(data stored in SCRATCH zone)

SWISSPROT: D6XXF9_BACIE

ID   D6XXF9_BACIE            Unreviewed;       213 AA.
AC   D6XXF9;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 54.
DE   RecName: Full=Futalosine hydrolase {ECO:0000256|HAMAP-Rule:MF_00991};
DE            Short=FL hydrolase {ECO:0000256|HAMAP-Rule:MF_00991};
DE            EC=3.2.2.26 {ECO:0000256|HAMAP-Rule:MF_00991};
DE   AltName: Full=Futalosine nucleosidase {ECO:0000256|HAMAP-Rule:MF_00991};
DE   AltName: Full=Menaquinone biosynthetic enzyme MqnB {ECO:0000256|HAMAP-Rule:MF_00991};
GN   Name=mqnB {ECO:0000256|HAMAP-Rule:MF_00991};
GN   OrderedLocusNames=Bsel_0478 {ECO:0000313|EMBL:ADH98016.1};
OS   Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS10).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Sporolactobacillaceae;
OC   unclassified Sporolactobacillaceae.
OX   NCBI_TaxID=439292 {ECO:0000313|EMBL:ADH98016.1, ECO:0000313|Proteomes:UP000000271};
RN   [1] {ECO:0000313|EMBL:ADH98016.1, ECO:0000313|Proteomes:UP000000271}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700615 / DSM 15326 / MLS10
RC   {ECO:0000313|Proteomes:UP000000271};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ovchinnikova G., Stolz J.;
RT   "Complete sequence of Bacillus selenitireducens MLS10.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydrolysis of futalosine (FL) to
CC       dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the
CC       biosynthesis of menaquinone (MK, vitamin K2). {ECO:0000256|HAMAP-
CC       Rule:MF_00991}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=futalosine + H2O = dehypoxanthine futalosine +
CC         hypoxanthine; Xref=Rhea:RHEA:25904, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:17368, ChEBI:CHEBI:58863, ChEBI:CHEBI:58864;
CC         EC=3.2.2.26; Evidence={ECO:0000256|HAMAP-Rule:MF_00991};
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00991}.
CC   -!- SIMILARITY: Belongs to the PNP/UDP phosphorylase family.
CC       Futalosine hydrolase subfamily. {ECO:0000256|HAMAP-Rule:MF_00991}.
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DR   EMBL; CP001791; ADH98016.1; -; Genomic_DNA.
DR   RefSeq; WP_013171445.1; NC_014219.1.
DR   STRING; 439292.Bsel_0478; -.
DR   EnsemblBacteria; ADH98016; ADH98016; Bsel_0478.
DR   KEGG; bse:Bsel_0478; -.
DR   eggNOG; ENOG4108UIH; Bacteria.
DR   eggNOG; COG0775; LUCA.
DR   HOGENOM; HOG000019418; -.
DR   KO; K11783; -.
DR   OMA; EAMEGYG; -.
DR   OrthoDB; 1860206at2; -.
DR   BioCyc; BSEL439292:G1GLR-508-MONOMER; -.
DR   UniPathway; UPA00079; -.
DR   Proteomes; UP000000271; Chromosome.
DR   GO; GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds; IEA:UniProtKB-UniRule.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1580; -; 1.
DR   HAMAP; MF_00991; MqnB; 1.
DR   InterPro; IPR019963; FL_hydrolase_MqnB.
DR   InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   Pfam; PF01048; PNP_UDP_1; 1.
DR   SUPFAM; SSF53167; SSF53167; 1.
DR   TIGRFAMs; TIGR03664; fut_nucase; 1.
PE   3: Inferred from homology;
DR   PRODOM; D6XXF9.
DR   SWISS-2DPAGE; D6XXF9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000271};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00991};
KW   Menaquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_00991};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000271}.
FT   DOMAIN       30    198       PNP_UDP_1. {ECO:0000259|Pfam:PF01048}.
SQ   SEQUENCE   213 AA;  22265 MW;  6A7E53EB04B693AC CRC64;
     MKQILIVTSV DKERQAVEAG LKGDPRFLTG LCGVGPVEAA VRTMKLLSTC SSSVEAVLNL
     GVAGGIPGKA AVGEAVLGTK TVQADLGFEQ ADGSFEAIEA LGFTVSERDA NSDLISRVRE
     ALRENVHEGP IVTQSTVTGT KASLETLLQR VPDAMAEGME GFAVHSAAEA YGIPALELRA
     ISNPVGPRKR GEWQLEDALH TLTGLTVQLK GGM
//

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