(data stored in SCRATCH zone)

SWISSPROT: E6S8S6_INTC7

ID   E6S8S6_INTC7            Unreviewed;       445 AA.
AC   E6S8S6;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   10-APR-2019, entry version 49.
DE   RecName: Full=Na(+)/H(+) antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
DE   AltName: Full=Sodium/proton antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN   Name=nhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN   OrderedLocusNames=Intca_0498 {ECO:0000313|EMBL:ADU47045.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 /
OS   NBRC 12989 / 7 KIP).
OC   Bacteria; Actinobacteria; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU47045.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU47045.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S.,
RA   Cheng J.F., Detter C., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Pukall R., Sikorski J., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7
RT   KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons. {ECO:0000256|HAMAP-Rule:MF_01844,
CC       ECO:0000256|SAAS:SAAS00895465}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01844}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01844}.
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family. {ECO:0000256|HAMAP-Rule:MF_01844,
CC       ECO:0000256|SAAS:SAAS00895449}.
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DR   EMBL; CP002343; ADU47045.1; -; Genomic_DNA.
DR   RefSeq; WP_013491366.1; NC_014830.1.
DR   EnsemblBacteria; ADU47045; ADU47045; Intca_0498.
DR   KEGG; ica:Intca_0498; -.
DR   eggNOG; ENOG4105DRC; Bacteria.
DR   eggNOG; COG3004; LUCA.
DR   HOGENOM; HOG000218489; -.
DR   KO; K03313; -.
DR   OrthoDB; 1805428at2; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 1.20.1530.10; -; 1.
DR   HAMAP; MF_01844; NhaA; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR   InterPro; IPR004670; NhaA.
DR   PANTHER; PTHR30341; PTHR30341; 1.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
DR   TIGRFAMs; TIGR00773; NhaA; 1.
PE   3: Inferred from homology;
DR   PRODOM; E6S8S6.
DR   SWISS-2DPAGE; E6S8S6.
KW   Antiport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00895439};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00919182};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008914};
KW   Ion transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00895467};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00919187};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914};
KW   Sodium {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00895461};
KW   Sodium transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00895442};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00919180};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00919177};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00895454}.
FT   TRANSMEM     31     50       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM     75     93       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    114    136       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    148    169       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    181    200       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    206    222       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    227    243       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    249    268       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    288    313       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    319    342       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    354    381       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    393    412       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
SQ   SEQUENCE   445 AA;  47308 MW;  839EC9E8CB4400FF CRC64;
     MTLPPRPTSR LLGRGSWRES RYVADILRQE TVGGTLLLIA AVAAIVWANS PWREAYSALR
     DTTVGPQSLH LDLSLGEWAA DGLLAVFFLV AGIELKREFV AGDLADRRKA ALPIVAAAAG
     VAVPAILFVI TATLVASGDD ATQLSGILRG WAIPTATDIA FALAVLAVIG THLPSALRSF
     LLTLAVVDDL IAITIIAIFY TQSLNLLWLA AAIVPLAAWR FLLQRKITNP FVLAIPGILA
     WGFVHSSGIH ATVAGVLLGL LVPVNRAIED DPDRHSLAER IEHKIRPFSA GFAVPVFAFF
     AAGVTVIGGG FSAALSDPAA LGVIVGLVLG KPIGIFGSTW AMSRFTRAEL DSGLAWTDVL
     GLSMLAGVGF TVSLLIGDLA FGLGSERDEH VKFAILFGSL IASLFAAVVL RLRNRVYRRI
     HEQELRDSDR DGIPDVYDAS PGHPD
//

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