(data stored in SCRATCH zone)

SWISSPROT: E6SEK9_INTC7

ID   E6SEK9_INTC7            Unreviewed;       627 AA.
AC   E6SEK9;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 52.
DE   RecName: Full=Na(+)/H(+) antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
DE   AltName: Full=Sodium/proton antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN   Name=nhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN   OrderedLocusNames=Intca_0048 {ECO:0000313|EMBL:ADU46610.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 /
OS   NBRC 12989 / 7 KIP).
OC   Bacteria; Actinobacteria; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU46610.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU46610.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S.,
RA   Cheng J.F., Detter C., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Pukall R., Sikorski J., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7
RT   KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons. {ECO:0000256|HAMAP-Rule:MF_01844}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01844}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01844}.
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family. {ECO:0000256|HAMAP-Rule:MF_01844}.
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DR   EMBL; CP002343; ADU46610.1; -; Genomic_DNA.
DR   RefSeq; WP_013490932.1; NC_014830.1.
DR   STRING; 710696.Intca_0048; -.
DR   EnsemblBacteria; ADU46610; ADU46610; Intca_0048.
DR   KEGG; ica:Intca_0048; -.
DR   eggNOG; ENOG4105DRC; Bacteria.
DR   eggNOG; COG1651; LUCA.
DR   eggNOG; COG3004; LUCA.
DR   HOGENOM; HOG000218489; -.
DR   OrthoDB; 1805428at2; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 1.20.1530.10; -; 1.
DR   HAMAP; MF_01844; NhaA; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR   InterPro; IPR004670; NhaA.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR30341; PTHR30341; 1.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
DR   Pfam; PF13462; Thioredoxin_4; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR00773; NhaA; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; E6SEK9.
DR   SWISS-2DPAGE; E6SEK9.
KW   Antiport {ECO:0000256|HAMAP-Rule:MF_01844};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00919182};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008914};
KW   Ion transport {ECO:0000256|HAMAP-Rule:MF_01844};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00919187};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914};
KW   Sodium {ECO:0000256|HAMAP-Rule:MF_01844};
KW   Sodium transport {ECO:0000256|HAMAP-Rule:MF_01844};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00919180};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00919177};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_01844}.
FT   TRANSMEM     24     46       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM     75     93       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    114    131       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    143    162       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    169    190       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    196    213       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    225    252       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    305    323       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    335    356       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    376    398       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    410    431       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   DOMAIN      416    614       Thioredoxin. {ECO:0000259|PROSITE:
FT                                PS51352}.
SQ   SEQUENCE   627 AA;  66858 MW;  E53C4BF744EC4384 CRC64;
     MATTTTAPRR HQLGGQLSAP LRRFLATESG GAVLLVVATL VALGWANSTW SETYSRIWST
     ELAVEVADWA LRMDLHHWIN DGLMAVFFLV IGLEVRRDLS VGELTDRRKL RLPLLAGLGG
     MVVPAVLYLL VNSSGEAANG WGVVIGTDTA FLLGTLALVG PATSTQLRVF LLTLTVVDDI
     VAVSVIGLVY SDDLDAVALA VALAAVAVLV ALGRSRVWRT WPYALTILAL WLATVASGLH
     ASVAGMVAGL LVPSFAPRRQ AVEQAARRFH AFRQSPLADV GRSAQDALVR AVPVNERMQL
     VLHPWTSYFI VPVFALANAG VDLRGGVLGE ALRSPVTWGI VLGLVLGKFV GIGGVALLGS
     RLGVGRLPQG VGPGQILGGG ALSGIGFTVS LLIVGLAFGP ELQDEATVGV LLALVLATLL
     GWLVFTLAAV LHGETTAGLP TVLDRPVDPE RDHVRGSVTA PLTLVEYADF ECPFCGRATG
     VVAEVRAHFG ADLRYVMRHL PLPDVHPHAE LAALAVESAG AQGRFWEMHD LLFEHQGQLE
     TEDLAGYASE LGLDVERFLR DLDDEVHSDR IREDVRSAEA SGARGTPTFF VGDQRHVGPY
     DAQTLIAELE ASRRDPAREE RPRAGHA
//

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