(data stored in SCRATCH zone)

SWISSPROT: D5UPA9_TSUPD

ID   D5UPA9_TSUPD            Unreviewed;       531 AA.
AC   D5UPA9;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   08-MAY-2019, entry version 49.
DE   SubName: Full=Drug resistance transporter, EmrB/QacA subfamily {ECO:0000313|EMBL:ADG76661.1};
GN   OrderedLocusNames=Tpau_0007 {ECO:0000313|EMBL:ADG76661.1};
OS   Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 /
OS   NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum).
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG76661.1, ECO:0000313|Proteomes:UP000001213};
RN   [1] {ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Munk A.C., Brettin T., Detter J.C.,
RA   Tapia R., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADG76661.1, ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RX   PubMed=21886861;
RA   Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA   Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Tapia R., Han C., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Yasawong M., Brambilla E.M., Rohde M.,
RA   Sikorski J., Goker M., Detter J.C., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Tsukamurella paurometabola type strain
RT   (no. 33).";
RL   Stand. Genomic Sci. 4:342-351(2011).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; CP001966; ADG76661.1; -; Genomic_DNA.
DR   RefSeq; WP_013124716.1; NC_014158.1.
DR   STRING; 521096.Tpau_0007; -.
DR   EnsemblBacteria; ADG76661; ADG76661; Tpau_0007.
DR   KEGG; tpr:Tpau_0007; -.
DR   eggNOG; ENOG4105C57; Bacteria.
DR   eggNOG; COG0477; LUCA.
DR   HOGENOM; HOG000239124; -.
DR   OMA; CWIACAL; -.
DR   OrthoDB; 1108236at2; -.
DR   BioCyc; TPAU521096:G1GKO-7-MONOMER; -.
DR   Proteomes; UP000001213; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 2.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5UPA9.
DR   SWISS-2DPAGE; D5UPA9.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001213};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001213};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM     14     39       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     51     70       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     82     99       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    111    132       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    144    163       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    169    190       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    202    222       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    228    251       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    272    295       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    307    328       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    335    354       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    360    378       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    408    427       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    483    502       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       16    506       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   531 AA;  55032 MW;  1167BC2176FF63A8 CRC64;
     MSASSGALSA PKRWISLATV CIAVLMTGMD NSIVTIALPT LSNEFGGGMS ALQWIVDSYT
     LVFAGLLLAT GYFGDRIGRR KVLVAGLVCF IVISVLATRS TSLAQLITAR AALGAAAALI
     FPATLAIISV LFPEKQERTK AIAVWSAAAG ASIAIGPVVG GYLVEHFAWS SVFWINVPIS
     VIAIIGCLTL VPESFGSERP SFDLFGVLLS ISGITLLVWA LIEAPNFGWG SAPVVGALVA
     AAVFLVTFVV YERRQANPVL DVTLFRSRGF AMGSFAICAG FFCLLGFVFI TIMYFQAVLG
     YGPLETAVRV IPFALVAVAV TPLAALANTE RRMRFAISTG LAIMAAGFVF TSRLTESADY
     LTQILPSMSV IAVGLGLLQG PATTSVMTSV PSGEAGAGSA VNDTTREVGG ALGVAILGSV
     VAHLYSARVA EDVARLPVAP GIRAEAESSV IGGVRAIGAA PPELQAALGH TVQQAFVSAM
     QSANLVAAGV GAVACVVVAV FLRTRPEARH RRSTSQTQVS VHDLVGRRAG E
//

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