(data stored in SCRATCH zone)

SWISSPROT: D5USC3_TSUPD

ID   D5USC3_TSUPD            Unreviewed;      1062 AA.
AC   D5USC3;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   10-APR-2019, entry version 54.
DE   SubName: Full=tRNA-guanine transglycosylase, various specificities {ECO:0000313|EMBL:ADG77190.1};
DE            EC=2.4.2.29 {ECO:0000313|EMBL:ADG77190.1};
GN   OrderedLocusNames=Tpau_0550 {ECO:0000313|EMBL:ADG77190.1};
OS   Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 /
OS   NBRC 16120 / NCTC 13040) (Corynebacterium paurometabolum).
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=521096 {ECO:0000313|EMBL:ADG77190.1, ECO:0000313|Proteomes:UP000001213};
RN   [1] {ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Mikhailova N., Munk A.C., Brettin T., Detter J.C.,
RA   Tapia R., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Jando M., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Tsukamurella paurometabola DSM 20162.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADG77190.1, ECO:0000313|Proteomes:UP000001213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040
RC   {ECO:0000313|Proteomes:UP000001213};
RX   PubMed=21886861;
RA   Munk A.C., Lapidus A., Lucas S., Nolan M., Tice H., Cheng J.F.,
RA   Del Rio T.G., Goodwin L., Pitluck S., Liolios K., Huntemann M.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Tapia R., Han C., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Yasawong M., Brambilla E.M., Rohde M.,
RA   Sikorski J., Goker M., Detter J.C., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Tsukamurella paurometabola type strain
RT   (no. 33).";
RL   Stand. Genomic Sci. 4:342-351(2011).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; CP001966; ADG77190.1; -; Genomic_DNA.
DR   STRING; 521096.Tpau_0550; -.
DR   EnsemblBacteria; ADG77190; ADG77190; Tpau_0550.
DR   KEGG; tpr:Tpau_0550; -.
DR   eggNOG; ENOG4105C0R; Bacteria.
DR   eggNOG; ENOG410XNN3; LUCA.
DR   BioCyc; TPAU521096:G1GKO-533-MONOMER; -.
DR   Proteomes; UP000001213; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008479; F:queuine tRNA-ribosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006400; P:tRNA modification; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   Gene3D; 3.20.20.105; -; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001411; Tet-R_TetB/Drug-R_transptr.
DR   InterPro; IPR036511; TGT-like_sf.
DR   InterPro; IPR002616; tRNA_ribo_trans-like.
DR   PANTHER; PTHR23501; PTHR23501; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   Pfam; PF01702; TGT; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   SUPFAM; SSF51713; SSF51713; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   TIGRFAMs; TIGR00449; tgt_general; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; D5USC3.
DR   SWISS-2DPAGE; D5USC3.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001213};
KW   Glycosyltransferase {ECO:0000313|EMBL:ADG77190.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001213};
KW   Transferase {ECO:0000256|SAAS:SAAS00876991,
KW   ECO:0000313|EMBL:ADG77190.1};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM     27     52       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     64     83       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     95    114       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    120    141       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    153    175       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    187    209       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    221    240       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    246    269       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    289    312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    324    344       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    356    375       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    381    399       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    420    442       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    524    543       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       30    548       MFS. {ECO:0000259|PROSITE:PS50850}.
FT   COILED      641    661       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1062 AA;  111952 MW;  88CC0F2977569097 CRC64;
     MTATTLENQS PEQAAGVPSG PLTHKQILYI LAGLMTGMFL AALDQTIVST AIRTIADDLS
     GYQLQVWVTT AYLITSTIVT PLYGKLSDIY GRKPFFMFAI TVFVLGSLLC SFSTSMYELA
     AFRAVQGLGA GGLMSLALTI VGDIVPPRER ARYQGYFLAV FGTSSVLGPV LGGVFSGADS
     ILGITGWRWV FLVNVPIGVI ALLVVYRVLQ LPHTRREGVR IDWVGAFMLA VGIVPLLIVA
     EQGREWGWGS TKSITCYAVG AGGVLAFIII EKMMGEDAII PLRIFRNRIF AQGVLISVVV
     GAAMFGGISL LPQYFQVVRG ASPTVAGFMM LPMVLGLMMG SILAGQMISR TGRYRIYPII
     GAVLLTVGMW ALHYVTADVR LAAVMAGAAL IGFGLGNLMQ PLTLAMQNIL PPQDMGVSTA
     AATFFRQIGG TLGVAVFLSV LFSEMPKNMQ SRLTDAAADP DYTAALQRAA AGHDGQAAQE
     FANKLAARDS SAVSGIMSDT SALQKLPSTL VHPFKAGFAD SMDTVFLAVT VLSAIGLLLV
     LFWKSVPLRT APAMETIEEE VVGAVLAGGP VAEPEPAAAA DTAPVSPAPV GAHPPGTTGV
     GTASRAVARQ TRAPGPRTVE PVPPDDDRTA PVRVDPALAE IAELRSQNAE LAAELAELRT
     GYRAIAGHTR LRAVGASDPT GFRIEVQGPG AARTGTLSTP HGEIATPAYL PVAARGAVAG
     ITPEMLAALG VQAVTVDLHE LYLQPGTAMI EGAGGIGRAM AWAGPVLGDT GITAVAAAKK
     TRVTDEGIAF RSRLDGGAHR WDPEEAVRVA HRIGVDIAFA MADPVAATAP RAQLEAGVNR
     SQQWAARALV EHSWQTADRG DRQSLWAVVT GGADAGLRRA AARGLRRLSE QDVQSGGLGF
     GGYRIDGVRS AAAEALQLRA ATEELDRERP RHLATVATPA DLFAAIEAGI DLFDGTAAAE
     AGREGRVFTR DGVLDLTDPQ LRADFRPIDP GADRRGPANP ADEFTRAYVN HLFAANEGLA
     VTLCTLHNEH FFATLAADAR RALTDGRYPA FTESFLRRFA KV
//

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