(data stored in SCRATCH zone)

SWISSPROT: D6ZCK4_SEGRD

ID   D6ZCK4_SEGRD            Unreviewed;      1025 AA.
AC   D6ZCK4;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 50.
DE   SubName: Full=UvrD/REP helicase {ECO:0000313|EMBL:ADG97046.1};
GN   OrderedLocusNames=Srot_0564 {ECO:0000313|EMBL:ADG97046.1};
OS   Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 /
OS   DSM 44985 / JCM 13578).
OC   Bacteria; Actinobacteria; Corynebacteriales; Segniliparaceae;
OC   Segniliparus.
OX   NCBI_TaxID=640132 {ECO:0000313|EMBL:ADG97046.1, ECO:0000313|Proteomes:UP000002247};
RN   [1] {ECO:0000313|EMBL:ADG97046.1, ECO:0000313|Proteomes:UP000002247}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578
RC   {ECO:0000313|Proteomes:UP000002247};
RX   PubMed=21304703; DOI=10.4056/sigs.791633;
RA   Sikorski J., Lapidus A., Copeland A., Misra M., Glavina Del Rio T.,
RA   Nolan M., Lucas S., Chen F., Tice H., Cheng J.F., Jando M.,
RA   Schneider S., Bruce D., Goodwin L., Pitluck S., Liolios K.,
RA   Mikhailova N., Pati A., Ivanova N., Mavromatis K., Chen A.,
RA   Palaniappan K., Chertkov O., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Detter J.C., Han C., Rohde M., Goker M.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P.;
RT   "Complete genome sequence of Segniliparus rotundus type strain (CDC
RT   1076).";
RL   Stand. Genomic Sci. 2:203-211(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01129065};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS01099290};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|SAAS:SAAS00709641}.
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DR   EMBL; CP001958; ADG97046.1; -; Genomic_DNA.
DR   STRING; 640132.Srot_0564; -.
DR   EnsemblBacteria; ADG97046; ADG97046; Srot_0564.
DR   KEGG; srt:Srot_0564; -.
DR   eggNOG; ENOG4105F1I; Bacteria.
DR   eggNOG; COG0210; LUCA.
DR   eggNOG; COG2887; LUCA.
DR   HOGENOM; HOG000247970; -.
DR   OMA; GVQEGLW; -.
DR   Proteomes; UP000002247; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.90.320.10; -; 1.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR011604; Exonuc_phg/RecB_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR034739; UvrD/AddA_N.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
DR   PRODOM; D6ZCK4.
DR   SWISS-2DPAGE; D6ZCK4.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00146071};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002247};
KW   DNA damage {ECO:0000256|SAAS:SAAS01099294};
KW   DNA repair {ECO:0000256|SAAS:SAAS01099287};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00745286};
KW   Exonuclease {ECO:0000256|SAAS:SAAS01033115};
KW   Helicase {ECO:0000256|SAAS:SAAS00553650, ECO:0000313|EMBL:ADG97046.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00146062};
KW   Nuclease {ECO:0000256|SAAS:SAAS01033141};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00145996};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002247}.
FT   DOMAIN       11    328       UvrD-like helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51198}.
FT   DOMAIN      310    591       UvrD-like helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51217}.
SQ   SEQUENCE   1025 AA;  108311 MW;  20DE5CD4D6D804E1 CRC64;
     MDRMSPRQLF EEPARLFQDL ASGRRGPFMV RGGPGSGKTR LVVDLACHWA PQPGTVTVVL
     TSNRAAADRL RAQIHGRLLR ASPQLALAKP LVRTTHSYAF ALLEARARAS GNPPPRLIPA
     AEQDATLREL AIDQAARWPE PLRAALGSME FTAQLRSVFQ RAAQHGHGPE GLIALGTARA
     RPEWVAAGRT WREYEQVMTL RGAVGMADPA ASPGALDAAE LLGAALDAVA EDPDLLLHPL
     GKPGSRFVVF VDDAQHFDPQ AARLSSLAAR RADLAVCTVD PDQSVFWFQG AQTGPGLWRE
     AEQLRLGPSQ RLSSSVAQLV AAVAPRSAPQ VATCRESAGE AQTRLYPTVA AQAEGVVEAL
     CRAHARDQVP WSRMAVLVRS VPVLEPSLAR AAALADVPLR LAAMSGPLAA NTAVSALLSL
     LKALARKALE PATALELLVS PIAGASVAQA RSLRRLLRAQ EPDRPSLDLL AELVLGAREH
     DVPEPVLRLR RVWRAACEAL GAPAPTVETV LWAAWSASGL EERLPEGDFA AVRALFAAAR
     AQRAADAADA AAELARFAER VERERLPVSA TLGDGGGSDA VTLLSAHAAA GQEWDVVVVC
     GVQEGLWPGF SESSSLLGVD ELAAALAGTP AEAKLDARKQ VLAQERRLLY LACSRAREQL
     LVTAVEGEGD LVPSRFLAPL APLALRTQEH GPAERAAAAP PPAPATPWSS AGVVAELRAL
     ACGADQHRAQ RAAAALAALA QAGVIGAHPK SWHGLAEVST SEPLAKDGSL TLSPSRVQQL
     LDCPLRWLFE RAMPAAPGEA AAIGTAVHLL ASVADRFPED ELQAALDAAA RAADERSARP
     PWAAQRRREQ LARLFAAFMA WRNASRGELT QVGVEIPVEM SVSGVTLRGR IDRLERTARG
     ELVIVDLKTA ATPRSAASVR EDPQLACYQL VVRMARDEPV AGGKLVYLGA LRQETGAAER
     EQPALTEEEA AQWNSTIREA AAAAAGPQFR ARPNQHCGSC PGRRCCPALQ SAPGAPLAGA
     AGGAR
//

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