(data stored in SCRATCH zone)

SWISSPROT: E6S837_INTC7

ID   E6S837_INTC7            Unreviewed;       456 AA.
AC   E6S837;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   13-FEB-2019, entry version 44.
DE   RecName: Full=NAD(P) transhydrogenase subunit beta {ECO:0000256|PIRNR:PIRNR000204};
DE            EC=7.1.1.1 {ECO:0000256|PIRNR:PIRNR000204};
DE   AltName: Full=Nicotinamide nucleotide transhydrogenase subunit beta {ECO:0000256|PIRNR:PIRNR000204};
GN   OrderedLocusNames=Intca_0392 {ECO:0000313|EMBL:ADU46941.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 /
OS   NBRC 12989 / 7 KIP).
OC   Bacteria; Actinobacteria; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU46941.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU46941.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S.,
RA   Cheng J.F., Detter C., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Pukall R., Sikorski J., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7
RT   KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
CC   -!- FUNCTION: The transhydrogenation between NADH and NADP is coupled
CC       to respiration and ATP hydrolysis and functions as a proton pump
CC       across the membrane. {ECO:0000256|PIRNR:PIRNR000204}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+);
CC         Xref=Rhea:RHEA:47992, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349;
CC         EC=7.1.1.1; Evidence={ECO:0000256|PIRNR:PIRNR000204};
CC   -!- SIMILARITY: Belongs to the PNT beta subunit family.
CC       {ECO:0000256|PIRNR:PIRNR000204}.
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DR   EMBL; CP002343; ADU46941.1; -; Genomic_DNA.
DR   RefSeq; WP_013491262.1; NC_014830.1.
DR   STRING; 710696.Intca_0392; -.
DR   EnsemblBacteria; ADU46941; ADU46941; Intca_0392.
DR   KEGG; ica:Intca_0392; -.
DR   eggNOG; ENOG4105C15; Bacteria.
DR   eggNOG; COG1282; LUCA.
DR   HOGENOM; HOG000243958; -.
DR   KO; K00325; -.
DR   OrthoDB; 788546at2; -.
DR   BioCyc; ICAL710696:GH9U-401-MONOMER; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008750; F:NAD(P)+ transhydrogenase (AB-specific) activity; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR012136; NADH_DH_b.
DR   InterPro; IPR034300; PNTB-like.
DR   Pfam; PF02233; PNTB; 1.
DR   PIRSF; PIRSF000204; PNTB; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
PE   3: Inferred from homology;
DR   PRODOM; E6S837.
DR   SWISS-2DPAGE; E6S837.
KW   Cell inner membrane {ECO:0000256|PIRNR:PIRNR000204};
KW   Cell membrane {ECO:0000256|PIRNR:PIRNR000204};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008914};
KW   Membrane {ECO:0000256|PIRNR:PIRNR000204, ECO:0000256|SAM:Phobius};
KW   NAD {ECO:0000256|PIRNR:PIRNR000204};
KW   NADP {ECO:0000256|PIRNR:PIRNR000204};
KW   Oxidoreductase {ECO:0000313|EMBL:ADU46941.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914};
KW   Translocase {ECO:0000256|PIRNR:PIRNR000204};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM      6     23       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     35     52       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     58     78       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     90    111       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    123    144       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    160    179       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    185    203       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    234    253       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        7    454       PNTB. {ECO:0000259|Pfam:PF02233}.
SQ   SEQUENCE   456 AA;  47903 MW;  9CCC3F2A994C9AA3 CRC64;
     MELSLITAAY IIAAILFILS LAGLSKHETA KDGNVLGMVG MGLALLATLW LAGRSAEWLN
     WGLIAVAVAI GATIGVTKAR KVEMTGMPEL IAMLHSFVGL AAVLVGYNSF LTGSTDSVHS
     VEVFLGVFIG AVTFTGSIVA YLKLSAKISG APLMLPGRHW LNLLAGVVSV GLMIWFVAAH
     SIVPLLVMTA IALAFGWHLV ASIGGGDMPV VVSMLNSYSG WAAAAAGFML GNDLLIVTGA
     LVGSSGAYLS YIMSKAMNRK FLSVIAGGFG QDGGKPAGDV DYGDHRETNP SEVADLLVHA
     RSVVITPGYG MAVAQAQYPV AELTSRLREK GVNVRFGIHP VAGRLPGHMN VLLAEAKVPY
     DIVLEMDEIN GDLPETDVVL VIGANDTVNP SAEEDPNSPI AGMPVLEVWK AKDVVVFKRS
     MAAGYAGVQN PLFFRDNSAM LFGDAKDRVE DIIKAL
//

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