(data stored in ACNUC9543 zone)

SWISSPROT: D6XG53_TRYB2

ID   D6XG53_TRYB2            Unreviewed;       735 AA.
AC   D6XG53;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   08-MAY-2019, entry version 58.
DE   SubName: Full=Pre-mRNA splicing factor ATP-dependent RNA helicase, putative {ECO:0000313|EMBL:AAZ11230.1};
GN   ORFNames=Tb927.5.1150 {ECO:0000313|EMBL:AAZ11230.1};
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431 {ECO:0000313|EMBL:AAZ11230.1, ECO:0000313|Proteomes:UP000008524};
RN   [1] {ECO:0000313|EMBL:AAZ11230.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ11230.1};
RX   PubMed=16020724; DOI=10.1126/science.1112181;
RA   El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA   Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA   Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA   Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA   Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA   Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA   Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J.,
RA   Salzberg S.L., Shallom J., Silva J.C., Sundaram J., Westenberger S.,
RA   White O., Melville S.E., Donelson J.E., Andersson B., Stuart K.D.,
RA   Hall N.;
RT   "Comparative genomics of trypanosomatid parasitic protozoa.";
RL   Science 309:404-409(2005).
RN   [2] {ECO:0000313|EMBL:AAZ11230.1, ECO:0000313|Proteomes:UP000008524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ11230.1,
RC   ECO:0000313|Proteomes:UP000008524};
RX   PubMed=16020726; DOI=10.1126/science.1112642;
RA   Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA   Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B.,
RA   Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L.,
RA   Wickstead B., Alsmark U.C.M., Arrowsmith C., Atkin R.J., Barron A.J.,
RA   Bringaud F., Brooks K., Carrington M., Cherevach I.,
RA   Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A.,
RA   Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C.,
RA   Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H.,
RA   Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K.,
RA   Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V.,
RA   Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M.,
RA   Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA   Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S.,
RA   Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A.,
RA   Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B.,
RA   White O., Whitehead S., Woodward J., Wortman J., Adams M.D.,
RA   Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H.,
RA   Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M.,
RA   Melville S.E., El-Sayed N.M.A.;
RT   "The genome of the African trypanosome Trypanosoma brucei.";
RL   Science 309:416-422(2005).
RN   [3] {ECO:0000313|EMBL:AAX70473.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX70473.1};
RA   Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA   Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J.,
RA   Johnson J., Jones K., Koo H.L., Larkin C., Pai G., Peterson J.,
RA   Khalak H.G., Salzberg S., Simpson A.J., Tallon L., Van Aken S.,
RA   Wanless D., White O., Wortman J., Fraser C.M., El-Sayed N.M.A.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AC159443; AAX70473.1; -; Genomic_DNA.
DR   EMBL; CP000068; AAZ11230.1; -; Genomic_DNA.
DR   RefSeq; XP_844789.1; XM_839696.1.
DR   SMR; D6XG53; -.
DR   STRING; 5691.AAZ11230; -.
DR   PaxDb; D6XG53; -.
DR   GeneDB; Tb927.5.1150:pep; -.
DR   GeneID; 3657222; -.
DR   KEGG; tbr:Tb927.5.1150; -.
DR   EuPathDB; TriTrypDB:Tb927.5.1150; -.
DR   HOGENOM; HOG000175261; -.
DR   KO; K12820; -.
DR   OMA; QWCVDFA; -.
DR   Proteomes; UP000008524; Chromosome 5.
DR   GO; GO:0005730; C:nucleolus; IDA:GeneDB.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0034459; F:ATP-dependent 3'-5' RNA helicase activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0008380; P:RNA splicing; IMP:GeneDB.
DR   CDD; cd00079; HELICc; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
DR   PRODOM; D6XG53.
DR   SWISS-2DPAGE; D6XG53.
KW   ATP-binding {ECO:0000256|SAAS:SAAS01176619};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008524};
KW   Helicase {ECO:0000313|EMBL:AAZ11230.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01176622};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS01176608};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008524}.
FT   DOMAIN       51    212       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      238    415       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
SQ   SEQUENCE   735 AA;  82927 MW;  C3BC137819C1D606 CRC64;
     MLSKRNREGS RGAMGCGEKN PYTGRVLSSR YHALRGVREK LPIFAAKQKI QRLISRYQTL
     LLVGETGSGK TTQVPQFVLE MNPEHAIACT QPRRVAAISV SERVAEELDV TLGEEVGYCI
     RFDDTSSDRT RLKYLTDGML LREAMGDPML QRYSVIILDE AHERTVHTDI LIGAVKDLLH
     RRPDLRVVVM SATLEERRFQ SYFPEAPLVH VSGRMYDVEV YNSRLPEANY LEASIRTAMQ
     IHLYEGPGDI LIFLTGEDEI EQAVERLRLG IPMAEHTNAD CHKGPVAVLP LYSALPPKEQ
     RKVFQAAPEG TRKIVVATNV AETSLTIDGV VFVIDSGFSK QKVYNPKLRV ESLLVTPISQ
     ASARQRCGRA GRTRPGKCFR LYTAKAFDTL LQQQTYPEIL RCNLGSVILH MKMMGIEDLV
     NFDFVEPPAP ETLMRALELL NYLGAINDDG DMTKFGRRVA DFPLEPEMAA MLLHSPEYGC
     SDDIARICAM MSVQSPFVTP RNDQRGCAMR CRDQFYHPTG DHLALLNVFN AFYEGSNQSG
     SWASENYLNP RVMKQSVSIY RQLIGIMRRL NLSICSTYSA AQWGGAGDGE SDEYANEVRR
     AVLRGYFTKV ALSLPTKNQF LTLKDNVKCL LFPSTFLNRR PKFVVFNELV LTTNTYIRTV
     TSVSDEWLLE VNPLYFDPSE FEGVSRQVFE ELHRRNNRNN AAERDQNKDC LTGHKRRRGG
     DAPDNGDDDD DDDSS
//

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