(data stored in SCRATCH zone)

SWISSPROT: D5EA15_METMS

ID   D5EA15_METMS            Unreviewed;       408 AA.
AC   D5EA15;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   11-DEC-2019, entry version 54.
DE   RecName: Full=Translation initiation factor 2 subunit gamma {ECO:0000256|HAMAP-Rule:MF_00119};
DE   AltName: Full=aIF2-gamma {ECO:0000256|HAMAP-Rule:MF_00119};
DE   AltName: Full=eIF-2-gamma {ECO:0000256|HAMAP-Rule:MF_00119};
GN   Name=eif2g {ECO:0000256|HAMAP-Rule:MF_00119};
GN   OrderedLocusNames=Mmah_0488 {ECO:0000313|EMBL:ADE36016.1};
OS   Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanohalophilus.
OX   NCBI_TaxID=547558 {ECO:0000313|EMBL:ADE36016.1, ECO:0000313|Proteomes:UP000001059};
RN   [1] {ECO:0000313|EMBL:ADE36016.1, ECO:0000313|Proteomes:UP000001059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35705 / DSM 5219 / SLP
RC   {ECO:0000313|Proteomes:UP000001059};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Lykidis A., Saunders E., Brettin T., Detter J.C., Han C., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Spring S., Schneider S., Schroeder M., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Methanohalophilus mahii DSM 5219.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC       forming a ternary complex with GTP and initiator tRNA.
CC       {ECO:0000256|HAMAP-Rule:MF_00119}.
CC   -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC       {ECO:0000256|HAMAP-Rule:MF_00119}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. EIF2G subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00119}.
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DR   EMBL; CP001994; ADE36016.1; -; Genomic_DNA.
DR   RefSeq; WP_013036959.1; NC_014002.1.
DR   EnsemblBacteria; ADE36016; ADE36016; Mmah_0488.
DR   GeneID; 8982629; -.
DR   KEGG; mmh:Mmah_0488; -.
DR   eggNOG; arCOG01563; Archaea.
DR   eggNOG; COG5257; LUCA.
DR   HOGENOM; HOG000229292; -.
DR   KO; K03242; -.
DR   OMA; NIGMVGH; -.
DR   OrthoDB; 25592at2157; -.
DR   BioCyc; MMAH547558:G1GHT-489-MONOMER; -.
DR   Proteomes; UP000001059; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd15490; eIF2_gamma_III; 1.
DR   HAMAP; MF_00119; eIF_2_gamma; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; TF_GTP-bd_dom.
DR   InterPro; IPR022424; TIF2_gsu.
DR   InterPro; IPR015256; TIF2_gsu_C.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR   Pfam; PF09173; eIF2_C; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF50465; SSF50465; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03680; eif2g_arch; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5EA15.
DR   SWISS-2DPAGE; D5EA15.
KW   GTP-binding {ECO:0000256|HAMAP-Rule:MF_00119};
KW   Initiation factor {ECO:0000256|HAMAP-Rule:MF_00119,
KW   ECO:0000313|EMBL:ADE36016.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00119};
KW   Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00119};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001059}.
FT   DOMAIN          3..200
FT                   /note="Tr-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51722"
FT   NP_BIND         12..19
FT                   /note="GTP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00119"
FT   NP_BIND         87..91
FT                   /note="GTP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00119"
FT   NP_BIND         143..146
FT                   /note="GTP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00119"
SQ   SEQUENCE   408 AA;  43796 MW;  171F652E452D5404 CRC64;
     MSQPCVNIGM VGHVDHGKTT LVRSLSGVWT DKHSEELKRG ISIRLGYADT TLMKCPTCPE
     PRCYSVKKEC PHCGAKTEQV RTISFVDSPG HETLMATMLS GAAIMDGAIL VIAANEECPQ
     PQTKEHLMAL DIIGIKNVVI VQNKIDLVNR KDVIENYKQI KDFVKGTVAE NAPIIPISAQ
     QDINIDALIG AMEKVIPAPT YKLDKEARML IARSFDINRP GLPIDQISGG VIGGTLTEGT
     LKAGDDLEIK PGRKVESEGA IHWDPIHTRV TGIIAGTTPV DEATPGGLLA VGTELDPDLT
     KSDSLTGQVA GKPGTLPSTN HSFTLRLKLL DRVVGVDDEG EIGQIKTSEP LMLNAGTATT
     VGIVTSARED VAEVNLKRPV CADIGSMVAI SRRIGSRWRL IGIRVIED
//

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