(data stored in SCRATCH zone)

SWISSPROT: E3J3I4_FRAIE

ID   E3J3I4_FRAIE            Unreviewed;       299 AA.
AC   E3J3I4;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   08-MAY-2019, entry version 41.
DE   RecName: Full=1,4-dihydroxy-6-naphtoate synthase {ECO:0000256|HAMAP-Rule:MF_00996};
DE            EC=4.1.-.- {ECO:0000256|HAMAP-Rule:MF_00996};
DE   AltName: Full=Menaquinone biosynthetic enzyme MqnD {ECO:0000256|HAMAP-Rule:MF_00996};
GN   Name=mqnD {ECO:0000256|HAMAP-Rule:MF_00996};
GN   OrderedLocusNames=FraEuI1c_0098 {ECO:0000313|EMBL:ADP78186.1};
OS   Frankia inefficax (strain DSM 45817 / CECT 9037 / EuI1c).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298654 {ECO:0000313|EMBL:ADP78186.1, ECO:0000313|Proteomes:UP000002484};
RN   [1] {ECO:0000313|EMBL:ADP78186.1, ECO:0000313|Proteomes:UP000002484}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45817 / CECT 9037 / EuI1c
RC   {ECO:0000313|Proteomes:UP000002484};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA   Beauchemin N., Sen A., Sur S.A., Gtari M., Wall L., Tisa L., Woyke T.;
RT   "Complete sequence of Frankia sp. EuI1c.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the conversion of cyclic dehypoxanthine
CC       futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step
CC       in the biosynthesis of menaquinone (MK, vitamin K2).
CC       {ECO:0000256|HAMAP-Rule:MF_00996}.
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00996}.
CC   -!- SIMILARITY: Belongs to the MqnA/MqnD family. MqnD subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00996}.
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DR   EMBL; CP002299; ADP78186.1; -; Genomic_DNA.
DR   RefSeq; WP_013421309.1; NC_014666.1.
DR   STRING; 298654.FraEuI1c_0098; -.
DR   EnsemblBacteria; ADP78186; ADP78186; FraEuI1c_0098.
DR   KEGG; fri:FraEuI1c_0098; -.
DR   eggNOG; ENOG4105E63; Bacteria.
DR   eggNOG; COG2107; LUCA.
DR   HOGENOM; HOG000013596; -.
DR   KO; K11785; -.
DR   OMA; RGCGPLV; -.
DR   OrthoDB; 1107067at2; -.
DR   BioCyc; FSP298654:G1GOT-99-MONOMER; -.
DR   UniPathway; UPA00079; -.
DR   Proteomes; UP000002484; Chromosome.
DR   GO; GO:0016830; F:carbon-carbon lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00996; MqnD; 1.
DR   InterPro; IPR003773; Menaquinone_biosynth.
DR   InterPro; IPR030869; MqnD.
DR   PANTHER; PTHR37167; PTHR37167; 1.
DR   Pfam; PF02621; VitK2_biosynth; 1.
PE   3: Inferred from homology;
DR   PRODOM; E3J3I4.
DR   SWISS-2DPAGE; E3J3I4.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002484};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00996};
KW   Menaquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_00996};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002484}.
FT   REGION       69     71       Substrate binding. {ECO:0000256|HAMAP-
FT                                Rule:MF_00996}.
FT   REGION      131    132       Substrate binding. {ECO:0000256|HAMAP-
FT                                Rule:MF_00996}.
FT   ACT_SITE    172    172       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_00996}.
SQ   SEQUENCE   299 AA;  31005 MW;  3462594F0D4F9807 CRC64;
     MSQVTAASEA DQRERTGLTL AISPCPNDTF AFHALAHGLV PGVPPVSVTF ADIDVLNARA
     ADGLDDLVKV SYAALPWLLD GYRLLPAGGA LGRGCGPLVL MSAGGPTAAG AQGDAAVLRG
     ARVAIPGTRT TAYLLFRLWA AGIDVATIDV LPFEKIMPAV QAGRYDAGLV IHESRFTYPS
     YGLVSVADLG DWWEGATGLP IPLGAILARR DLPAESGDLA AAVRASVAAA FANPAASAAW
     VLEHSQELAP EVVQAHIDLY VNDFSLDLGD EGYAAAEELL ARAAAENLVP PLPSPLRQP
//

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