(data stored in SCRATCH zone)

SWISSPROT: D5E919_METMS

ID   D5E919_METMS            Unreviewed;       319 AA.
AC   D5E919;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   11-DEC-2019, entry version 56.
DE   RecName: Full=Beta-ribofuranosylaminobenzene 5'-phosphate synthase {ECO:0000256|PIRNR:PIRNR004884};
DE            Short=Beta-RFA-P synthase {ECO:0000256|PIRNR:PIRNR004884};
DE            EC=2.4.2.54 {ECO:0000256|PIRNR:PIRNR004884};
GN   OrderedLocusNames=Mmah_0135 {ECO:0000313|EMBL:ADE35670.1};
OS   Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX   NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE35670.1, ECO:0000313|Proteomes:UP000001059};
RN   [1] {ECO:0000313|EMBL:ADE35670.1, ECO:0000313|Proteomes:UP000001059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35705 / DSM 5219 / SLP
RC   {ECO:0000313|Proteomes:UP000001059};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Methanohalophilus mahii DSM 5219.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-
CC       phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-
CC       ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
CC       {ECO:0000256|PIRNR:PIRNR004884}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate +
CC         H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 +
CC         diphosphate; Xref=Rhea:RHEA:48556, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58017, ChEBI:CHEBI:82767; EC=2.4.2.54;
CC         Evidence={ECO:0000256|PIRNR:PIRNR004884};
CC   -!- PATHWAY: Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin
CC       biosynthesis. {ECO:0000256|PIRNR:PIRNR004884}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR004884}.
CC   -!- SIMILARITY: Belongs to the beta-RFA-P synthase family.
CC       {ECO:0000256|PIRNR:PIRNR004884}.
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DR   EMBL; CP001994; ADE35670.1; -; Genomic_DNA.
DR   RefSeq; WP_013036613.1; NC_014002.1.
DR   EnsemblBacteria; ADE35670; ADE35670; Mmah_0135.
DR   GeneID; 8982266; -.
DR   KEGG; mmh:Mmah_0135; -.
DR   eggNOG; arCOG01026; Archaea.
DR   eggNOG; COG1907; LUCA.
DR   HOGENOM; HOG000232305; -.
DR   KO; K06984; -.
DR   OMA; IWEIEFR; -.
DR   OrthoDB; 47243at2157; -.
DR   BioCyc; MMAH547558:G1GHT-134-MONOMER; -.
DR   UniPathway; UPA00065; -.
DR   Proteomes; UP000001059; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016757; F:transferase activity, transferring glycosyl groups; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.230.10; -; 1.
DR   InterPro; IPR013750; GHMP_kinase_C_dom.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR004422; RFAPS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR20861:SF6; PTHR20861:SF6; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF004884; Sugar_kin_arch; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   TIGRFAMs; TIGR00144; beta_RFAP_syn; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5E919.
DR   SWISS-2DPAGE; D5E919.
KW   Glycosyltransferase {ECO:0000256|PIRNR:PIRNR004884};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001059};
KW   Transferase {ECO:0000256|PIRNR:PIRNR004884}.
FT   DOMAIN          75..135
FT                   /note="GHMP_kinases_N"
FT                   /evidence="ECO:0000259|Pfam:PF00288"
FT   DOMAIN          215..296
FT                   /note="GHMP_kinases_C"
FT                   /evidence="ECO:0000259|Pfam:PF08544"
SQ   SEQUENCE   319 AA;  34200 MW;  FC105235318DD48A CRC64;
     MIEITSPSRL HLSLIDLNAS LGRVDGGIGV SLQYPHIHLT AEKSDHLEIT GNSLLYDKVQ
     SAISALLPEG EGISIYLDED MPAHVGLGSG TQVALCTAAA INELFELGFS IRQLAQKVGR
     GGTSGIGVAA FEKGGFLVDG GHRFSDKGTF SPSSASPAPP APIVFRHDFP DWPIVLALPD
     RQGAHDAQEV DIFRQVCPVP LEDVQAISHI VLMQMIPAVI ENDIENFGIA LDSLQTLGFK
     KQEISLQSQQ VQDVIEQMRL AGTHGVGMSS FGPAICGFVE NETKGKRIVR EIQKFLDESI
     GGKVLLTTPN NTGADIRMD
//

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