(data stored in SCRATCH zone)

SWISSPROT: D3VHU6_XENNA

ID   D3VHU6_XENNA            Unreviewed;       189 AA.
AC   D3VHU6;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   16-JAN-2019, entry version 58.
DE   RecName: Full=Threonylcarbamoyl-AMP synthase {ECO:0000256|HAMAP-Rule:MF_01852, ECO:0000256|SAAS:SAAS00946452};
DE            Short=TC-AMP synthase {ECO:0000256|HAMAP-Rule:MF_01852};
DE            EC=2.7.7.87 {ECO:0000256|HAMAP-Rule:MF_01852, ECO:0000256|SAAS:SAAS00946446};
DE   AltName: Full=L-threonylcarbamoyladenylate synthase {ECO:0000256|HAMAP-Rule:MF_01852};
DE   AltName: Full=t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC {ECO:0000256|HAMAP-Rule:MF_01852};
DE   AltName: Full=tRNA threonylcarbamoyladenosine biosynthesis protein TsaC {ECO:0000256|HAMAP-Rule:MF_01852};
GN   Name=yrdC {ECO:0000313|EMBL:CBJ88435.1};
GN   Synonyms=tsaC {ECO:0000256|HAMAP-Rule:MF_01852};
GN   OrderedLocusNames=XNC1_0353 {ECO:0000313|EMBL:CBJ88435.1};
OS   Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 /
OS   NCIB 9965 / AN6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406817 {ECO:0000313|EMBL:CBJ88435.1, ECO:0000313|Proteomes:UP000008075};
RN   [1] {ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RA   Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S.,
RA   Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P.,
RA   Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S.,
RA   Suen G.;
RT   "Complete genome sequence of Xenorhabdus nematophila (strain ATCC
RT   19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6).";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBJ88435.1, ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- FUNCTION: Required for the formation of a threonylcarbamoyl group
CC       on adenosine at position 37 (t(6)A37) in tRNAs that read codons
CC       beginning with adenine. Catalyzes the conversion of L-threonine,
CC       HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as
CC       the acyladenylate intermediate, with the release of diphosphate.
CC       {ECO:0000256|HAMAP-Rule:MF_01852, ECO:0000256|SAAS:SAAS00946444}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + hydrogencarbonate + L-threonine = diphosphate + H2O
CC         + L-threonylcarbamoyladenylate; Xref=Rhea:RHEA:36407,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57926, ChEBI:CHEBI:73682;
CC         EC=2.7.7.87; Evidence={ECO:0000256|HAMAP-Rule:MF_01852,
CC         ECO:0000256|SAAS:SAAS01118063};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01852,
CC       ECO:0000256|SAAS:SAAS00946453}.
CC   -!- SIMILARITY: Belongs to the SUA5 family. TsaC subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01852, ECO:0000256|SAAS:SAAS00946451}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; FN667742; CBJ88435.1; -; Genomic_DNA.
DR   RefSeq; WP_013183233.1; NC_014228.1.
DR   STRING; 406817.XNC1_0353; -.
DR   EnsemblBacteria; CBJ88435; CBJ88435; XNC1_0353.
DR   KEGG; xne:XNC1_0353; -.
DR   eggNOG; ENOG4105EK0; Bacteria.
DR   eggNOG; COG0009; LUCA.
DR   HOGENOM; HOG000076163; -.
DR   KO; K07566; -.
DR   OMA; FGLGCNP; -.
DR   Proteomes; UP000008075; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR   GO; GO:0061710; F:L-threonylcarbamoyladenylate synthase; IEA:UniProtKB-EC.
DR   GO; GO:0002949; P:tRNA threonylcarbamoyladenosine modification; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01852; TsaC; 1.
DR   InterPro; IPR017945; DHBP_synth_RibB-like_a/b_dom.
DR   InterPro; IPR023535; TC-AMP_synthase.
DR   InterPro; IPR006070; YrdC-like_dom.
DR   PANTHER; PTHR17490:SF8; PTHR17490:SF8; 1.
DR   Pfam; PF01300; Sua5_yciO_yrdC; 1.
DR   SUPFAM; SSF55821; SSF55821; 1.
DR   PROSITE; PS51163; YRDC; 1.
PE   3: Inferred from homology;
DR   PRODOM; D3VHU6.
DR   SWISS-2DPAGE; D3VHU6.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_01852,
KW   ECO:0000256|SAAS:SAAS00946442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008075};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01852,
KW   ECO:0000256|SAAS:SAAS00946450};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01852,
KW   ECO:0000256|SAAS:SAAS00946447};
KW   Nucleotidyltransferase {ECO:0000256|HAMAP-Rule:MF_01852,
KW   ECO:0000256|SAAS:SAAS00946443};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008075};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_01852,
KW   ECO:0000256|SAAS:SAAS00946445};
KW   tRNA processing {ECO:0000256|HAMAP-Rule:MF_01852,
KW   ECO:0000256|SAAS:SAAS00946448}.
FT   DOMAIN        6    189       YrdC-like. {ECO:0000259|PROSITE:PS51163}.
SQ   SEQUENCE   189 AA;  20894 MW;  8651BC826A86D930 CRC64;
     MSNEISPAFD SIVTALKEGK VIAYPTEAVF GLGCDPDSEN AVQELLALKN RPWEKGLILI
     ADNYERLCSY IDDVQLSDEQ KETIFSFWPG PVTWVIPAKK ITPKWLTGKF STLAVRVTDH
     PLVKQLCSLY GKPLVSTSAN LSGLEPCRSV EEVRLQFGNR IPVLSGEVGG RKNPSEIRDA
     LTGKLYRQG
//

If you have problems or comments...

PBIL Back to PBIL home page