(data stored in SCRATCH zone)

SWISSPROT: D5E929_METMS

ID   D5E929_METMS            Unreviewed;       573 AA.
AC   D5E929;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   11-DEC-2019, entry version 40.
DE   SubName: Full=Acetolactate synthase, large subunit {ECO:0000313|EMBL:ADE35680.1};
DE            EC=2.2.1.6 {ECO:0000313|EMBL:ADE35680.1};
GN   OrderedLocusNames=Mmah_0145 {ECO:0000313|EMBL:ADE35680.1};
OS   Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX   NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE35680.1, ECO:0000313|Proteomes:UP000001059};
RN   [1] {ECO:0000313|EMBL:ADE35680.1, ECO:0000313|Proteomes:UP000001059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35705 / DSM 5219 / SLP
RC   {ECO:0000313|Proteomes:UP000001059};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Methanohalophilus mahii DSM 5219.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; CP001994; ADE35680.1; -; Genomic_DNA.
DR   RefSeq; WP_013036623.1; NC_014002.1.
DR   EnsemblBacteria; ADE35680; ADE35680; Mmah_0145.
DR   GeneID; 8982276; -.
DR   KEGG; mmh:Mmah_0145; -.
DR   eggNOG; arCOG01998; Archaea.
DR   eggNOG; COG0028; LUCA.
DR   HOGENOM; HOG000258448; -.
DR   KO; K01652; -.
DR   OMA; GNHQMLA; -.
DR   OrthoDB; 7134at2157; -.
DR   BioCyc; MMAH547558:G1GHT-144-MONOMER; -.
DR   Proteomes; UP000001059; Chromosome.
DR   GO; GO:0003984; F:acetolactate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5E929.
DR   SWISS-2DPAGE; D5E929.
KW   Reference proteome {ECO:0000313|Proteomes:UP000001059};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132};
KW   Transferase {ECO:0000313|EMBL:ADE35680.1}.
FT   DOMAIN          4..170
FT                   /note="TPP_enzyme_N"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          199..329
FT                   /note="TPP_enzyme_M"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          391..540
FT                   /note="TPP_enzyme_C"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   573 AA;  63429 MW;  70BF4D3D750E150B CRC64;
     MEKMNGAQVL VKCLEDLGVK HVFGYTGAAI LPVFHALHDS DIGITISSNE QSAAFSAAGY
     SRSGDEIGVA MVTSGPAITN TLTGVADAYG DSIPMLVFAG QVPEHKIGTD SFQHINVSGI
     FEDAAKKVIQ LSNNDDIESI VKDAYYFACS GKPGPVVIDF PLDKQQKRHE YRARDVSIFE
     QSYHDDRHLS DRQCAGFYEL LLNSEKPLLY LGGGLNSRRG RQAIHAFNDY FKIPSVNTLM
     AKGIVDERDE LNLGMLGMFG TPYANMIIQE NDFFFAIGVR WDDRIAEKVG FGIEAEIAYI
     DINPEKMHQI KIERFPKFTF IGDAATALGD LLAYAKRYNI KLDIGRWQKH AAKLKQSWPL
     DYNRSSDRIQ AAETMGMLAG FIDETMKITT GVGNHQMLAA QYLPMQQEQS FMSSGSFGTM
     GFAVPTAIGV HYANPNSKVI AIDGDGSLKM NLGELHTIAS LDLPVKILLL NNMSDGMVLN
     LQDVAYGGIR TGTRRTKDIL FAEIARSFGF NYSKRVNKRK ELRQSLEYFL DAEGPSFLEV
     LTDREEILYP KVPAGCSYSD MIIGPYIKKV SSD
//

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