(data stored in ACNUC1104 zone)

SWISSPROT: D7CFB1_STRBB

ID   D7CFB1_STRBB            Unreviewed;       547 AA.
AC   D7CFB1;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   10-APR-2019, entry version 44.
DE   SubName: Full=EmrB/QacA family drug resistance transporter {ECO:0000313|EMBL:ADI13127.1};
GN   OrderedLocusNames=SBI_10009 {ECO:0000313|EMBL:ADI13127.1};
OS   Streptomyces bingchenggensis (strain BCW-1).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=749414 {ECO:0000313|EMBL:ADI13127.1, ECO:0000313|Proteomes:UP000000377};
RN   [1] {ECO:0000313|EMBL:ADI13127.1, ECO:0000313|Proteomes:UP000000377}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCW-1 {ECO:0000313|EMBL:ADI13127.1,
RC   ECO:0000313|Proteomes:UP000000377};
RX   PubMed=20581206; DOI=10.1128/JB.00596-10;
RA   Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L.,
RA   Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X.,
RA   Xiang W.S.;
RT   "Genome sequence of the milbemycin-producing bacterium Streptomyces
RT   bingchenggensis.";
RL   J. Bacteriol. 192:4526-4527(2010).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; CP002047; ADI13127.1; -; Genomic_DNA.
DR   RefSeq; WP_014182574.1; NC_016582.1.
DR   EnsemblBacteria; ADI13127; ADI13127; SBI_10009.
DR   KEGG; sbh:SBI_10009; -.
DR   PATRIC; fig|749414.3.peg.10307; -.
DR   eggNOG; ENOG410XNN3; LUCA.
DR   HOGENOM; HOG000239124; -.
DR   OMA; SWLCGIS; -.
DR   OrthoDB; 1108236at2; -.
DR   BioCyc; SBIN749414:G1GKW-10075-MONOMER; -.
DR   Proteomes; UP000000377; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; D7CFB1.
DR   SWISS-2DPAGE; D7CFB1.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000377};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000377};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM     12     39       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     51     70       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     82    101       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    140    158       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    170    189       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    201    220       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    232    254       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    274    298       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    310    328       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    340    359       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    371    390       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    502    520       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       16    450       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   547 AA;  56793 MW;  E1D71D867789545A CRC64;
     MSANGHRPRT ASPWAALAAL SLGLFMIVVD TSIVSVAVPT MVRSLNTGLN AVVWVTSVYL
     LMYAVPMLFT SRLGDRYGPK RVFVAGLAVF TGASLCAGLS ASVETLIASR AAQGLGAALL
     TPQTLTLITH LFPGGDRGRA MGVLGGASGL ATVTGPLLGG VLVDGLGWQW IFYVNVVVGV
     ATSALSLLVI PDWRPGHTHR FDMAGILLSG AGLFLIVFGI QNGQTYDWGE LLGPITVFHV
     IAVGVALLVA FVIWQRVNRN EPLVPLRTFA DRNFSMGALT TAALGFTLTG MFLPLVIYLQ
     SALGLSPTDA GLVTAPMALV SGLMGPFIGR LSDRVSGKYL VMSGLLGMAL GLGIIALQAE
     AELPPWQLTP GLLVCGLGMG FVLVPVNNVA MGTVPAELRG AASGIFFTAR QLGAVLGSAT
     IGVLLQMRIV TATANAADTA SAHLPARYRR DFLEYMRDTP SQAAGAPGTE TSLALPGHLA
     RQGQQLAEQA VRNGLTQAAK ETLIPLIAVL LLGTLAGAAM RRTKPVSGPP GPADYSTPLS
     TTRKGSP
//

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