(data stored in SCRATCH zone)

SWISSPROT: D6ZAX9_SEGRD

ID   D6ZAX9_SEGRD            Unreviewed;       554 AA.
AC   D6ZAX9;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   16-JAN-2019, entry version 51.
DE   SubName: Full=Pyruvate decarboxylase {ECO:0000313|EMBL:ADG96738.1};
DE            EC=4.1.1.1 {ECO:0000313|EMBL:ADG96738.1};
GN   OrderedLocusNames=Srot_0251 {ECO:0000313|EMBL:ADG96738.1};
OS   Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 /
OS   DSM 44985 / JCM 13578).
OC   Bacteria; Actinobacteria; Corynebacteriales; Segniliparaceae;
OC   Segniliparus.
OX   NCBI_TaxID=640132 {ECO:0000313|EMBL:ADG96738.1, ECO:0000313|Proteomes:UP000002247};
RN   [1] {ECO:0000313|EMBL:ADG96738.1, ECO:0000313|Proteomes:UP000002247}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578
RC   {ECO:0000313|Proteomes:UP000002247};
RX   PubMed=21304703; DOI=10.4056/sigs.791633;
RA   Sikorski J., Lapidus A., Copeland A., Misra M., Glavina Del Rio T.,
RA   Nolan M., Lucas S., Chen F., Tice H., Cheng J.F., Jando M.,
RA   Schneider S., Bruce D., Goodwin L., Pitluck S., Liolios K.,
RA   Mikhailova N., Pati A., Ivanova N., Mavromatis K., Chen A.,
RA   Palaniappan K., Chertkov O., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Detter J.C., Han C., Rohde M., Goker M.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P.;
RT   "Complete genome sequence of Segniliparus rotundus type strain (CDC
RT   1076).";
RL   Stand. Genomic Sci. 2:203-211(2010).
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; CP001958; ADG96738.1; -; Genomic_DNA.
DR   RefSeq; WP_013137194.1; NC_014168.1.
DR   STRING; 640132.Srot_0251; -.
DR   EnsemblBacteria; ADG96738; ADG96738; Srot_0251.
DR   KEGG; srt:Srot_0251; -.
DR   eggNOG; ENOG4107RA9; Bacteria.
DR   eggNOG; COG3961; LUCA.
DR   HOGENOM; HOG000061334; -.
DR   KO; K21431; -.
DR   OMA; EWIGNCN; -.
DR   OrthoDB; 391134at2; -.
DR   BioCyc; SROT640132:G1GLH-253-MONOMER; -.
DR   Proteomes; UP000002247; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0004737; F:pyruvate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR012110; TPP_enzyme.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   PIRSF; PIRSF036565; Pyruvt_ip_decrb; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
DR   PRODOM; D6ZAX9.
DR   SWISS-2DPAGE; D6ZAX9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002247};
KW   Lyase {ECO:0000313|EMBL:ADG96738.1};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR036565-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR036565-2};
KW   Pyruvate {ECO:0000313|EMBL:ADG96738.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002247};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN        6    176       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      199    306       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      397    528       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
FT   METAL       435    435       Magnesium. {ECO:0000256|PIRSR:
FT                                PIRSR036565-2}.
FT   METAL       462    462       Magnesium. {ECO:0000256|PIRSR:
FT                                PIRSR036565-2}.
FT   METAL       464    464       Magnesium; via carbonyl oxygen.
FT                                {ECO:0000256|PIRSR:PIRSR036565-2}.
SQ   SEQUENCE   554 AA;  58577 MW;  4861B009D173F928 CRC64;
     MPQPYTIGHY LADRLAELGV RHVFGVPGDF NLMFLDRIVE HPGLAWVGNV NELNAGYAAD
     GYARMNGIAA LVTTFGVGEL SAVNATAGSY AEHVPVVHIC GGPTVDAQRA RRSLHHSLGD
     GDFEHFLRIQ REITCAQASL TPANATREID RVLREVREQR RPGYLLLPSD VAQVPSYPPA
     APIPGPQDAS SPGALAAFQE AAAKLLADKR PAVLADLLVH RFGAVGELAR LLDAGALPHA
     TLLWGKSIVD ELDPNFLGIY IGANSEPHVR AGVEEAEALI LAGVQFTDFI SGFFTQHLDV
     AKTVDIGPHE STVAGELFAP LEMRDALGAL TELLSGRPRP PEPAAPAPPA ASAASPGEAL
     TQASMWDLLA GAVTPGNIVI AEAGTSFFGL ATHPLPAGVT FIGQPLWASI GYTLPAALGA
     GLACPDRRVV LLIGDGSAQL TAQELSVIAR YGLNAVIVVV DNDGYTVERA IHGAQQPYND
     IDHWDYAKLL SAFEPETEPL CLRVGTVGGL RAAIEETEAA KDRLVLIEAV VAKMDMPPLL
     QKLGETMSEA NTRA
//

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