(data stored in SCRATCH zone)

SWISSPROT: D5URD1_TSUPD

ID   D5URD1_TSUPD            Unreviewed;       403 AA.
AC   D5URD1;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   08-MAY-2019, entry version 46.
DE   SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:ADG76984.1};
DE            EC=2.3.1.16 {ECO:0000313|EMBL:ADG76984.1};
GN   OrderedLocusNames=Tpau_0341 {ECO:0000313|EMBL:ADG76984.1};
OS   Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 /
OS   NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum).
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG76984.1, ECO:0000313|Proteomes:UP000001213};
RN   [1] {ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Munk A.C., Brettin T., Detter J.C.,
RA   Tapia R., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADG76984.1, ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RX   PubMed=21886861;
RA   Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA   Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Tapia R., Han C., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Yasawong M., Brambilla E.M., Rohde M.,
RA   Sikorski J., Goker M., Detter J.C., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Tsukamurella paurometabola type strain
RT   (no. 33).";
RL   Stand. Genomic Sci. 4:342-351(2011).
CC   -!- SIMILARITY: Belongs to the thiolase family.
CC       {ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; CP001966; ADG76984.1; -; Genomic_DNA.
DR   RefSeq; WP_013125030.1; NC_014158.1.
DR   STRING; 521096.Tpau_0341; -.
DR   EnsemblBacteria; ADG76984; ADG76984; Tpau_0341.
DR   KEGG; tpr:Tpau_0341; -.
DR   eggNOG; ENOG4105CHU; Bacteria.
DR   eggNOG; COG0183; LUCA.
DR   HOGENOM; HOG000012239; -.
DR   KO; K00626; -.
DR   OMA; RIRSMAT; -.
DR   OrthoDB; 287662at2; -.
DR   BioCyc; TPAU521096:G1GKO-324-MONOMER; -.
DR   Proteomes; UP000001213; Chromosome.
DR   GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR01930; AcCoA-C-Actrans; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5URD1.
DR   SWISS-2DPAGE; D5URD1.
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:ADG76984.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001213};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001213};
KW   Transferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:ADG76984.1}.
FT   DOMAIN        5    229       Thiolase_N. {ECO:0000259|Pfam:PF00108}.
FT   DOMAIN      281    402       Thiolase_C. {ECO:0000259|Pfam:PF02803}.
FT   ACT_SITE     91     91       Acyl-thioester intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR000429-1}.
FT   ACT_SITE    359    359       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
FT   ACT_SITE    389    389       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
SQ   SEQUENCE   403 AA;  41990 MW;  6A3A92E499D007D0 CRC64;
     MSDAFIYEAI RTPRGKLKGG SLTAIKPTDL VVGLIDEIKD RNPDLDPAAV DDIVLGVVSP
     VGEQGADIAR TASIVAGLPD TVAGVQINRF CASGLEATNM AAQKVGSALG DDLVLAGGVE
     SMSRVPMGSD FGALFYDPQY SYDNYIAPQG IGADLIATIE GFSRDDVDQY SAQSQELAAK
     AWDEGRFAKS VVPVKDQNGL VVLDNDEHRR PGTTAADLGK LRPAFTVVGE MGGFDAVALQ
     KYTHVEKIDH VHTGGNSSGI VDGAALVLVG NEAGGKKAGL TPRGRIVATA STGADPTIML
     TGPTPATEKV LAKAGLTKDD IDVWELNEAF ASVVLKWMKD FKLDREQVNV NGGAIALGHP
     LGATGAMLVG TVLDELERTG GRYGLITLCI AGGMGSATII ERI
//

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