(data stored in SCRATCH zone)

SWISSPROT: D7A008_STAND

ID   D7A008_STAND            Unreviewed;       297 AA.
AC   D7A008;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 46.
DE   RecName: Full=dTDP-4-dehydrorhamnose reductase {ECO:0000256|RuleBase:RU364082};
DE            EC=1.1.1.133 {ECO:0000256|RuleBase:RU364082};
GN   OrderedLocusNames=Snov_0085 {ECO:0000313|EMBL:ADH87422.1};
OS   Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 /
OS   NBRC 12443 / NCIB 9113).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Xanthobacteraceae; Starkeya.
OX   NCBI_TaxID=639283 {ECO:0000313|EMBL:ADH87422.1, ECO:0000313|Proteomes:UP000006633};
RN   [1] {ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Brettin T., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Beatson S., Kappler U.,
RA   Woyke T.;
RT   "Complete sequence of Starkeya novella DSM 506.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADH87422.1, ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RX   PubMed=23450099; DOI=10.4056/sigs.3006378;
RA   Kappler U., Davenport K., Beatson S., Lucas S., Lapidus A.,
RA   Copeland A., Berry K.W., Glavina Del Rio T., Hammon N., Dalin E.,
RA   Tice H., Pitluck S., Richardson P., Bruce D., Goodwin L.A., Han C.,
RA   Tapia R., Detter J.C., Chang Y.J., Jeffries C.D., Land M., Hauser L.,
RA   Kyrpides N.C., Goker M., Ivanova N., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of the facultatively chemolithoautotrophic
RT   and methylotrophic alpha Proteobacterium Starkeya novella type strain
RT   (ATCC 8093(T)).";
RL   Stand. Genomic Sci. 7:44-58(2012).
CC   -!- FUNCTION: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-
CC       hexulose to yield dTDP-L-rhamnose.
CC       {ECO:0000256|RuleBase:RU364082}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-
CC         rhamnose + H(+) + NADPH; Xref=Rhea:RHEA:21796,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57510, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:62830; EC=1.1.1.133;
CC         Evidence={ECO:0000256|RuleBase:RU364082};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU364082};
CC       Note=Binds 1 Mg(2+) ion per monomer.
CC       {ECO:0000256|RuleBase:RU364082};
CC   -!- PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.
CC       {ECO:0000256|RuleBase:RU364082}.
CC   -!- SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose reductase
CC       family. {ECO:0000256|RuleBase:RU364082}.
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DR   EMBL; CP002026; ADH87422.1; -; Genomic_DNA.
DR   RefSeq; WP_013164927.1; NC_014217.1.
DR   STRING; 639283.Snov_0085; -.
DR   EnsemblBacteria; ADH87422; ADH87422; Snov_0085.
DR   KEGG; sno:Snov_0085; -.
DR   eggNOG; ENOG4105DBZ; Bacteria.
DR   eggNOG; COG1091; LUCA.
DR   HOGENOM; HOG000227712; -.
DR   KO; K00067; -.
DR   OMA; YHYSNEG; -.
DR   OrthoDB; 1076083at2; -.
DR   BioCyc; SNOV639283:G1GLM-85-MONOMER; -.
DR   UniPathway; UPA00124; -.
DR   Proteomes; UP000006633; Chromosome.
DR   GO; GO:0008831; F:dTDP-4-dehydrorhamnose reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019305; P:dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005913; dTDP_dehydrorham_reduct.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR029903; RmlD-like-bd.
DR   PANTHER; PTHR10491; PTHR10491; 1.
DR   Pfam; PF04321; RmlD_sub_bind; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01214; rmlD; 1.
PE   3: Inferred from homology;
DR   PRODOM; D7A008.
DR   SWISS-2DPAGE; D7A008.
KW   Complete proteome {ECO:0000313|Proteomes:UP000006633};
KW   NADP {ECO:0000256|RuleBase:RU364082};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU364082,
KW   ECO:0000313|EMBL:ADH87422.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006633}.
FT   DOMAIN        3    289       RmlD_sub_bind. {ECO:0000259|Pfam:
FT                                PF04321}.
SQ   SEQUENCE   297 AA;  31095 MW;  AF79E62C2C6B8685 CRC64;
     MTRVLLLGAG GQVGREIAAL APGRVESLTA LDHAGLDITD ASALKAALEQ YRPQVVINAA
     AYTAVDKAES EPEKANLINA VAPGLIAQAC ASHGAGLIHI STDYVFDGTK AGAYVESDPV
     APLGVYGASK EAGERAVRDS LDRHLIVRTS WVYGVHGANF LKTMLRLAET RDRLTVVADQ
     TGCPTATRDI AEGLLTAAMQ LATADVTPGT YHLAGTGVTT WHGFASVIVA HAARHTGRHV
     EVAPITTADY PTPARRPANS ELSSALFART VGYEAAPWQL RAAEVVDALF AAKQEAP
//

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