(data stored in SCRATCH zone)

SWISSPROT: E6S8P8_INTC7

ID   E6S8P8_INTC7            Unreviewed;       101 AA.
AC   E6S8P8;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-JAN-2019, entry version 35.
DE   RecName: Full=Transcriptional regulator WhiB {ECO:0000256|HAMAP-Rule:MF_01479};
GN   Name=whiB {ECO:0000256|HAMAP-Rule:MF_01479};
GN   OrderedLocusNames=Intca_0470 {ECO:0000313|EMBL:ADU47017.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 /
OS   NBRC 12989 / 7 KIP).
OC   Bacteria; Actinobacteria; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU47017.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU47017.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S.,
RA   Cheng J.F., Detter C., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Pukall R., Sikorski J., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7
RT   KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
CC   -!- FUNCTION: Acts as a transcriptional regulator. Probably redox-
CC       responsive. The apo- but not holo-form probably binds DNA.
CC       {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01479};
CC       Note=Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation
CC       of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
CC       {ECO:0000256|HAMAP-Rule:MF_01479};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- PTM: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
CC       {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- PTM: Upon Fe-S cluster removal intramolecular disulfide bonds are
CC       formed. {ECO:0000256|HAMAP-Rule:MF_01479}.
CC   -!- SIMILARITY: Belongs to the WhiB family. {ECO:0000256|HAMAP-
CC       Rule:MF_01479}.
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DR   EMBL; CP002343; ADU47017.1; -; Genomic_DNA.
DR   RefSeq; WP_013491338.1; NC_014830.1.
DR   STRING; 710696.Intca_0470; -.
DR   EnsemblBacteria; ADU47017; ADU47017; Intca_0470.
DR   KEGG; ica:Intca_0470; -.
DR   eggNOG; ENOG4105N0U; Bacteria.
DR   eggNOG; ENOG4111W0R; LUCA.
DR   HOGENOM; HOG000247629; -.
DR   KO; K18955; -.
DR   OrthoDB; 1929976at2; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0035731; F:dinitrosyl-iron complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01479; WhiB; 1.
DR   InterPro; IPR034768; 4FE4S_WBL.
DR   InterPro; IPR003482; Whib.
DR   PANTHER; PTHR38839; PTHR38839; 1.
DR   Pfam; PF02467; Whib; 1.
DR   PROSITE; PS51674; 4FE4S_WBL; 1.
PE   3: Inferred from homology;
DR   PRODOM; E6S8P8.
DR   SWISS-2DPAGE; E6S8P8.
KW   4Fe-4S {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008914};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Disulfide bond {ECO:0000256|HAMAP-Rule:MF_01479};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Iron {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Iron-sulfur {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_01479};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   DOMAIN       19     75       4Fe-4S Wbl-type. {ECO:0000259|PROSITE:
FT                                PS51674}.
FT   METAL        20     20       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        20     20       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        42     42       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        42     42       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        45     45       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        45     45       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        51     51       Dinitrosyliron [4Fe-8(NO)]; alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
FT   METAL        51     51       Iron-sulfur (4Fe-4S); alternate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01479}.
SQ   SEQUENCE   101 AA;  11114 MW;  87781A322F005E86 CRC64;
     MSVATISTTW FDEWASQAAC TGKDPDALFV RGKAQHEAKA VCKTCPVLAQ CLAEALDNRT
     EFGVWGGMTE RERRALLRKR PDITSWKLAL RAGMEAQAKS A
//

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