(data stored in SCRATCH zone)

SWISSPROT: E6S626_INTC7

ID   E6S626_INTC7            Unreviewed;       774 AA.
AC   E6S626;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 57.
DE   SubName: Full=Heavy metal translocating P-type ATPase {ECO:0000313|EMBL:ADU46766.1};
GN   OrderedLocusNames=Intca_0209 {ECO:0000313|EMBL:ADU46766.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 /
OS   NBRC 12989 / 7 KIP).
OC   Bacteria; Actinobacteria; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU46766.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU46766.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S.,
RA   Cheng J.F., Detter C., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Pukall R., Sikorski J., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7
RT   KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU362081}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type)
CC       (TC 3.A.3) family. Type IB subfamily.
CC       {ECO:0000256|RuleBase:RU362081}.
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DR   EMBL; CP002343; ADU46766.1; -; Genomic_DNA.
DR   RefSeq; WP_013491088.1; NC_014830.1.
DR   STRING; 710696.Intca_0209; -.
DR   EnsemblBacteria; ADU46766; ADU46766; Intca_0209.
DR   KEGG; ica:Intca_0209; -.
DR   eggNOG; ENOG4105C59; Bacteria.
DR   eggNOG; COG2217; LUCA.
DR   HOGENOM; HOG000250397; -.
DR   KO; K17686; -.
DR   OrthoDB; 237367at2; -.
DR   BioCyc; ICAL710696:GH9U-213-MONOMER; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019829; F:cation-transporting ATPase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030001; P:metal ion transport; IEA:InterPro.
DR   CDD; cd00371; HMA; 1.
DR   Gene3D; 3.40.1110.10; -; 1.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR017969; Heavy-metal-associated_CS.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   InterPro; IPR027256; P-typ_ATPase_IB.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   Pfam; PF00403; HMA; 1.
DR   PRINTS; PR00120; HATPASE.
DR   SUPFAM; SSF55008; SSF55008; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   SUPFAM; SSF81653; SSF81653; 1.
DR   SUPFAM; SSF81665; SSF81665; 1.
DR   TIGRFAMs; TIGR01525; ATPase-IB_hvy; 1.
DR   TIGRFAMs; TIGR01494; ATPase_P-type; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
DR   PROSITE; PS01047; HMA_1; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; E6S626.
DR   SWISS-2DPAGE; E6S626.
KW   ATP-binding {ECO:0000256|RuleBase:RU362081};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008914};
KW   Membrane {ECO:0000256|RuleBase:RU362081};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00280,
KW   ECO:0000256|RuleBase:RU362081};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914};
KW   Transmembrane {ECO:0000256|RuleBase:RU362081};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    119    136       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    142    160       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    180    203       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    223    241       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    379    399       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    405    428       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    724    740       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM    746    764       Helical. {ECO:0000256|RuleBase:RU362081}.
FT   DOMAIN       22     86       HMA. {ECO:0000259|PROSITE:PS50846}.
FT   COILED      358    378       {ECO:0000256|SAM:Coils}.
FT   METAL        32     32       {ECO:0000256|PROSITE-ProRule:PRU00280}.
FT   METAL        35     35       {ECO:0000256|PROSITE-ProRule:PRU00280}.
SQ   SEQUENCE   774 AA;  79655 MW;  F0645F2B8F51DADE CRC64;
     MTTTPTTTPG GASLGLPSAP GAIELEITGM TCASCANRIE RKLNKLDGVT ATVNYATEKA
     KVSFPDTLSA EELVKAVEAA GYGATVPAPP VTAEGAEGPS GGEASPAAYD RVRALRDRLV
     VSAVLSLPVI AMAMVSALQF DYWQWASLTL AAPVVVWGAW PFHKAAWTNL RHGTTTMDTL
     VSMGVLAAFG WSLYALFLGT AGMPGMVHPF ELTISRTDGA GNIYLEAAAG VTTFLLAGRY
     FEARSKRQAG AALRALLELG AKDVSVLRDG LSGQVEERIP TSQLQVGMRF VVRPGEKIAT
     DGVVEDGTSA VDAAMLTGES VPVEVGPGSA VAGATINAGG RIVVRATRVG SDTQLAQMAR
     LVEDAQNGKA QVQRLADRIS GFFVPIVIGL SAATLGFWLG TGAGAAAAFT AAVAVLIIAC
     PCALGLATPT ALMVGTGRGA QLGILIKGPE VLESTRQVDT IVLDKTGTVT TGAMALHAVV
     AADGEDEAEV LRLAGAVEDA SEHPVARAVA AGAKERLGAL PAVSGFESTQ GLGVRGEVDG
     SDVYVGRPVF LAERRQMRCT ELDAAATEHE SQGSTVVAVA WGGRMRGILV VADTIKTTSA
     QAIQELRDLG LTPILLTGDN ERVARTVAAQ VGIAEADVIA DVLPADKVDV VKRLQESGKV
     VAMVGDGVND AAALAQADLG LAMGTGTDVA IEASDLTLVR GDLRVAADAI RLARRTLRTI
     KGNLFWAFAY NVAAIPLAAA GLLNPMLAGA AMAFSSVFVV SNSLRLRGFR ATAA
//

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