(data stored in SCRATCH zone)

SWISSPROT: D7A264_STAND

ID   D7A264_STAND            Unreviewed;       316 AA.
AC   D7A264;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   08-MAY-2019, entry version 56.
DE   RecName: Full=4-hydroxybenzoate octaprenyltransferase {ECO:0000256|HAMAP-Rule:MF_01635, ECO:0000256|SAAS:SAAS01075854};
DE            EC=2.5.1.- {ECO:0000256|HAMAP-Rule:MF_01635, ECO:0000256|SAAS:SAAS00336940};
DE   AltName: Full=4-HB polyprenyltransferase {ECO:0000256|HAMAP-Rule:MF_01635};
GN   Name=ubiA {ECO:0000256|HAMAP-Rule:MF_01635};
GN   OrderedLocusNames=Snov_0347 {ECO:0000313|EMBL:ADH87680.1};
OS   Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 /
OS   NBRC 12443 / NCIB 9113).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Xanthobacteraceae; Starkeya.
OX   NCBI_TaxID=639283 {ECO:0000313|EMBL:ADH87680.1, ECO:0000313|Proteomes:UP000006633};
RN   [1] {ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Brettin T., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Beatson S., Kappler U.,
RA   Woyke T.;
RT   "Complete sequence of Starkeya novella DSM 506.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADH87680.1, ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RX   PubMed=23450099; DOI=10.4056/sigs.3006378;
RA   Kappler U., Davenport K., Beatson S., Lucas S., Lapidus A.,
RA   Copeland A., Berry K.W., Glavina Del Rio T., Hammon N., Dalin E.,
RA   Tice H., Pitluck S., Richardson P., Bruce D., Goodwin L.A., Han C.,
RA   Tapia R., Detter J.C., Chang Y.J., Jeffries C.D., Land M., Hauser L.,
RA   Kyrpides N.C., Goker M., Ivanova N., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of the facultatively chemolithoautotrophic
RT   and methylotrophic alpha Proteobacterium Starkeya novella type strain
RT   (ATCC 8093(T)).";
RL   Stand. Genomic Sci. 7:44-58(2012).
CC   -!- FUNCTION: Catalyzes the prenylation of para-hydroxybenzoate (PHB)
CC       with an all-trans polyprenyl group. Mediates the second step in
CC       the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis,
CC       which is the condensation of the polyisoprenoid side chain with
CC       PHB, generating the first membrane-bound Q intermediate 3-
CC       octaprenyl-4-hydroxybenzoate. {ECO:0000256|HAMAP-Rule:MF_01635,
CC       ECO:0000256|SAAS:SAAS01075872}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-
CC         hydroxy-3-all-trans-octaprenylbenzoate + diphosphate;
CC         Xref=Rhea:RHEA:27782, ChEBI:CHEBI:1617, ChEBI:CHEBI:17879,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57711;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01635,
CC         ECO:0000256|SAAS:SAAS01114937};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01635, ECO:0000256|SAAS:SAAS01075861};
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_01635, ECO:0000256|SAAS:SAAS01075851}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01635, ECO:0000256|SAAS:SAAS01075873}; Multi-pass membrane
CC       protein {ECO:0000256|HAMAP-Rule:MF_01635,
CC       ECO:0000256|SAAS:SAAS01075873}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       {ECO:0000256|HAMAP-Rule:MF_01635, ECO:0000256|SAAS:SAAS01159762}.
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DR   EMBL; CP002026; ADH87680.1; -; Genomic_DNA.
DR   RefSeq; WP_013165185.1; NC_014217.1.
DR   STRING; 639283.Snov_0347; -.
DR   EnsemblBacteria; ADH87680; ADH87680; Snov_0347.
DR   KEGG; sno:Snov_0347; -.
DR   eggNOG; ENOG4105C4G; Bacteria.
DR   eggNOG; COG0382; LUCA.
DR   HOGENOM; HOG000003697; -.
DR   KO; K03179; -.
DR   OMA; WTLGFDT; -.
DR   OrthoDB; 1472516at2; -.
DR   BioCyc; SNOV639283:G1GLM-351-MONOMER; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000006633; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008412; F:4-hydroxybenzoate octaprenyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01635; UbiA; 1.
DR   InterPro; IPR006370; HB_polyprenyltransferase-like.
DR   InterPro; IPR039653; Prenyltransferase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR030470; UbiA_prenylTrfase_CS.
DR   PANTHER; PTHR11048; PTHR11048; 1.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01474; ubiA_proteo; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
DR   PRODOM; D7A264.
DR   SWISS-2DPAGE; D7A264.
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS01075859};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS01075855};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006633};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS01075847};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS00181105};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006633};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS00181134, ECO:0000313|EMBL:ADH87680.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS00181127};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS00181088};
KW   Ubiquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS01075866}.
FT   TRANSMEM     40     59       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM     71     96       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM    117    137       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM    143    161       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM    170    188       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM    194    213       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM    240    266       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
SQ   SEQUENCE   316 AA;  33505 MW;  0FBAB94B5FFBD000 CRC64;
     MTAPSTPAGP APADSAVSWV DRAPAALRPF LRLARIDRPI GSWLLLIPCW WSVALALGMQ
     ARAGEADYSR ALILGVLFAV GAVAMRGAGC TWNDILDRDI DVRVERTRAR PLPAGQVTLL
     GAFAFLALQA LVGLVVLICL PPFAIVTALA SLGLVAIYPL MKRVIWVPQA VLGLTFSWGA
     LMGFAALLEE LPAAAFLLYA GSVLWVIGYD TIYAHQDRED DALVGVKSSA RLFGRATKPW
     LVGFYAAAAA LIGVALVTAG AGPYAWGGLG IFVVQLGTQV RRLDIDDRAL CLKLFKSNRD
     AGLILLAGFL LDALVG
//

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