(data stored in SCRATCH zone)

SWISSPROT: D7A007_STAND

ID   D7A007_STAND            Unreviewed;       354 AA.
AC   D7A007;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 54.
DE   RecName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000256|RuleBase:RU004473};
DE            EC=4.2.1.46 {ECO:0000256|RuleBase:RU004473};
GN   OrderedLocusNames=Snov_0084 {ECO:0000313|EMBL:ADH87421.1};
OS   Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 /
OS   NBRC 12443 / NCIB 9113).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Xanthobacteraceae; Starkeya.
OX   NCBI_TaxID=639283 {ECO:0000313|EMBL:ADH87421.1, ECO:0000313|Proteomes:UP000006633};
RN   [1] {ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Brettin T., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Beatson S., Kappler U.,
RA   Woyke T.;
RT   "Complete sequence of Starkeya novella DSM 506.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADH87421.1, ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RX   PubMed=23450099; DOI=10.4056/sigs.3006378;
RA   Kappler U., Davenport K., Beatson S., Lucas S., Lapidus A.,
RA   Copeland A., Berry K.W., Glavina Del Rio T., Hammon N., Dalin E.,
RA   Tice H., Pitluck S., Richardson P., Bruce D., Goodwin L.A., Han C.,
RA   Tapia R., Detter J.C., Chang Y.J., Jeffries C.D., Land M., Hauser L.,
RA   Kyrpides N.C., Goker M., Ivanova N., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of the facultatively chemolithoautotrophic
RT   and methylotrophic alpha Proteobacterium Starkeya novella type strain
RT   (ATCC 8093(T)).";
RL   Stand. Genomic Sci. 7:44-58(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-
CC         glucose + H2O; Xref=Rhea:RHEA:17221, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:57477, ChEBI:CHEBI:57649; EC=4.2.1.46;
CC         Evidence={ECO:0000256|RuleBase:RU004473};
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|RuleBase:RU004473};
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. dTDP-glucose dehydratase subfamily.
CC       {ECO:0000256|RuleBase:RU004473}.
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DR   EMBL; CP002026; ADH87421.1; -; Genomic_DNA.
DR   RefSeq; WP_013164926.1; NC_014217.1.
DR   STRING; 639283.Snov_0084; -.
DR   EnsemblBacteria; ADH87421; ADH87421; Snov_0084.
DR   KEGG; sno:Snov_0084; -.
DR   eggNOG; ENOG4105C1B; Bacteria.
DR   eggNOG; COG1088; LUCA.
DR   HOGENOM; HOG000168006; -.
DR   KO; K01710; -.
DR   OMA; KLIPLMC; -.
DR   OrthoDB; 707977at2; -.
DR   BioCyc; SNOV639283:G1GLM-84-MONOMER; -.
DR   Proteomes; UP000006633; Chromosome.
DR   GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR   CDD; cd05246; dTDP_GD_SDR_e; 1.
DR   InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01181; dTDP_gluc_dehyt; 1.
PE   3: Inferred from homology;
DR   PRODOM; D7A007.
DR   SWISS-2DPAGE; D7A007.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006633};
KW   Lyase {ECO:0000256|RuleBase:RU004473};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006633}.
FT   DOMAIN        9    327       NAD(P)-bd_dom. {ECO:0000259|Pfam:
FT                                PF16363}.
SQ   SEQUENCE   354 AA;  39539 MW;  19F6732874B427B1 CRC64;
     MTSIAQRVLV TGGAGFIGSA VVRRLVRQGR QVLTYDKLTY AGNLASLAEV HNLPGHSFLQ
     ADICDGRAFR EALESFRPDL VMHLAAESHV DRSIDGPGDF IATNIVGTYT LLDEALRYWR
     GLDAAAQKRF RFHHISTDEV FGTLGEDGLF REDTPYQPNS PYSASKAASD HLVRAWFHTY
     GLPVVMSNCS NNYGPYHFPE KLIPLTILNA LEGAPLPVYG KGENVRDWLY VEDHAAALEL
     IATRGRLGES YNVGGSNERR NIDVVRTICA IMDRVVPDAK IGPRDALIRF VTDRPGHDAR
     YAIDASKLKT ELGWVPEHDF ESGIEKTVRW YLDNAAWWEP LKARYNRARL GVAK
//

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