(data stored in SCRATCH zone)

SWISSPROT: D4YX45_SPHJU

ID   D4YX45_SPHJU            Unreviewed;       300 AA.
AC   D4YX45;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   07-JUN-2017, entry version 48.
DE   RecName: Full=4-hydroxybenzoate octaprenyltransferase {ECO:0000256|SAAS:SAAS00719688};
DE            EC=2.5.1.- {ECO:0000256|SAAS:SAAS00336940};
GN   Name=ubiA {ECO:0000313|EMBL:BAI94927.1};
GN   OrderedLocusNames=SJA_C1-00930 {ECO:0000313|EMBL:BAI94927.1};
OS   Sphingobium japonicum (strain NBRC 101211 / UT26S).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=452662 {ECO:0000313|EMBL:BAI94927.1, ECO:0000313|Proteomes:UP000007753};
RN   [1] {ECO:0000313|EMBL:BAI94927.1, ECO:0000313|Proteomes:UP000007753}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101211 / UT26S {ECO:0000313|Proteomes:UP000007753};
RX   PubMed=20817768; DOI=10.1128/JB.00961-10;
RA   Nagata Y., Ohtsubo Y., Endo R., Ichikawa N., Ankai A., Oguchi A.,
RA   Fukui S., Fujita N., Tsuda M.;
RT   "Complete genome sequence of the representative gamma-
RT   hexachlorocyclohexane-degrading bacterium Sphingobium japonicum
RT   UT26.";
RL   J. Bacteriol. 192:5852-5853(2010).
CC   -!- FUNCTION: Catalyzes the prenylation of para-hydroxybenzoate (PHB)
CC       with an all-trans polyprenyl group. Mediates the second step in
CC       the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis,
CC       which is the condensation of the polyisoprenoid side chain with
CC       PHB, generating the first membrane-bound Q intermediate 3-
CC       octaprenyl-4-hydroxybenzoate. {ECO:0000256|SAAS:SAAS00719725}.
CC   -!- CATALYTIC ACTIVITY: 4-hydroxybenzoate + farnesylfarnesylgeraniol =
CC       3-octaprenyl-4-hydroxybenzoate. {ECO:0000256|SAAS:SAAS00719654}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS00377743};
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000256|SAAS:SAAS00188628}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|SAAS:SAAS00763190}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00763190}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       {ECO:0000256|SAAS:SAAS00566682}.
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DR   EMBL; AP010803; BAI94927.1; -; Genomic_DNA.
DR   RefSeq; WP_013038755.1; NC_014006.1.
DR   STRING; 452662.SJA_C1-00930; -.
DR   EnsemblBacteria; BAI94927; BAI94927; SJA_C1-00930.
DR   GeneID; 29271805; -.
DR   KEGG; sjp:SJA_C1-00930; -.
DR   eggNOG; ENOG4105C4G; Bacteria.
DR   eggNOG; COG0382; LUCA.
DR   HOGENOM; HOG000003697; -.
DR   KO; K03179; -.
DR   OMA; WTLGFDT; -.
DR   OrthoDB; POG091H03R0; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000007753; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004659; F:prenyltransferase activity; IEA:InterPro.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006370; HB_polyprenyltransferase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR030470; UbiA_prenylTrfase_CS.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01474; ubiA_proteo; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
DR   PRODOM; D4YX45.
DR   SWISS-2DPAGE; D4YX45.
KW   Cell inner membrane {ECO:0000256|SAAS:SAAS00763179};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00763187};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007753};
KW   Magnesium {ECO:0000256|SAAS:SAAS00763194};
KW   Membrane {ECO:0000256|SAAS:SAAS00415574, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007753};
KW   Transferase {ECO:0000256|SAAS:SAAS00415579,
KW   ECO:0000313|EMBL:BAI94927.1};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00415577,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00415562,
KW   ECO:0000256|SAM:Phobius};
KW   Ubiquinone biosynthesis {ECO:0000256|SAAS:SAAS00415585}.
FT   TRANSMEM     35     54       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     60     82       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    103    123       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    129    146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    182    201       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    243       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   300 AA;  32251 MW;  9E8DD2C7CEA2B064 CRC64;
     MTSSILPDSE DRGLVARLPD LPRALALLAR FDRPIGWWLL FWPGAWAVAL AGGAGQRWPL
     ILWLLLGSIA MRGAGCVFND IVDRGLDRQV ARTASRPLAS GAVSLRTAWI WLLSLCLVGL
     AVLLQLHPYA QVVALGSLAL VAAYPFMKRI TGWPQIWLGL VFSWAALVGW SEVAGTLAMP
     GLLLYGGCIV WVVGYDTIYA LQDREDDALI GIGSSALSMG RHVRAGVALC YALALALWGG
     AIWQVRPQGL ALAALLPMAA HLAWQVATLK EDGMDPLVKF RSNRFAGLLM FLGCLVVGSA
//

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