(data stored in SCRATCH zone)

SWISSPROT: E6S6R3_INTC7

ID   E6S6R3_INTC7            Unreviewed;       398 AA.
AC   E6S6R3;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 43.
DE   RecName: Full=Nuclease SbcCD subunit D {ECO:0000256|RuleBase:RU363069};
GN   Name=sbcD {ECO:0000256|RuleBase:RU363069};
GN   OrderedLocusNames=Intca_0242 {ECO:0000313|EMBL:ADU46799.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 /
OS   NBRC 12989 / 7 KIP).
OC   Bacteria; Actinobacteria; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU46799.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU46799.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S.,
RA   Cheng J.F., Detter C., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Pukall R., Sikorski J., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7
RT   KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
CC   -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures
CC       can inhibit DNA replication and are intermediates in certain DNA
CC       recombination reactions. The complex acts as a 3'->5' double
CC       strand exonuclease that can open hairpins. It also has a 5'
CC       single-strand endonuclease activity.
CC       {ECO:0000256|RuleBase:RU363069}.
CC   -!- SUBUNIT: Heterodimer of SbcC and SbcD.
CC       {ECO:0000256|RuleBase:RU363069}.
CC   -!- SIMILARITY: Belongs to the SbcD family.
CC       {ECO:0000256|RuleBase:RU363069}.
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DR   EMBL; CP002343; ADU46799.1; -; Genomic_DNA.
DR   RefSeq; WP_013491121.1; NC_014830.1.
DR   STRING; 710696.Intca_0242; -.
DR   EnsemblBacteria; ADU46799; ADU46799; Intca_0242.
DR   KEGG; ica:Intca_0242; -.
DR   eggNOG; ENOG4105DM0; Bacteria.
DR   eggNOG; COG0420; LUCA.
DR   HOGENOM; HOG000026260; -.
DR   KO; K03547; -.
DR   OrthoDB; 1831911at2; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00840; MPP_Mre11_N; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041796; Mre11_N.
DR   InterPro; IPR004593; SbcD.
DR   InterPro; IPR026843; SbcD_C.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF12320; SbcD_C; 1.
DR   TIGRFAMs; TIGR00619; sbcd; 1.
PE   3: Inferred from homology;
DR   PRODOM; E6S6R3.
DR   SWISS-2DPAGE; E6S6R3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008914};
KW   DNA recombination {ECO:0000256|RuleBase:RU363069};
KW   DNA replication {ECO:0000256|RuleBase:RU363069};
KW   Endonuclease {ECO:0000256|RuleBase:RU363069};
KW   Exonuclease {ECO:0000256|RuleBase:RU363069};
KW   Hydrolase {ECO:0000256|RuleBase:RU363069};
KW   Nuclease {ECO:0000256|RuleBase:RU363069};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914}.
FT   DOMAIN        1     97       Metallophos. {ECO:0000259|Pfam:PF00149}.
FT   DOMAIN      277    359       SbcD_C. {ECO:0000259|Pfam:PF12320}.
SQ   SEQUENCE   398 AA;  42794 MW;  755D28C6AC9522D5 CRC64;
     MRMLHTSDWH LGRTLHGVSL HEAQAAVLER ICELVEDPPD GVPVDAVIVA GDVYDRGVPP
     VESVQLFEWT LSRLSQVTTV VVTSGNHDSA IRLGYGAGLF RDTIRMITDL SMVDLPVLLD
     GSDGVRAAIY GIPYLDVDHA RAALARGGEL LPRSHQAVVG AACDRIREDL RARTGVRSVV
     VAHAFVAGAE PSDSERSIAV GGVDRVAGTV FAGLDYAALG HLHGPQSPEC AEGSVVRYSG
     SPLRYSFSEQ DHAKCVLLVD LPAAGPVVVT PLPITQPRPM ATLRGMLDDL LADPAHAMHE
     DAWLRVTLTD RVRPDSLMDR LKSRFPHVLQ VFHEPDGRIE RGVRGTTAVS ERDPRELGSD
     FISYVTKTEA STGEIGCFVA GYEAAVKAQA LAEAQEVA
//

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