(data stored in SCRATCH zone)

SWISSPROT: D5EA01_METMS

ID   D5EA01_METMS            Unreviewed;       345 AA.
AC   D5EA01;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   11-DEC-2019, entry version 47.
DE   SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:ADE36002.1};
GN   OrderedLocusNames=Mmah_0473 {ECO:0000313|EMBL:ADE36002.1};
OS   Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX   NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE36002.1, ECO:0000313|Proteomes:UP000001059};
RN   [1] {ECO:0000313|EMBL:ADE36002.1, ECO:0000313|Proteomes:UP000001059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35705 / DSM 5219 / SLP
RC   {ECO:0000313|Proteomes:UP000001059};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Methanohalophilus mahii DSM 5219.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|PIRSR:PIRSR004869-50};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.
CC       {ECO:0000256|PIRSR:PIRSR004869-50};
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DR   EMBL; CP001994; ADE36002.1; -; Genomic_DNA.
DR   RefSeq; WP_013036945.1; NC_014002.1.
DR   EnsemblBacteria; ADE36002; ADE36002; Mmah_0473.
DR   GeneID; 8982614; -.
DR   KEGG; mmh:Mmah_0473; -.
DR   eggNOG; arCOG00934; Archaea.
DR   eggNOG; COG1313; LUCA.
DR   HOGENOM; HOG000229606; -.
DR   KO; K04070; -.
DR   OMA; WNSNMYM; -.
DR   OrthoDB; 34153at2157; -.
DR   BioCyc; MMAH547558:G1GHT-473-MONOMER; -.
DR   Proteomes; UP000001059; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR040085; MJ0674-like.
DR   InterPro; IPR016431; Pyrv-formate_lyase-activ_prd.
DR   InterPro; IPR007197; rSAM.
DR   PANTHER; PTHR43075; PTHR43075; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   PIRSF; PIRSF004869; PflX_prd; 1.
DR   SFLD; SFLDG01099; Uncharacterised_Radical_SAM_Su; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
PE   4: Predicted;
DR   PRODOM; D5EA01.
DR   SWISS-2DPAGE; D5EA01.
KW   Iron {ECO:0000256|PIRSR:PIRSR004869-50};
KW   Iron-sulfur {ECO:0000256|PIRSR:PIRSR004869-50};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR004869-50};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001059};
KW   S-adenosyl-L-methionine {ECO:0000256|PIRSR:PIRSR004869-50}.
FT   DOMAIN          137..279
FT                   /note="Radical_SAM"
FT                   /evidence="ECO:0000259|Pfam:PF04055"
FT   METAL           142
FT                   /note="Iron-sulfur (4Fe-4S-S-AdoMet)"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR004869-50"
FT   METAL           146
FT                   /note="Iron-sulfur (4Fe-4S-S-AdoMet)"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR004869-50"
FT   METAL           149
FT                   /note="Iron-sulfur (4Fe-4S-S-AdoMet)"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR004869-50"
SQ   SEQUENCE   345 AA;  40356 MW;  8E1B1F4CC60416B5 CRC64;
     MDSPKFLNRY HAVTNNQLPA QFQIVKSIPT RYDISKSLDE LWNIHERSME QYRSLLDLID
     SEKRYPEKLT AACTSLLDLK IAIAEKLIEK CCLCEHRCDV NRKRDEKGFC RLTETSRYTS
     EFLHMGEESE LVPSHTIFFT GCVFGCVYCQ NWDISAYPEK GHQVNPANLA AIIRERRHSG
     ARNVNFVTPT PHAHNILKIL REVSVNIPVI WNSNMYHTRE IAKLLEGVID VYLTDFKYGS
     DRCAKKYSKV QNYLEIVKRN HEIAYQKAEI IIRHLVLPEH LECCTKPVVR WIAKHVPEVR
     FNLMFQYTPQ YRSREYPEIS RRLLPDEKEK AIAIVKESGI EDILI
//

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