(data stored in SCRATCH zone)

SWISSPROT: E6S822_INTC7

ID   E6S822_INTC7            Unreviewed;       399 AA.
AC   E6S822;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 37.
DE   SubName: Full=Beta-ketoadipyl CoA thiolase {ECO:0000313|EMBL:ADU46926.1};
DE            EC=2.3.1.9 {ECO:0000313|EMBL:ADU46926.1};
GN   OrderedLocusNames=Intca_0377 {ECO:0000313|EMBL:ADU46926.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 /
OS   NBRC 12989 / 7 KIP).
OC   Bacteria; Actinobacteria; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU46926.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU46926.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S.,
RA   Cheng J.F., Detter C., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Pukall R., Sikorski J., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7
RT   KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
CC   -!- SIMILARITY: Belongs to the thiolase family.
CC       {ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; CP002343; ADU46926.1; -; Genomic_DNA.
DR   RefSeq; WP_013491247.1; NC_014830.1.
DR   STRING; 710696.Intca_0377; -.
DR   EnsemblBacteria; ADU46926; ADU46926; Intca_0377.
DR   KEGG; ica:Intca_0377; -.
DR   eggNOG; ENOG4105CHU; Bacteria.
DR   eggNOG; COG0183; LUCA.
DR   HOGENOM; HOG000012239; -.
DR   OrthoDB; 550338at2; -.
DR   BioCyc; ICAL710696:GH9U-386-MONOMER; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019619; P:3,4-dihydroxybenzoate catabolic process; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012793; PcaF.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR01930; AcCoA-C-Actrans; 1.
DR   TIGRFAMs; TIGR02430; pcaF; 1.
DR   PROSITE; PS00098; THIOLASE_1; 1.
DR   PROSITE; PS00737; THIOLASE_2; 1.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; E6S822.
DR   SWISS-2DPAGE; E6S822.
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:ADU46926.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008914};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914};
KW   Transferase {ECO:0000256|RuleBase:RU003557,
KW   ECO:0000313|EMBL:ADU46926.1}.
FT   DOMAIN        5    266       Thiolase_N. {ECO:0000259|Pfam:PF00108}.
FT   DOMAIN      274    397       Thiolase_C. {ECO:0000259|Pfam:PF02803}.
FT   ACT_SITE     90     90       Acyl-thioester intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR000429-1}.
FT   ACT_SITE    355    355       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
FT   ACT_SITE    385    385       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000429-1}.
SQ   SEQUENCE   399 AA;  41243 MW;  BAF3A512E3101B9F CRC64;
     MSTAYLVAGV RTPIGRYAGG LAPVRTDDLA AHAVSSLVDR FPAIDWGRVD DVILGCANQA
     GEDNRNVARM AGLLAGLPVQ VPGLTVNRLC ASGLDAVGAA ARAIRAGDAD LVIAGGVESM
     TRAPLVMPKP DSAWSRRAEV HDTTIGWRFV NPRMDERYGT DSMPGTAQIV ADEYDISRED
     QDAFALRSQE RAAKAIASGR LAREIVPVEI QGRKGAVSVV DTDEHPRTTS LEALANLRPI
     FPGGSVTAGN ASGVNDGAAA LLVASEAAVS RYGLTPLARI TTSLSVGVEP RVMGMGPDPA
     VKALLARTGL EVGDIDLFEL NEAFASQSLA VLRALGLPDD AEHVNPNGGA IALGHPLGMS
     GARLALTAAV ELADRGVRRA LATMCVGVGQ GGALLLEAV
//

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