(data stored in SCRATCH zone)

SWISSPROT: D6ZC16_SEGRD

ID   D6ZC16_SEGRD            Unreviewed;       184 AA.
AC   D6ZC16;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 50.
DE   RecName: Full=5-formyltetrahydrofolate cyclo-ligase {ECO:0000256|RuleBase:RU361279};
DE            EC=6.3.3.2 {ECO:0000256|RuleBase:RU361279};
GN   OrderedLocusNames=Srot_0509 {ECO:0000313|EMBL:ADG96993.1};
OS   Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 /
OS   DSM 44985 / JCM 13578).
OC   Bacteria; Actinobacteria; Corynebacteriales; Segniliparaceae;
OC   Segniliparus.
OX   NCBI_TaxID=640132 {ECO:0000313|EMBL:ADG96993.1, ECO:0000313|Proteomes:UP000002247};
RN   [1] {ECO:0000313|EMBL:ADG96993.1, ECO:0000313|Proteomes:UP000002247}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578
RC   {ECO:0000313|Proteomes:UP000002247};
RX   PubMed=21304703; DOI=10.4056/sigs.791633;
RA   Sikorski J., Lapidus A., Copeland A., Misra M., Glavina Del Rio T.,
RA   Nolan M., Lucas S., Chen F., Tice H., Cheng J.F., Jando M.,
RA   Schneider S., Bruce D., Goodwin L., Pitluck S., Liolios K.,
RA   Mikhailova N., Pati A., Ivanova N., Mavromatis K., Chen A.,
RA   Palaniappan K., Chertkov O., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Detter J.C., Han C., Rohde M., Goker M.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P.;
RT   "Complete genome sequence of Segniliparus rotundus type strain (CDC
RT   1076).";
RL   Stand. Genomic Sci. 2:203-211(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-formyltetrahydrofolate + ATP = 5,10-
CC         methenyltetrahydrofolate + ADP + phosphate;
CC         Xref=Rhea:RHEA:10488, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57455, ChEBI:CHEBI:57457, ChEBI:CHEBI:456216;
CC         EC=6.3.3.2; Evidence={ECO:0000256|RuleBase:RU361279};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU361279};
CC   -!- SIMILARITY: Belongs to the 5-formyltetrahydrofolate cyclo-ligase
CC       family. {ECO:0000256|RuleBase:RU361279}.
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DR   EMBL; CP001958; ADG96993.1; -; Genomic_DNA.
DR   RefSeq; WP_013137449.1; NC_014168.1.
DR   STRING; 640132.Srot_0509; -.
DR   EnsemblBacteria; ADG96993; ADG96993; Srot_0509.
DR   KEGG; srt:Srot_0509; -.
DR   eggNOG; ENOG4107ZTI; Bacteria.
DR   eggNOG; COG0212; LUCA.
DR   HOGENOM; HOG000007299; -.
DR   OMA; ARTNMDE; -.
DR   OrthoDB; 1816478at2; -.
DR   BioCyc; SROT640132:G1GLH-512-MONOMER; -.
DR   Proteomes; UP000002247; Chromosome.
DR   GO; GO:0030272; F:5-formyltetrahydrofolate cyclo-ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.10420; -; 1.
DR   InterPro; IPR002698; FTHF_cligase.
DR   InterPro; IPR024185; FTHF_cligase-like_sf.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR23407:SF1; PTHR23407:SF1; 1.
DR   Pfam; PF01812; 5-FTHF_cyc-lig; 1.
DR   PIRSF; PIRSF006806; FTHF_cligase; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR02727; MTHFS_bact; 1.
PE   3: Inferred from homology;
DR   PRODOM; D6ZC16.
DR   SWISS-2DPAGE; D6ZC16.
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR006806-1,
KW   ECO:0000256|RuleBase:RU361279};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002247};
KW   Ligase {ECO:0000313|EMBL:ADG96993.1};
KW   Magnesium {ECO:0000256|RuleBase:RU361279};
KW   Metal-binding {ECO:0000256|RuleBase:RU361279};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR006806-1,
KW   ECO:0000256|RuleBase:RU361279};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002247}.
FT   NP_BIND      10     14       ATP. {ECO:0000256|PIRSR:PIRSR006806-1}.
FT   NP_BIND     127    135       ATP. {ECO:0000256|PIRSR:PIRSR006806-1}.
FT   BINDING      57     57       Substrate; via carbonyl oxygen.
FT                                {ECO:0000256|PIRSR:PIRSR006806-1}.
FT   BINDING      62     62       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR006806-1}.
SQ   SEQUENCE   184 AA;  19328 MW;  28833996311E3B91 CRC64;
     MGPQSSAQRK AALRAQTRSA RRALSDAQRA ARDRAVDAQA ARIAERFGPG DVVSSYVPTS
     LEPGSDRMLA AFADRGASVL VPVVVGVDAA LAWRHWPEEG QDAPPGALAE AAVVLVPALA
     VDRRGVRLGQ GGGHYDRSLA EAGPGAMLVA VVDDRELVDE LPCEPHDELL GWALTPKGLW
     RLGG
//

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