(data stored in SCRATCH zone)

SWISSPROT: E6SEL2_INTC7

ID   E6SEL2_INTC7            Unreviewed;       604 AA.
AC   E6SEL2;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 34.
DE   RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN   OrderedLocusNames=Intca_0051 {ECO:0000313|EMBL:ADU46613.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 /
OS   NBRC 12989 / 7 KIP).
OC   Bacteria; Actinobacteria; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU46613.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU46613.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S.,
RA   Cheng J.F., Detter C., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Pukall R., Sikorski J., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7
RT   KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
CC   -!- FUNCTION: Transports L-lactate across the membrane. Can also
CC       transport D-lactate and glycolate.
CC       {ECO:0000256|RuleBase:RU365092}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU365092}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU365092}.
CC   -!- SIMILARITY: Belongs to the lactate permease family.
CC       {ECO:0000256|RuleBase:RU365092}.
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DR   EMBL; CP002343; ADU46613.1; -; Genomic_DNA.
DR   RefSeq; WP_013490935.1; NC_014830.1.
DR   STRING; 710696.Intca_0051; -.
DR   EnsemblBacteria; ADU46613; ADU46613; Intca_0051.
DR   KEGG; ica:Intca_0051; -.
DR   eggNOG; ENOG4105DAA; Bacteria.
DR   eggNOG; COG1620; LUCA.
DR   HOGENOM; HOG000253321; -.
DR   KO; K03303; -.
DR   OrthoDB; 732251at2; -.
DR   BioCyc; ICAL710696:GH9U-54-MONOMER; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003804; Lactate_perm.
DR   PANTHER; PTHR30003; PTHR30003; 1.
DR   Pfam; PF02652; Lactate_perm; 2.
PE   3: Inferred from homology;
DR   PRODOM; E6SEL2.
DR   SWISS-2DPAGE; E6SEL2.
KW   Cell membrane {ECO:0000256|RuleBase:RU365092};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008914};
KW   Membrane {ECO:0000256|RuleBase:RU365092};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914};
KW   Transmembrane {ECO:0000256|RuleBase:RU365092};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU365092};
KW   Transport {ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM     20     45       Helical. {ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM     52     73       Helical. {ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM     85    108       Helical. {ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM    129    146       Helical. {ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM    211    229       Helical. {ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM    265    283       Helical. {ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM    360    380       Helical. {ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM    418    439       Helical. {ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM    459    477       Helical. {ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM    483    504       Helical. {ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM    581    603       Helical. {ECO:0000256|RuleBase:RU365092}.
SQ   SEQUENCE   604 AA;  61687 MW;  DF48F37C452636DA CRC64;
     MLATFPIVTG LAADDFTQSL APVGGSLALS ALVGLLPLVV VFLLLGVLKT QAWVAALAGL
     GTAVLVAVLG YGMPASLALM SATQGGVFGV FPIMWIVLTA LWLYQLTVTS GRFEDLRATF
     NMVSEDPRIQ AVLIAFCFGG LLEALAGFGA PVAITATMLI ALGVAPLRAA GTVLLANTAP
     VAFGAIAIPI TTAATLTGIP ESTIGAIVGR QAPLLAVVVP LLLLLVVDGK RGLREVWPAA
     LVTGLSFAVA QFLTSNFLSV ALTDIVASLA GLGATVLFLR VWTPVGAREA HERLEAGRHQ
     EHAAAVAAGR TPAGSVAGSV AGSVAGSVAG SATTATATRA RVDGTSGAGS DGGRLPTARI
     WMGLFPYLLV IAVFSVSKLV PPVKAFLAGT DQKIAWPGLD GHVLSAAGKP ISSTVYSFQW
     LSSPGTMLLL SGIVVAIAYR ISARQAVRDF TGTVVKLRWA ILTVASVLAL AYVMNFSGQT
     ISIGTWIAGT GAFFAFLSPV LGWIGTAVTG SDTSANALFA KLQATAGSHA GINESLLVSA
     NTTGGVVGKM ISPQNLTIAA SSAGLDGQES AILRRVLPWS LGLLLFLCVL VFLQSTPILG
     WMLP
//

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