(data stored in SCRATCH zone)

SWISSPROT: D5UPY4_TSUPD

ID   D5UPY4_TSUPD            Unreviewed;       450 AA.
AC   D5UPY4;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=Integral membrane sensor signal transduction histidine kinase {ECO:0000313|EMBL:ADG76752.1};
GN   OrderedLocusNames=Tpau_0098 {ECO:0000313|EMBL:ADG76752.1};
OS   Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 /
OS   NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum).
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG76752.1, ECO:0000313|Proteomes:UP000001213};
RN   [1] {ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Munk A.C., Brettin T., Detter J.C.,
RA   Tapia R., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADG76752.1, ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RX   PubMed=21886861;
RA   Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA   Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Tapia R., Han C., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Yasawong M., Brambilla E.M., Rohde M.,
RA   Sikorski J., Goker M., Detter J.C., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Tsukamurella paurometabola type strain
RT   (no. 33).";
RL   Stand. Genomic Sci. 4:342-351(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; CP001966; ADG76752.1; -; Genomic_DNA.
DR   RefSeq; WP_013124807.1; NC_014158.1.
DR   STRING; 521096.Tpau_0098; -.
DR   EnsemblBacteria; ADG76752; ADG76752; Tpau_0098.
DR   KEGG; tpr:Tpau_0098; -.
DR   eggNOG; ENOG41065SU; Bacteria.
DR   eggNOG; COG0642; LUCA.
DR   HOGENOM; HOG000223177; -.
DR   KO; K07654; -.
DR   OMA; MEVTRFD; -.
DR   OrthoDB; 1827824at2; -.
DR   BioCyc; TPAU521096:G1GKO-99-MONOMER; -.
DR   Proteomes; UP000001213; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; D5UPY4.
DR   SWISS-2DPAGE; D5UPY4.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001213};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:ADG76752.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001213};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    450       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003077614.
FT   TRANSMEM    142    165       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      166    218       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      233    450       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   450 AA;  48308 MW;  B08A84D6AB7E39B3 CRC64;
     MAGSLRARLL VIIVLVTSFT AAVTGASVAY VVRDWVYEDA QQAVLTAFRH DMERFDDQPT
     MENLLGDYLV TTSDGGVVQP GTVPPGTVPS SMSADLRATP SIYRFQRLAD GRLLVGHSSS
     KHPYLIYSVQ PLEGVQQRLR QLMTFVALAT LGGALLGGLA GVLVARAVTR PLRRVQDVAS
     AVAAGDSTAR LPETSLAELR ELSVNFNGML DRQNESLDVL RRQDERSRRF ASDVSHELRS
     PLAALVPAAE VLREEADAMA AESSGHPDLA RAARMVASEV DGLAQLLDDL LEITRLDAGV
     AQVRAEEFDL VATVREALDA RGWSGVRIDG PGELWVNADR RRVVAVVTNL VGNALRHGAP
     PVTVSMHRWA QQGDGGAVVE VRDHGGGVPE GHEDLIFDRL HKAQAARSRG AGGGAGLGLA
     IARDNARLLG GDVDYRRDGA TTVFRAWFRG
//

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