(data stored in SCRATCH zone)

SWISSPROT: D4YYK4_SPHJU

ID   D4YYK4_SPHJU            Unreviewed;       348 AA.
AC   D4YYK4;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   08-MAY-2019, entry version 58.
DE   RecName: Full=Heme A synthase {ECO:0000256|HAMAP-Rule:MF_01665};
DE            Short=HAS {ECO:0000256|HAMAP-Rule:MF_01665};
DE            EC=1.3.-.- {ECO:0000256|HAMAP-Rule:MF_01665};
DE   AltName: Full=Cytochrome aa3-controlling protein {ECO:0000256|HAMAP-Rule:MF_01665};
GN   Name=cox15 {ECO:0000313|EMBL:BAI95436.1};
GN   Synonyms=ctaA {ECO:0000256|HAMAP-Rule:MF_01665};
GN   OrderedLocusNames=SJA_C1-06020 {ECO:0000313|EMBL:BAI95436.1};
OS   Sphingobium japonicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26
OS   / NBRC 101211 / UT26S).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=452662 {ECO:0000313|EMBL:BAI95436.1, ECO:0000313|Proteomes:UP000007753};
RN   [1] {ECO:0000313|EMBL:BAI95436.1, ECO:0000313|Proteomes:UP000007753}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S
RC   {ECO:0000313|Proteomes:UP000007753};
RX   PubMed=20817768; DOI=10.1128/JB.00961-10;
RA   Nagata Y., Ohtsubo Y., Endo R., Ichikawa N., Ankai A., Oguchi A.,
RA   Fukui S., Fujita N., Tsuda M.;
RT   "Complete genome sequence of the representative gamma-
RT   hexachlorocyclohexane-degrading bacterium Sphingobium japonicum
RT   UT26.";
RL   J. Bacteriol. 192:5852-5853(2010).
CC   -!- FUNCTION: Catalyzes the oxidation of the C8 methyl side group on
CC       heme O porphyrin ring into a formyl group. {ECO:0000256|HAMAP-
CC       Rule:MF_01665}.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; heme A
CC       biosynthesis; heme A from heme O: step 1/1. {ECO:0000256|HAMAP-
CC       Rule:MF_01665}.
CC   -!- SUBUNIT: Interacts with CtaB. {ECO:0000256|HAMAP-Rule:MF_01665}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01665, ECO:0000256|SAAS:SAAS00771040}; Multi-pass membrane
CC       protein {ECO:0000256|HAMAP-Rule:MF_01665,
CC       ECO:0000256|SAAS:SAAS00771040}.
CC   -!- SIMILARITY: Belongs to the COX15/CtaA family. Type 2 subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01665}.
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DR   EMBL; AP010803; BAI95436.1; -; Genomic_DNA.
DR   RefSeq; WP_013039154.1; NC_014006.1.
DR   STRING; 452662.SJA_C1-06020; -.
DR   EnsemblBacteria; BAI95436; BAI95436; SJA_C1-06020.
DR   GeneID; 29272278; -.
DR   KEGG; sjp:SJA_C1-06020; -.
DR   eggNOG; ENOG4107TQK; Bacteria.
DR   eggNOG; COG1612; LUCA.
DR   HOGENOM; HOG000214943; -.
DR   KO; K02259; -.
DR   OMA; LIYNTFP; -.
DR   UniPathway; UPA00269; UER00713.
DR   Proteomes; UP000007753; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR   GO; GO:0006784; P:heme a biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01665; HemeA_synth_type2; 1.
DR   InterPro; IPR003780; COX15/CtaA_fam.
DR   InterPro; IPR023754; HemeA_Synthase_type2.
DR   PANTHER; PTHR23289; PTHR23289; 1.
DR   Pfam; PF02628; COX15-CtaA; 1.
PE   3: Inferred from homology;
DR   PRODOM; D4YYK4.
DR   SWISS-2DPAGE; D4YYK4.
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01665};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007753};
KW   Heme biosynthesis {ECO:0000256|HAMAP-Rule:MF_01665};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01665,
KW   ECO:0000256|SAAS:SAAS00464214};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_01665};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007753};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01665,
KW   ECO:0000256|SAAS:SAAS00464244};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01665,
KW   ECO:0000256|SAAS:SAAS00464258}.
FT   TRANSMEM     20     39       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01665}.
FT   TRANSMEM    104    122       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01665}.
FT   TRANSMEM    134    152       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01665}.
FT   TRANSMEM    167    189       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01665}.
FT   TRANSMEM    201    226       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01665}.
FT   TRANSMEM    262    284       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01665}.
FT   TRANSMEM    296    317       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01665}.
FT   TRANSMEM    323    343       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01665}.
FT   BINDING     325    325       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_01665}.
SQ   SEQUENCE   348 AA;  38020 MW;  666A776EFA971473 CRC64;
     MTATTLSRPA TAVPRPAPIA RWLLTVAALV FCMVVVGGIT RLTESGLSIT QWKPIAGAIP
     PLTHDQWMQA FRDYQKIPEY RQLRQGMTLG DFQFIFFWEW VHRLLGRLIG LAFALPLIWF
     AWKRAIPQGY GLRLVALLAL GGLQGAIGWW MVESGLSERT DVSHYRLAVH LLTALFIMGG
     LIWTALDLLT RAKTPFAKPA MLHPFAVVAL LALLAQLMFG AFTAGLDAGY VSSTWPLMND
     HLVPRGIEWL GSLWATVSSD PYLVHFIHRW WAWGVAILLV MLARMARQAG QRGPSIAINA
     TVGAQIALGI ATVVSGMALP LAVLHQAVGA LVVASAAWGA HALGERRG
//

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