(data stored in SCRATCH zone)

SWISSPROT: D5E8Y6_METMS

ID   D5E8Y6_METMS            Unreviewed;      1241 AA.
AC   D5E8Y6;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   11-DEC-2019, entry version 46.
DE   SubName: Full=Peptidase S8 and S53 subtilisin kexin sedolisin {ECO:0000313|EMBL:ADE35645.1};
DE   Flags: Precursor;
GN   OrderedLocusNames=Mmah_0109 {ECO:0000313|EMBL:ADE35645.1};
OS   Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX   NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE35645.1, ECO:0000313|Proteomes:UP000001059};
RN   [1] {ECO:0000313|EMBL:ADE35645.1, ECO:0000313|Proteomes:UP000001059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35705 / DSM 5219 / SLP
RC   {ECO:0000313|Proteomes:UP000001059};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Methanohalophilus mahii DSM 5219.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP001994; ADE35645.1; -; Genomic_DNA.
DR   RefSeq; WP_013036588.1; NC_014002.1.
DR   EnsemblBacteria; ADE35645; ADE35645; Mmah_0109.
DR   GeneID; 8982240; -.
DR   KEGG; mmh:Mmah_0109; -.
DR   eggNOG; arCOG00702; Archaea.
DR   eggNOG; arCOG02480; Archaea.
DR   eggNOG; arCOG02538; Archaea.
DR   eggNOG; arCOG05978; Archaea.
DR   eggNOG; COG1404; LUCA.
DR   eggNOG; COG3291; LUCA.
DR   HOGENOM; HOG000121506; -.
DR   OMA; YCANDAC; -.
DR   OrthoDB; 22639at2157; -.
DR   BioCyc; MMAH547558:G1GHT-108-MONOMER; -.
DR   Proteomes; UP000001059; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd04842; Peptidases_S8_Kp43_protease; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR026453; PGF_pre_PGF.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR034058; TagA/B/C/D_pept_dom.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SMART; SM00089; PKD; 1.
DR   SUPFAM; SSF49299; SSF49299; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   TIGRFAMs; TIGR04213; PGF_pre_PGF; 1.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS50093; PKD; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   4: Predicted;
DR   PRODOM; D5E8Y6.
DR   SWISS-2DPAGE; D5E8Y6.
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001059};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1220..1237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          753..842
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          954..1011
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          411..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1198..1218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1241 AA;  136020 MW;  87F5EAF1BA73BCA5 CRC64;
     MGIPHSFLAF SIKEVIYIIN QMKMMDYRVV SVTILFLLLC SFFTCSAALA KNSDTPFDHI
     FLKNATINPG QTPLVGTNTV TISNDGSKGY YLVQFQNPIL PDWKVQIEKI SEISGYVPEN
     TYILHLNGSQ INRIKSLPYF KWMGEYKPEY KVDPDLYGLD GETIIVISTF KSNSAELKNS
     LLEMDASLVA ENGNQIRVKI NGSVIPLIAQ CANVVWIEPY NPPVILNDKA GEIIGVDRVA
     SPHNLTGANQ TIAIADTGLD TGNLSTLHPD IGGRVDALYD WSDGNPADNN GHGTHVAGSA
     LGNGYLSAGQ YKGMAPEAHL FFQACGDGSK TLNIPPLNQL FIEAYNNGSR IHSNSWGSSS
     SYATDAKALD NFTWHHPDML ILFAAGNDGP STGTINSPGI AKNALTVGAS ENYRPERGGD
     SDNPSDIADF SSRGPTFDGR IKPDIVTPGT SIYSTASSLV YPEDYVYMSG TSMATPVTAG
     SAALIRQYFM NNIPIHPSAA LLKATLINGA VDLNHSYYSQ GWGRLDLTKS IDPVFPAHIR
     LHDNINLSTN TSWTAKYYVD NTQTPLKATL VWTDYPATAS ASKALVNNLD LVITSPNYSK
     YYGNGAPDNV NNVEQIQIDS PEAGWYSFSV NGTKVPQGSE QPFAFVISGG SLNNETVVKK
     ATVEPESIGA SGPENAILKV ELNEHLVNSA VYADLSQLGL PSQQNLTNNS GIWEYELNSK
     SEGTYYFGIN VTYNESSYDN STFVKLNIID NIPPANVTDL YPVNTGYSWI NWSWTNPNDS
     DFSNSLVYID GIQEATLNRT HYNATGLFPN TSHTISIRTV DNNGNINQNW TNNTSGTQTD
     VIYPQIHDIM VNNSENLTAG ELLEITVNST DDYMLSEVLA NGKQLSNLEG TLWRGNLVIL
     PGMQYINISA MDTSGNKVWN NSTCYSGLIM PQAHFTSNVT SGKVPLSVQF NDTSHNATEW
     NWDIDGDSSI DYAIQNPSHV YNKTGAYSVT LTVNNTNGTD TYSFENYIEV EPRNPATNGG
     GSGGGGGSTT AEDYSNIIFK DFSIRSITVD EPVTYEFKEP KNPVRQIDLI SARNAGQVKF
     TVELLKNTSS LVNKPSAGLV YHNLNIWAEN SAFSENIQNS SVIFRIDQDW FDQENVDVKD
     IVLEVFENGT WIALPTEYIN KSTNYLYFKA DTDRYLNAPF VIMGTEYIKE IEEPIAEKPE
     LEPQSEKESQ SENQDAQTPG FTGMFVVALI AGAALVMRKR I
//

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