(data stored in SCRATCH zone)

SWISSPROT: D5US68_TSUPD

ID   D5US68_TSUPD            Unreviewed;       846 AA.
AC   D5US68;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   08-MAY-2019, entry version 67.
DE   RecName: Full=Chaperone protein ClpB {ECO:0000256|RuleBase:RU362034};
GN   Name=clpB {ECO:0000256|RuleBase:RU362034};
GN   OrderedLocusNames=Tpau_0494 {ECO:0000313|EMBL:ADG77135.1};
OS   Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 /
OS   NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum).
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG77135.1, ECO:0000313|Proteomes:UP000001213};
RN   [1] {ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Munk A.C., Brettin T., Detter J.C.,
RA   Tapia R., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADG77135.1, ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RX   PubMed=21886861;
RA   Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA   Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Tapia R., Han C., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Yasawong M., Brambilla E.M., Rohde M.,
RA   Sikorski J., Goker M., Detter J.C., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Tsukamurella paurometabola type strain
RT   (no. 33).";
RL   Stand. Genomic Sci. 4:342-351(2011).
CC   -!- FUNCTION: Part of a stress-induced multi-chaperone system, it is
CC       involved in the recovery of the cell from heat-induced damage, in
CC       cooperation with DnaK, DnaJ and GrpE.
CC       {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC       {ECO:0000256|SAAS:SAAS00721915}.
CC   -!- SUBUNIT: Homohexamer; The oligomerization is ATP-dependent.
CC       {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU362034,
CC       ECO:0000256|SAAS:SAAS00738470}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|RuleBase:RU004432, ECO:0000256|SAAS:SAAS01144294}.
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DR   EMBL; CP001966; ADG77135.1; -; Genomic_DNA.
DR   RefSeq; WP_013125177.1; NC_014158.1.
DR   STRING; 521096.Tpau_0494; -.
DR   EnsemblBacteria; ADG77135; ADG77135; Tpau_0494.
DR   KEGG; tpr:Tpau_0494; -.
DR   eggNOG; ENOG4105C2Z; Bacteria.
DR   eggNOG; COG0542; LUCA.
DR   HOGENOM; HOG000218209; -.
DR   KO; K03695; -.
DR   OMA; HHKVRIK; -.
DR   OrthoDB; 44062at2; -.
DR   BioCyc; TPAU521096:G1GKO-477-MONOMER; -.
DR   Proteomes; UP000001213; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019538; P:protein metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0042026; P:protein refolding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009408; P:response to heat; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1780.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR017730; Chaperonin_ClpB.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR004176; Clp_N.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF81923; SSF81923; 1.
DR   TIGRFAMs; TIGR03346; chaperone_ClpB; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5US68.
DR   SWISS-2DPAGE; D5US68.
KW   ATP-binding {ECO:0000256|RuleBase:RU004432,
KW   ECO:0000256|SAAS:SAAS01144309};
KW   Chaperone {ECO:0000256|RuleBase:RU004432,
KW   ECO:0000256|SAAS:SAAS00127789};
KW   Coiled coil {ECO:0000256|RuleBase:RU362034};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001213};
KW   Cytoplasm {ECO:0000256|RuleBase:RU362034,
KW   ECO:0000256|SAAS:SAAS00738398};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU004432,
KW   ECO:0000256|SAAS:SAAS01144287};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001213};
KW   Repeat {ECO:0000256|SAAS:SAAS00983801};
KW   Stress response {ECO:0000256|RuleBase:RU362034}.
FT   DOMAIN      194    340       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      597    755       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      754    845       ClpB_D2-small. {ECO:0000259|SMART:
FT                                SM01086}.
FT   COILED      462    489       {ECO:0000256|RuleBase:RU362034}.
SQ   SEQUENCE   846 AA;  91873 MW;  7BD41799C3900FD8 CRC64;
     MDSFNPTTKT QAALTSALQA ASAAGNPEIS PAHLLVALLD QTDGIAAPLL KAVGVDPVTV
     RNRAQELVDR KPKASGSTTQ PQLSRESLAS ITAAQKLATE MGDQYVSTEH VLYGLSEAAQ
     VLGNAGATPQ AIQEAFTAVR GSAKVTSQDP EGQYQALEKY STDLTARARE GKLDPVIGRD
     NEIRRVVQVL SRRTKNNPVL IGEPGVGKTA IVEGLAQRVV TGDVPESLRG KTVISLDLGS
     MVAGAKYRGE FEERLKAVLD EIKASSGQII TFIDELHTIV GAGATGDSAM DAGNMIKPML
     ARGELRLVGA TTLDEYRQYI EKDAALERRF QQVLVGEPSV EDTIGILRGL KERYEVHHGV
     RITDSALVSA ASLSDRYITS RFLPDKAIDL VDEAASRLRM EIDSRPEEID AEERIVRRLE
     IEEMALSKET DAASVDRLEK LRGELADHKE KLAQLTSRWQ NEKGAIDSVR TLKEQLENLK
     GESDRAERDG DLGRAAELRY GQIPALEKEL DEAVAASGAA SDGEVMLKEE VGPDDVADVV
     SSWTGIPAGR MLEGETAKLL RMESEIGKRV IGQEAAVEAV SDAVRRTRAG VADPNRPTGS
     FLFLGPTGVG KTELAKGLAE FLFDDERAMV RIDMSEYGEK HSVARLVGAP PGYVGYEAGG
     QLTEAVRRRP YTVVLFDEVE KAHPDVFDVL LQVLDEGRLT DGQGRTVDFR NTILILTSNL
     GAGGDKDHVM NAVRAKFKPE FINRLDDVLI FDSLDSGQLT GIVDIQLDQL RKRLSQRRLD
     LQVSDEAKGW LAERGFDPLY GARPLRRLVQ QSIGDQLAKA LLAGDVRDGD PVKVTVSEDG
     DRLIIN
//

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