.1};
GN   Name=cpxA {ECO:0000313|EMBL:CBJ88198.1};
GN   OrderedLocusNames=XNC1_0110 {ECO:0000313|EMBL:CBJ88198.1};
OS   Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 /
OS   NCIB 9965 / AN6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406817 {ECO:0000313|EMBL:CBJ88198.1, ECO:0000313|Proteomes:UP000008075};
RN   [1] {ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RA   Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S.,
RA   Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P.,
RA   Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S.,
RA   Suen G.;
RT   "Complete genome sequence of Xenorhabdus nematophila (strain ATCC
RT   19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6).";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBJ88198.1, ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; FN667742; CBJ88198.1; -; Genomic_DNA.
DR   RefSeq; WP_013183087.1; NC_014228.1.
DR   STRING; 406817.XNC1_0110; -.
DR   EnsemblBacteria; CBJ88198; CBJ88198; XNC1_0110.
DR   KEGG; xne:XNC1_0110; -.
DR   eggNOG; ENOG4105E0F; Bacteria.
DR   eggNOG; ENOG410XTWD; LUCA.
DR   HOGENOM; HOG000269851; -.
DR   KO; K07640; -.
DR   OMA; ANDLLWW; -.
DR   Proteomes; UP000008075; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.450.210; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR032404; CpxA_peri.
DR   InterPro; IPR038515; CpxA_peri_sf.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF16527; CpxA_peri; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; D3VGA8.
DR   SWISS-2DPAGE; D3VGA8.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008075};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:CBJ88198.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008075};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669,
KW   ECO:0000313|EMBL:CBJ88198.1};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM    167    186       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      186    239       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      247    457       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   460 AA;  51815 MW;  327620F5F0D0A85E CRC64;
     MINSLTARIF AIFWLTLALV LMVALMAPKL DSRQLTPLLD SEYQQGNKLA KQLEEELTRY
     PANDLFWWLR LDRAIAQLTP PGQSLLLVTS AGNIIDINTP TRQKQVVRNF IGQSDNADHP
     KKKKYGRSEI LGPFSIRDGE DHYQLYFVRP AGSPQSDFIN LMFDRPFLLP AATMLISAPL
     LLWLAWSLAK PARKLKNAAD DVAKGNLRQH PELESGPQEF LATGSSFNQM ISALERMVTA
     QQRLISDISH ELRTPLTRLQ LATALLRRRH GESKELARIE TETQRLDGMI NDLLVLSRNQ
     HKNELLRENI KAYDIWHDIL ENAKFEVEQM NKTLDIVSPP GAWVIYCNPA TLGSALENIV
     RNALRYSDSH IAVAFKADNQ GVTITVDDDG PGVSPEDREQ IFRPFYRTDE ARDRESGGTG
     LGLAIVETAI SQHRGWVKAE DSPLGGLRLV IWLPLHGHGR
//

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