(data stored in SCRATCH zone)

SWISSPROT: D3VIL9_XENNA

ID   D3VIL9_XENNA            Unreviewed;       158 AA.
AC   D3VIL9;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   16-JAN-2019, entry version 64.
DE   RecName: Full=Transcription elongation factor GreA {ECO:0000256|HAMAP-Rule:MF_00105, ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS01033802};
DE   AltName: Full=Transcript cleavage factor GreA {ECO:0000256|HAMAP-Rule:MF_00105};
GN   Name=greA {ECO:0000256|HAMAP-Rule:MF_00105,
GN   ECO:0000313|EMBL:CBJ88569.1};
GN   OrderedLocusNames=XNC1_0495 {ECO:0000313|EMBL:CBJ88569.1};
OS   Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 /
OS   NCIB 9965 / AN6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406817 {ECO:0000313|EMBL:CBJ88569.1, ECO:0000313|Proteomes:UP000008075};
RN   [1] {ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RA   Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S.,
RA   Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P.,
RA   Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S.,
RA   Suen G.;
RT   "Complete genome sequence of Xenorhabdus nematophila (strain ATCC
RT   19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6).";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBJ88569.1, ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC       elongation past template-encoded arresting sites. The arresting
CC       sites in DNA have the property of trapping a certain fraction of
CC       elongating RNA polymerases that pass through, resulting in locked
CC       ternary complexes. Cleavage of the nascent transcript by cleavage
CC       factors such as GreA or GreB allows the resumption of elongation
CC       from the new 3'terminus. GreA releases sequences of 2 to 3
CC       nucleotides. {ECO:0000256|HAMAP-Rule:MF_00105,
CC       ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS01033799}.
CC   -!- SIMILARITY: Belongs to the GreA/GreB family. {ECO:0000256|HAMAP-
CC       Rule:MF_00105, ECO:0000256|RuleBase:RU000556,
CC       ECO:0000256|SAAS:SAAS01033218}.
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DR   EMBL; FN667742; CBJ88569.1; -; Genomic_DNA.
DR   RefSeq; WP_010845215.1; NC_014228.1.
DR   STRING; 406817.XNC1_0495; -.
DR   EnsemblBacteria; CBJ88569; CBJ88569; XNC1_0495.
DR   KEGG; xne:XNC1_0495; -.
DR   eggNOG; ENOG4108UKH; Bacteria.
DR   eggNOG; COG0782; LUCA.
DR   HOGENOM; HOG000241145; -.
DR   KO; K03624; -.
DR   OMA; TWLTQEA; -.
DR   Proteomes; UP000008075; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.180; -; 1.
DR   Gene3D; 3.10.50.30; -; 1.
DR   HAMAP; MF_00105; GreA_GreB; 1.
DR   InterPro; IPR036953; GreA/GreB_C_sf.
DR   InterPro; IPR018151; TF_GreA/GreB_CS.
DR   InterPro; IPR006359; Tscrpt_elong_fac_GreA.
DR   InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR   InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR   InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR   InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR   InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR   PANTHER; PTHR30437; PTHR30437; 1.
DR   Pfam; PF01272; GreA_GreB; 1.
DR   Pfam; PF03449; GreA_GreB_N; 1.
DR   PIRSF; PIRSF006092; GreA_GreB; 1.
DR   SUPFAM; SSF46557; SSF46557; 1.
DR   TIGRFAMs; TIGR01462; greA; 1.
DR   PROSITE; PS00829; GREAB_1; 1.
DR   PROSITE; PS00830; GREAB_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; D3VIL9.
DR   SWISS-2DPAGE; D3VIL9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008075};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00105,
KW   ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS01033224};
KW   Elongation factor {ECO:0000313|EMBL:CBJ88569.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:CBJ88569.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008075};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00105,
KW   ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS01033216};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00105,
KW   ECO:0000256|RuleBase:RU000556, ECO:0000256|SAAS:SAAS01033223}.
FT   DOMAIN        4     74       GreA_GreB_N. {ECO:0000259|Pfam:PF03449}.
FT   DOMAIN       83    157       GreA_GreB. {ECO:0000259|Pfam:PF01272}.
SQ   SEQUENCE   158 AA;  17586 MW;  37525A87A7BB46D1 CRC64;
     MKQIPMTVRG ADKLREELEH LRNVRRPQII TAIADAREHG DLKENAEYHA AREQQGFCEG
     RIQEIEAKLS NAQVIDVTKM TNNGRVIFGA TVTVLNVDSD EEQTYRIVGD DEANIKENLL
     SVNSPIARGL IGKEVDDAVV IATPGGQVEY EVLNVDYL
//

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