(data stored in SCRATCH zone)

SWISSPROT: D5US23_TSUPD

ID   D5US23_TSUPD            Unreviewed;       485 AA.
AC   D5US23;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   RecName: Full=Catalase {ECO:0000256|RuleBase:RU000498};
DE            EC=1.11.1.6 {ECO:0000256|RuleBase:RU000498};
GN   OrderedLocusNames=Tpau_0449 {ECO:0000313|EMBL:ADG77090.1};
OS   Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 /
OS   NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum).
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG77090.1, ECO:0000313|Proteomes:UP000001213};
RN   [1] {ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Munk A.C., Brettin T., Detter J.C.,
RA   Tapia R., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADG77090.1, ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RX   PubMed=21886861;
RA   Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA   Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Tapia R., Han C., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Yasawong M., Brambilla E.M., Rohde M.,
RA   Sikorski J., Goker M., Detter J.C., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Tsukamurella paurometabola type strain
RT   (no. 33).";
RL   Stand. Genomic Sci. 4:342-351(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240;
CC         EC=1.11.1.6; Evidence={ECO:0000256|RuleBase:RU000498};
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|PIRSR:PIRSR038928-2};
CC   -!- SIMILARITY: Belongs to the catalase family.
CC       {ECO:0000256|RuleBase:RU000498}.
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DR   EMBL; CP001966; ADG77090.1; -; Genomic_DNA.
DR   RefSeq; WP_013125132.1; NC_014158.1.
DR   STRING; 521096.Tpau_0449; -.
DR   EnsemblBacteria; ADG77090; ADG77090; Tpau_0449.
DR   KEGG; tpr:Tpau_0449; -.
DR   eggNOG; ENOG4105CH6; Bacteria.
DR   eggNOG; COG0753; LUCA.
DR   HOGENOM; HOG000087852; -.
DR   KO; K03781; -.
DR   OMA; HADFGRM; -.
DR   OrthoDB; 1584770at2; -.
DR   BioCyc; TPAU521096:G1GKO-431-MONOMER; -.
DR   Proteomes; UP000001213; Chromosome.
DR   GO; GO:0004096; F:catalase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd08156; catalase_clade_3; 1.
DR   Gene3D; 2.40.180.10; -; 1.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR040333; Catalase_3.
DR   InterPro; IPR024708; Catalase_AS.
DR   InterPro; IPR024711; Catalase_clade1/3.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR037060; Catalase_core_sf.
DR   InterPro; IPR002226; Catalase_haem_BS.
DR   InterPro; IPR010582; Catalase_immune_responsive.
DR   InterPro; IPR020835; Catalase_sf.
DR   PANTHER; PTHR11465; PTHR11465; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   Pfam; PF06628; Catalase-rel; 1.
DR   PIRSF; PIRSF038928; Catalase_clade1-3; 1.
DR   PRINTS; PR00067; CATALASE.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF56634; SSF56634; 1.
DR   PROSITE; PS00437; CATALASE_1; 1.
DR   PROSITE; PS00438; CATALASE_2; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5US23.
DR   SWISS-2DPAGE; D5US23.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001213};
KW   Heme {ECO:0000256|PIRSR:PIRSR038928-2, ECO:0000256|RuleBase:RU000498};
KW   Hydrogen peroxide {ECO:0000256|RuleBase:RU000498};
KW   Iron {ECO:0000256|PIRSR:PIRSR038928-2, ECO:0000256|RuleBase:RU000498};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR038928-2,
KW   ECO:0000256|RuleBase:RU000498};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000498,
KW   ECO:0000313|EMBL:ADG77090.1};
KW   Peroxidase {ECO:0000256|RuleBase:RU000498,
KW   ECO:0000313|EMBL:ADG77090.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001213}.
FT   DOMAIN        9    390       Catalase. {ECO:0000259|SMART:SM01060}.
FT   ACT_SITE     56     56       {ECO:0000256|PIRSR:PIRSR038928-1}.
FT   ACT_SITE    128    128       {ECO:0000256|PIRSR:PIRSR038928-1}.
FT   METAL       338    338       Iron (heme axial ligand).
FT                                {ECO:0000256|PIRSR:PIRSR038928-2}.
SQ   SEQUENCE   485 AA;  54519 MW;  D5AE53C79F65A1BA CRC64;
     MTDHRNYTTT DSGAPAGSDQ HSLTVGAGGP IVLHDHYLIE QMAQFNRERI PERQPHAKGS
     GAFGTFETTA DVSDYTCAAL FQPGVTTDMV ARFSTVAGER GSADTWRDPR GFALKFYTDE
     GVYDLVGNNT PVFFIKDPLK FQHFIRSQKR RADNNLRDHD MQWDFWTLSP ESSHQVTWLM
     GDRGIPKSWR HMNGYGSHTY LWVNDAGVKH WVKYHFISDQ GIDYLTQDEA DRLAGADGDY
     HVRDLFEAIR DGEHPSWTLK VQIMPFEDAA TYRYNPFDLT KVWPHSDYPL VEVGTMTLHT
     NPTDNHAQIE QAAFEPNNLV PGIGLSPDRM LLGRVFAYAD AHRARLGANY KQIPVNAPRN
     EVRSYSKDGA MRIDPVRDPV YAPNSKGGPS ADYPGQAEPQ WAADGEIVRT AYVDHAEDDD
     VSQPRTLIRE VMDEAARERL VDNVAGHLLD GVSPPVLQRA FEYWTNIDPE IGGRIERAVA
     EAGTD
//

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